Devon Stork
@storkdevon.bsky.social
Scientist, synthetic biology. Nonprofit cofounder. I edit microbial genomes and take lots of notes. Writer on the side.
The part on zero-shot predictions on proteins & RNAs was neat, but doesn't seem revolutionary. They can match other predictive algorithms for fitness of protein/RNA. There's a ceiling on what these models can currently do and they've run into it by using a lot more data. Sure?
November 22, 2024 at 12:01 AM
The part on zero-shot predictions on proteins & RNAs was neat, but doesn't seem revolutionary. They can match other predictive algorithms for fitness of protein/RNA. There's a ceiling on what these models can currently do and they've run into it by using a lot more data. Sure?
Figure 4E/S8 is exciting. Evo is good at predicting transposon boundaries with entropy, but I bet it encodes more data than that. Why is entropy high at the start of TnpA? What does it look like for bigger operons? Can we use this to explain biological functionality & essentiality at operon-scale?
November 22, 2024 at 12:01 AM
Figure 4E/S8 is exciting. Evo is good at predicting transposon boundaries with entropy, but I bet it encodes more data than that. Why is entropy high at the start of TnpA? What does it look like for bigger operons? Can we use this to explain biological functionality & essentiality at operon-scale?