Adam Strandberg
@strandbergbio.bsky.social
Graduate student in the Needleman Lab at Harvard. Working on single-cell respirometry.
strandberg.bio
strandberg.bio
Reposted by Adam Strandberg
... cells within a given logarithmic size class contribute an equal fraction to the body’s total cellular biomass.
September 13, 2025 at 11:25 AM
... cells within a given logarithmic size class contribute an equal fraction to the body’s total cellular biomass.
Reposted by Adam Strandberg
I don’t! Likely it would look a lot like normal Luria-Delbruck since the relative rate of spacer acquisition is significantly lower than receptor modifications.
But Manoshi Datta and Roy Kishony have a great perspective piece on this from 2018:
www.nature.com/articles/d41...
But Manoshi Datta and Roy Kishony have a great perspective piece on this from 2018:
www.nature.com/articles/d41...
A spotlight on bacterial mutations for 75 years
Revisiting a 1943 paper that illuminated how bacterial mutations arise.
www.nature.com
January 13, 2025 at 12:52 PM
I don’t! Likely it would look a lot like normal Luria-Delbruck since the relative rate of spacer acquisition is significantly lower than receptor modifications.
But Manoshi Datta and Roy Kishony have a great perspective piece on this from 2018:
www.nature.com/articles/d41...
But Manoshi Datta and Roy Kishony have a great perspective piece on this from 2018:
www.nature.com/articles/d41...
If it is Poisson, then there's an interesting alternate history you can write! Of course, you would still see random mutations for antibiotic resistance (Lederberg, for instance), but one wonders how strongly that might have affected the trajectory of the Phage Group
January 12, 2025 at 10:06 PM
If it is Poisson, then there's an interesting alternate history you can write! Of course, you would still see random mutations for antibiotic resistance (Lederberg, for instance), but one wonders how strongly that might have affected the trajectory of the Phage Group
The strain they used (E. coli strain B) lacks CRISPR.
I don't know what you get when you do a fluctuation test on a strain with CRISPR- is it still a jackpot distribution, or is it mostly Poisson? I've been unable to find literature on this and haven't had an opportunity to try it yet
I don't know what you get when you do a fluctuation test on a strain with CRISPR- is it still a jackpot distribution, or is it mostly Poisson? I've been unable to find literature on this and haven't had an opportunity to try it yet
January 12, 2025 at 10:06 PM
The strain they used (E. coli strain B) lacks CRISPR.
I don't know what you get when you do a fluctuation test on a strain with CRISPR- is it still a jackpot distribution, or is it mostly Poisson? I've been unable to find literature on this and haven't had an opportunity to try it yet
I don't know what you get when you do a fluctuation test on a strain with CRISPR- is it still a jackpot distribution, or is it mostly Poisson? I've been unable to find literature on this and haven't had an opportunity to try it yet