Stephen Stone, MD 🔬🧬🐁✏️
@stevestonedraws.bsky.social
Peds Endo & Physician Scientist | Amateur Medical Illustrator | Live Sketchnotes | Dabbles in Python | Tweets are my own | Reposts != Endorsement | bmc.link/DiabetesNinja | stonelab.wustl.edu
Honored to recognize World Diabetes Day with The Stone Lab 💙. Grateful for our incredible team pushing research forward to better understand, treat, and prevent diabetes. Here’s to science that truly makes a difference.
#WorldDiabetesDay @washumedicine.bsky.social
#WorldDiabetesDay @washumedicine.bsky.social
November 15, 2025 at 1:54 AM
Honored to recognize World Diabetes Day with The Stone Lab 💙. Grateful for our incredible team pushing research forward to better understand, treat, and prevent diabetes. Here’s to science that truly makes a difference.
#WorldDiabetesDay @washumedicine.bsky.social
#WorldDiabetesDay @washumedicine.bsky.social
Amazing presentation by Dr. Andrew Janowski exploring astroviruses 🧬 — key players in gastroenteritis and encephalitis 🧠. Fascinating insights into the enigmatic S2M motif and its RNA “on/off” switch behavior! #PPI @washumedicine.bsky.social
November 12, 2025 at 12:46 AM
Amazing presentation by Dr. Andrew Janowski exploring astroviruses 🧬 — key players in gastroenteritis and encephalitis 🧠. Fascinating insights into the enigmatic S2M motif and its RNA “on/off” switch behavior! #PPI @washumedicine.bsky.social
Dr. Mary-Elizabeth Patti dives into the mystery of post-bariatric hypoglycemia — why only some patients are affected, and how bile acid–FGF19 pathways, serotonin, and enteroendocrine signaling may guide new treatments.
#BariatricSurgery #Metabolism #Endocrinology @washumedicine.bsky.social
#BariatricSurgery #Metabolism #Endocrinology @washumedicine.bsky.social
November 7, 2025 at 2:15 AM
Dr. Mary-Elizabeth Patti dives into the mystery of post-bariatric hypoglycemia — why only some patients are affected, and how bile acid–FGF19 pathways, serotonin, and enteroendocrine signaling may guide new treatments.
#BariatricSurgery #Metabolism #Endocrinology @washumedicine.bsky.social
#BariatricSurgery #Metabolism #Endocrinology @washumedicine.bsky.social
Dr. Bess Marshall’s Grand Rounds on GLP-1 physiology highlighted how gut-derived hormones talk to the brain to regulate insulin, appetite, and energy balance. 🧬
A perfect reminder that the gut is more than digestion—it’s an endocrine organ!
@washumedicine.bsky.social
A perfect reminder that the gut is more than digestion—it’s an endocrine organ!
@washumedicine.bsky.social
October 25, 2025 at 3:16 AM
Dr. Bess Marshall’s Grand Rounds on GLP-1 physiology highlighted how gut-derived hormones talk to the brain to regulate insulin, appetite, and energy balance. 🧬
A perfect reminder that the gut is more than digestion—it’s an endocrine organ!
@washumedicine.bsky.social
A perfect reminder that the gut is more than digestion—it’s an endocrine organ!
@washumedicine.bsky.social
Viruses and autoimmunity collide.
Dr. Tarin Bigley, MD PhD, reveals how HHV6 infection disrupts thymic development, increasing autoimmune risk—from murine models to thymus transplants in DiGeorge Syndrome.
#PPI @washumedicine.bsky.social
Dr. Tarin Bigley, MD PhD, reveals how HHV6 infection disrupts thymic development, increasing autoimmune risk—from murine models to thymus transplants in DiGeorge Syndrome.
#PPI @washumedicine.bsky.social
October 21, 2025 at 8:51 PM
Viruses and autoimmunity collide.
Dr. Tarin Bigley, MD PhD, reveals how HHV6 infection disrupts thymic development, increasing autoimmune risk—from murine models to thymus transplants in DiGeorge Syndrome.
#PPI @washumedicine.bsky.social
Dr. Tarin Bigley, MD PhD, reveals how HHV6 infection disrupts thymic development, increasing autoimmune risk—from murine models to thymus transplants in DiGeorge Syndrome.
#PPI @washumedicine.bsky.social
Exciting progress in Wolfram syndrome! Dr. Fumihiko Urano outlines new therapies — from AMX0114 drug trials to gene-editing strategies aimed at restoring β-cell function and neuroprotection. Collaboration with patient groups is key.
