@struexm.bsky.social
Our paper is out in PNAS: We decoded how NorA (S. aureus) exports diverse antibiotics.
We found energetic efficiency drives polyspecificity—efficient pumps can export many drugs, while inefficient ones are limited. Also: distal residues can still drive specificity.
www.pnas.org/doi/10.1073/...
We found energetic efficiency drives polyspecificity—efficient pumps can export many drugs, while inefficient ones are limited. Also: distal residues can still drive specificity.
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
January 5, 2026 at 4:56 PM
Our paper is out in PNAS: We decoded how NorA (S. aureus) exports diverse antibiotics.
We found energetic efficiency drives polyspecificity—efficient pumps can export many drugs, while inefficient ones are limited. Also: distal residues can still drive specificity.
www.pnas.org/doi/10.1073/...
We found energetic efficiency drives polyspecificity—efficient pumps can export many drugs, while inefficient ones are limited. Also: distal residues can still drive specificity.
www.pnas.org/doi/10.1073/...
The bulk of my thesis work is online!
We used deep mutational scanning to learn how NorA, a multidrug efflux pump from S. aureus, exports so many dissimilar drugs. The role of energy efficiency in this phenomenon is especially interesting and satisfying. Check it out:
www.biorxiv.org/content/10.1...
We used deep mutational scanning to learn how NorA, a multidrug efflux pump from S. aureus, exports so many dissimilar drugs. The role of energy efficiency in this phenomenon is especially interesting and satisfying. Check it out:
www.biorxiv.org/content/10.1...
www.biorxiv.org
April 11, 2025 at 7:49 PM
The bulk of my thesis work is online!
We used deep mutational scanning to learn how NorA, a multidrug efflux pump from S. aureus, exports so many dissimilar drugs. The role of energy efficiency in this phenomenon is especially interesting and satisfying. Check it out:
www.biorxiv.org/content/10.1...
We used deep mutational scanning to learn how NorA, a multidrug efflux pump from S. aureus, exports so many dissimilar drugs. The role of energy efficiency in this phenomenon is especially interesting and satisfying. Check it out:
www.biorxiv.org/content/10.1...
Reposted
Online now! #chembiol
Understanding, inhibiting, and engineering membrane transporters with high-throughput mutational screens
Promiscuous transporters play critical roles across human health and biotechnology. Here, Miller et al. discuss the need for high-throughput methods to address open questions in the field. They outline high-throughput screening for transporters, proposing potential screens and advocating broader adoption of these powerful techniques to understand, inhibit, and engineer transporters.
dlvr.it
March 31, 2025 at 3:31 PM
Online now! #chembiol