Stijn Nuiten
@stijnnuiten.bsky.social
Postdoctoral researcher at the Translational Psychiatry Lab, University of Basel & UPK Basel.
Interested in the role of neuromodulatory systems and arousal on perception in health and disease.
Interested in the role of neuromodulatory systems and arousal on perception in health and disease.
For more details, go check out the full preprint at: dx.doi.org/10.21203/rs.... (6/6)
Phasic and tonic arousal distinctly shape human decision bias
Neuroscientific theories hypothesize that arousal fluctuations influence human perception and behavior in two functionally distinct ways: through variations in baseline state (tonic arousal) and by tr...
dx.doi.org
May 19, 2025 at 3:13 PM
For more details, go check out the full preprint at: dx.doi.org/10.21203/rs.... (6/6)
Neural and computational analyses further revealed that task effects on preparatory activity over motor cortex, resembling a starting point bias, were smallest on trials with high phasic pupil-linked arousal. (5/6)
May 19, 2025 at 3:13 PM
Neural and computational analyses further revealed that task effects on preparatory activity over motor cortex, resembling a starting point bias, were smallest on trials with high phasic pupil-linked arousal. (5/6)
Where increased tonic arousal (pupil-linked; trend for drugs) was related to more liberal ('yes') decisions independent of task, increased phasic arousal was uniquely associated with weaker task-related shifts in decision bias. Tonic & phasic arousal thus distinctly shaped decision bias. (4/6)
May 19, 2025 at 3:13 PM
Where increased tonic arousal (pupil-linked; trend for drugs) was related to more liberal ('yes') decisions independent of task, increased phasic arousal was uniquely associated with weaker task-related shifts in decision bias. Tonic & phasic arousal thus distinctly shaped decision bias. (4/6)
Here, we aimed to 1) uncover the neural mechanisms by which arousal governs decision bias and 2) causally test if/how tonic arousal affects bias. To do so, we combined correlational measures (pupillometry) & causal manipulations (pharmacology) of arousal with EEG and two bias-inducing tasks. (3/6)
May 19, 2025 at 3:13 PM
Here, we aimed to 1) uncover the neural mechanisms by which arousal governs decision bias and 2) causally test if/how tonic arousal affects bias. To do so, we combined correlational measures (pupillometry) & causal manipulations (pharmacology) of arousal with EEG and two bias-inducing tasks. (3/6)
Earlier work from our group revealed profound behavioral arousal effects: e.g. elevated tonic arousal improves centroparietal sensory evidence accumulation but impairs prefrontal metacognitive processes (doi.org/10.1523/ENEU...), while phasic arousal modulates bias (De Gee et al, eLife, 2017). (2/6)
Pharmacological Elevation of Catecholamine Levels Improves Perceptual Decisions, But Not Metacognitive Insight
Perceptual decisions are often accompanied by a feeling of decision confidence. Where the parietal cortex is known for its crucial role in shaping such perceptual decisions, metacognitive evaluations ...
doi.org
May 19, 2025 at 3:13 PM
Earlier work from our group revealed profound behavioral arousal effects: e.g. elevated tonic arousal improves centroparietal sensory evidence accumulation but impairs prefrontal metacognitive processes (doi.org/10.1523/ENEU...), while phasic arousal modulates bias (De Gee et al, eLife, 2017). (2/6)