#WolframSyndrome #RareDisease @washumedicine.bsky.social
#WolframSyndrome #RareDisease @washumedicine.bsky.social
October 17, 2025 at 12:34 AM
Exciting progress in Wolfram syndrome! Dr. Fumihiko Urano outlines new therapies — from AMX0114 drug trials to gene-editing strategies aimed at restoring β-cell function and neuroprotection. Collaboration with patient groups is key.
#WolframSyndrome #RareDisease @washumedicine.bsky.social
#WolframSyndrome #RareDisease @washumedicine.bsky.social
Maternal diet shapes the next generation. Dr. Mike Thompson shared how obesogenic diets in mothers profoundly alter the gut microbiome and bile acid metabolism of offspring.
#PPI @washumedicine.bsky.social
@hepatocrinologist.bsky.social
#PPI @washumedicine.bsky.social
@hepatocrinologist.bsky.social
October 11, 2025 at 1:46 AM
Maternal diet shapes the next generation. Dr. Mike Thompson shared how obesogenic diets in mothers profoundly alter the gut microbiome and bile acid metabolism of offspring.
#PPI @washumedicine.bsky.social
@hepatocrinologist.bsky.social
#PPI @washumedicine.bsky.social
@hepatocrinologist.bsky.social
Dr. Colin G. Nichols shared how the KATP channel drives both neonatal diabetes & congenital hyperinsulinism. 🧬 Key insights: SUR1 mutations, shifts in calcium sensitivity, & why diazoxide works (when sulfonylureas may not).
@washumedicine.bsky.social @colinnicholslab.bsky.social #EndoSky
@washumedicine.bsky.social @colinnicholslab.bsky.social #EndoSky
September 19, 2025 at 1:47 AM
Dr. Colin G. Nichols shared how the KATP channel drives both neonatal diabetes & congenital hyperinsulinism. 🧬 Key insights: SUR1 mutations, shifts in calcium sensitivity, & why diazoxide works (when sulfonylureas may not).
@washumedicine.bsky.social @colinnicholslab.bsky.social #EndoSky
@washumedicine.bsky.social @colinnicholslab.bsky.social #EndoSky
Euglycemic DKA can develop in patients on SGLT2 inhibitors — even without diabetes. ⚠️ Important to counsel families on fasting and DKA symptoms as use of these meds grows in pediatric heart failure. @washumedicine.bsky.social
#Endocrinology #DiabetesCare #HeartFailure #MedTwitter
#Endocrinology #DiabetesCare #HeartFailure #MedTwitter
September 19, 2025 at 1:38 AM
Euglycemic DKA can develop in patients on SGLT2 inhibitors — even without diabetes. ⚠️ Important to counsel families on fasting and DKA symptoms as use of these meds grows in pediatric heart failure. @washumedicine.bsky.social
#Endocrinology #DiabetesCare #HeartFailure #MedTwitter
#Endocrinology #DiabetesCare #HeartFailure #MedTwitter
Sketchnote from Dr. Carmen Halabi’s talk:
👉 Lox is essential for elastin in large vessels
👉 Knockout = aortic aneurysms
👉 Early mortality in mice
👉 Why is the ascending aorta most at risk?
Big insights at the interface of genetics + vascular biology!
#Research @washumedicine.bsky.social
👉 Lox is essential for elastin in large vessels
👉 Knockout = aortic aneurysms
👉 Early mortality in mice
👉 Why is the ascending aorta most at risk?
Big insights at the interface of genetics + vascular biology!
#Research @washumedicine.bsky.social
September 17, 2025 at 1:17 AM
Sketchnote from Dr. Carmen Halabi’s talk:
👉 Lox is essential for elastin in large vessels
👉 Knockout = aortic aneurysms
👉 Early mortality in mice
👉 Why is the ascending aorta most at risk?
Big insights at the interface of genetics + vascular biology!
#Research @washumedicine.bsky.social
👉 Lox is essential for elastin in large vessels
👉 Knockout = aortic aneurysms
👉 Early mortality in mice
👉 Why is the ascending aorta most at risk?
Big insights at the interface of genetics + vascular biology!
#Research @washumedicine.bsky.social
🌟 Grand Rounds with Dr. Megan Cooper 🌟
One patient’s story can unlock diagnoses for dozens more. 🧬
From inborn errors of immunity to targeted therapies, genome sequencing is transforming care for #PrimaryImmuneDeficiency.
#Genomics #PrecisionMedicine #Pediatrics #RareDisease
One patient’s story can unlock diagnoses for dozens more. 🧬
From inborn errors of immunity to targeted therapies, genome sequencing is transforming care for #PrimaryImmuneDeficiency.
#Genomics #PrecisionMedicine #Pediatrics #RareDisease
August 8, 2025 at 7:44 PM
🌟 Grand Rounds with Dr. Megan Cooper 🌟
One patient’s story can unlock diagnoses for dozens more. 🧬
From inborn errors of immunity to targeted therapies, genome sequencing is transforming care for #PrimaryImmuneDeficiency.
#Genomics #PrecisionMedicine #Pediatrics #RareDisease
One patient’s story can unlock diagnoses for dozens more. 🧬
From inborn errors of immunity to targeted therapies, genome sequencing is transforming care for #PrimaryImmuneDeficiency.
#Genomics #PrecisionMedicine #Pediatrics #RareDisease
That’s a wrap on #ENDO2025!
Thank you to the incredible speakers, attendees, and organizers who made this week unforgettable.
Sketching my way through the science was a blast—what was your favorite?
@endocrinesociety.bsky.social
Thank you to the incredible speakers, attendees, and organizers who made this week unforgettable.
Sketching my way through the science was a blast—what was your favorite?
@endocrinesociety.bsky.social
July 16, 2025 at 3:56 AM
That’s a wrap on #ENDO2025!
Thank you to the incredible speakers, attendees, and organizers who made this week unforgettable.
Sketching my way through the science was a blast—what was your favorite?
@endocrinesociety.bsky.social
Thank you to the incredible speakers, attendees, and organizers who made this week unforgettable.
Sketching my way through the science was a blast—what was your favorite?
@endocrinesociety.bsky.social
Christoffer Clemmensen’s #ENDO2025 talk forecasted what’s coming next in obesity pharmacotherapy:
💉 Dual/triple/quad agonists (GLP-1, GIP, amylin, glucagon)
🧠 NMDA receptor targets = neuroplasticity
🔬 ghrelin → prevents regain
📉 GLP-1/GIP/meranzin combo↓
@endocrinesociety.bsky.social
💉 Dual/triple/quad agonists (GLP-1, GIP, amylin, glucagon)
🧠 NMDA receptor targets = neuroplasticity
🔬 ghrelin → prevents regain
📉 GLP-1/GIP/meranzin combo↓
@endocrinesociety.bsky.social
July 15, 2025 at 5:31 PM
Christoffer Clemmensen’s #ENDO2025 talk forecasted what’s coming next in obesity pharmacotherapy:
💉 Dual/triple/quad agonists (GLP-1, GIP, amylin, glucagon)
🧠 NMDA receptor targets = neuroplasticity
🔬 ghrelin → prevents regain
📉 GLP-1/GIP/meranzin combo↓
@endocrinesociety.bsky.social
💉 Dual/triple/quad agonists (GLP-1, GIP, amylin, glucagon)
🧠 NMDA receptor targets = neuroplasticity
🔬 ghrelin → prevents regain
📉 GLP-1/GIP/meranzin combo↓
@endocrinesociety.bsky.social
Robert Semple at #ENDO2025 is pushing boundaries with deep mutational scanning of the #insulin receptor:
🔬 Testing all possible variants
🧩 Critical insights into cysteine-rich domains
🧠 Epitope mapping + therapeutic responsiveness
@endocrinesociety.bsky.social
🔬 Testing all possible variants
🧩 Critical insights into cysteine-rich domains
🧠 Epitope mapping + therapeutic responsiveness
@endocrinesociety.bsky.social
July 15, 2025 at 6:55 AM
Robert Semple at #ENDO2025 is pushing boundaries with deep mutational scanning of the #insulin receptor:
🔬 Testing all possible variants
🧩 Critical insights into cysteine-rich domains
🧠 Epitope mapping + therapeutic responsiveness
@endocrinesociety.bsky.social
🔬 Testing all possible variants
🧩 Critical insights into cysteine-rich domains
🧠 Epitope mapping + therapeutic responsiveness
@endocrinesociety.bsky.social
Vincent Harley at #ENDO2025 identified 2 novel genes in 46,XY DSD:
🧠 MAP3K7 kinase domain variants—Sertoli-specific, WNT-β-catenin disruption
🧬 DMRT3 variants—potential estrogen activation & gain-of-function
@endocrinesociety.bsky.social
#DSD #Genetics
🧠 MAP3K7 kinase domain variants—Sertoli-specific, WNT-β-catenin disruption
🧬 DMRT3 variants—potential estrogen activation & gain-of-function
@endocrinesociety.bsky.social
#DSD #Genetics
July 15, 2025 at 6:50 AM
Vincent Harley at #ENDO2025 identified 2 novel genes in 46,XY DSD:
🧠 MAP3K7 kinase domain variants—Sertoli-specific, WNT-β-catenin disruption
🧬 DMRT3 variants—potential estrogen activation & gain-of-function
@endocrinesociety.bsky.social
#DSD #Genetics
🧠 MAP3K7 kinase domain variants—Sertoli-specific, WNT-β-catenin disruption
🧬 DMRT3 variants—potential estrogen activation & gain-of-function
@endocrinesociety.bsky.social
#DSD #Genetics
Luca Persani on behalf of Federica Marelli presented cutting-edge models of thyroid hormone resistance at #ENDO2025:
🐟 Zebrafish = functional platform for VUS
📉 Easier to ID THRβ defects via TFT signature
📘 Guidelines -specific variant interpretation
@endocrinesociety.bsky.social
#ThyroidGenetics
🐟 Zebrafish = functional platform for VUS
📉 Easier to ID THRβ defects via TFT signature
📘 Guidelines -specific variant interpretation
@endocrinesociety.bsky.social
#ThyroidGenetics
July 15, 2025 at 6:36 AM
Luca Persani on behalf of Federica Marelli presented cutting-edge models of thyroid hormone resistance at #ENDO2025:
🐟 Zebrafish = functional platform for VUS
📉 Easier to ID THRβ defects via TFT signature
📘 Guidelines -specific variant interpretation
@endocrinesociety.bsky.social
#ThyroidGenetics
🐟 Zebrafish = functional platform for VUS
📉 Easier to ID THRβ defects via TFT signature
📘 Guidelines -specific variant interpretation
@endocrinesociety.bsky.social
#ThyroidGenetics
Tracy Rankin’s #ENDO2025 session was full of practical grant-writing advice:
✅ Know when to contact your program vs. review officer
✅ Tailor your career dev plan for Ks
✅ Plan for conceptual + technical pitfalls
✅ Be aware of timelines—and stay resilient!
@endocrinesociety.bsky.social #NIDDK
✅ Know when to contact your program vs. review officer
✅ Tailor your career dev plan for Ks
✅ Plan for conceptual + technical pitfalls
✅ Be aware of timelines—and stay resilient!
@endocrinesociety.bsky.social #NIDDK
July 15, 2025 at 6:20 AM
Tracy Rankin’s #ENDO2025 session was full of practical grant-writing advice:
✅ Know when to contact your program vs. review officer
✅ Tailor your career dev plan for Ks
✅ Plan for conceptual + technical pitfalls
✅ Be aware of timelines—and stay resilient!
@endocrinesociety.bsky.social #NIDDK
✅ Know when to contact your program vs. review officer
✅ Tailor your career dev plan for Ks
✅ Plan for conceptual + technical pitfalls
✅ Be aware of timelines—and stay resilient!
@endocrinesociety.bsky.social #NIDDK
Jens Holst at #ENDO2025 called incretins “the silver bullet”—and for good reason:
💡 Modified GLP-1 has powerful central effects
🫀 Broad benefits: ↓ CV risk, ↓ inflammation, sleep apnea, MASH, Cancer?
🔑 Lifestyle change is key to keeping the weight off.
@endocrinesociety.bsky.social
💡 Modified GLP-1 has powerful central effects
🫀 Broad benefits: ↓ CV risk, ↓ inflammation, sleep apnea, MASH, Cancer?
🔑 Lifestyle change is key to keeping the weight off.
@endocrinesociety.bsky.social
July 15, 2025 at 6:13 AM
Jens Holst at #ENDO2025 called incretins “the silver bullet”—and for good reason:
💡 Modified GLP-1 has powerful central effects
🫀 Broad benefits: ↓ CV risk, ↓ inflammation, sleep apnea, MASH, Cancer?
🔑 Lifestyle change is key to keeping the weight off.
@endocrinesociety.bsky.social
💡 Modified GLP-1 has powerful central effects
🫀 Broad benefits: ↓ CV risk, ↓ inflammation, sleep apnea, MASH, Cancer?
🔑 Lifestyle change is key to keeping the weight off.
@endocrinesociety.bsky.social
🚨 Poster alert! I’ll be presenting MON-573 at #ENDO2025 today from 12–1:30 PM.
🧬 Come learn about novel GLUT4 (SLC2A4) variants in atypical young-onset diabetes
📊 Proud to be part of the #RADIANT -study and this incredible research community.
@endocrinesociety.bsky.social
🧬 Come learn about novel GLUT4 (SLC2A4) variants in atypical young-onset diabetes
📊 Proud to be part of the #RADIANT -study and this incredible research community.
@endocrinesociety.bsky.social
July 14, 2025 at 3:52 PM
🚨 Poster alert! I’ll be presenting MON-573 at #ENDO2025 today from 12–1:30 PM.
🧬 Come learn about novel GLUT4 (SLC2A4) variants in atypical young-onset diabetes
📊 Proud to be part of the #RADIANT -study and this incredible research community.
@endocrinesociety.bsky.social
🧬 Come learn about novel GLUT4 (SLC2A4) variants in atypical young-onset diabetes
📊 Proud to be part of the #RADIANT -study and this incredible research community.
@endocrinesociety.bsky.social
At #ENDO2025, dinner with some of the most brilliant and kind-hearted Peds Endos I’ve ever met.
These are the moments that make conferences meaningful—connection, mentorship, and shared purpose.
@endocrinesociety.bsky.social #PedsEndo
These are the moments that make conferences meaningful—connection, mentorship, and shared purpose.
@endocrinesociety.bsky.social #PedsEndo
July 14, 2025 at 5:27 AM
At #ENDO2025, dinner with some of the most brilliant and kind-hearted Peds Endos I’ve ever met.
These are the moments that make conferences meaningful—connection, mentorship, and shared purpose.
@endocrinesociety.bsky.social #PedsEndo
These are the moments that make conferences meaningful—connection, mentorship, and shared purpose.
@endocrinesociety.bsky.social #PedsEndo
#ENDO2025 “Meet the Professors” session featured Onno Holleboom & Eveline Bruinstroop with updates on MASLD:
🧬 FGF21 analogs + PPARδ = emerging therapies
📊 FIT-4 score + FibroScan = easy, non-invasive tools
🧠 GLP-1s may help too
@endocrinesociety.bsky.social
#MASLD
🧬 FGF21 analogs + PPARδ = emerging therapies
📊 FIT-4 score + FibroScan = easy, non-invasive tools
🧠 GLP-1s may help too
@endocrinesociety.bsky.social
#MASLD
July 14, 2025 at 5:19 AM
#ENDO2025 “Meet the Professors” session featured Onno Holleboom & Eveline Bruinstroop with updates on MASLD:
🧬 FGF21 analogs + PPARδ = emerging therapies
📊 FIT-4 score + FibroScan = easy, non-invasive tools
🧠 GLP-1s may help too
@endocrinesociety.bsky.social
#MASLD
🧬 FGF21 analogs + PPARδ = emerging therapies
📊 FIT-4 score + FibroScan = easy, non-invasive tools
🧠 GLP-1s may help too
@endocrinesociety.bsky.social
#MASLD
At #ENDO2025, Iza Machado shared key data linking puberty timing to adult cardiometabolic health:
📍 Early menarche = ↑ CV risk
📍 Late menarche = ↑ coronary artery disease
📊 Based on a large population cohort from Brazil
@endocrinesociety.bsky.social
#PubertyMatters #ENDO2025
📍 Early menarche = ↑ CV risk
📍 Late menarche = ↑ coronary artery disease
📊 Based on a large population cohort from Brazil
@endocrinesociety.bsky.social
#PubertyMatters #ENDO2025
July 14, 2025 at 5:13 AM
At #ENDO2025, Iza Machado shared key data linking puberty timing to adult cardiometabolic health:
📍 Early menarche = ↑ CV risk
📍 Late menarche = ↑ coronary artery disease
📊 Based on a large population cohort from Brazil
@endocrinesociety.bsky.social
#PubertyMatters #ENDO2025
📍 Early menarche = ↑ CV risk
📍 Late menarche = ↑ coronary artery disease
📊 Based on a large population cohort from Brazil
@endocrinesociety.bsky.social
#PubertyMatters #ENDO2025
Found my dose on the wall!
137 mcg Synthroid, powering me since 1994.
Here’s to #ENDO2025, long-term hormone therapy, and stable thyroid vibes 🦋#LevothyroxineLife @endocrinesociety.bsky.social @abbvie.bsky.social
137 mcg Synthroid, powering me since 1994.
Here’s to #ENDO2025, long-term hormone therapy, and stable thyroid vibes 🦋#LevothyroxineLife @endocrinesociety.bsky.social @abbvie.bsky.social
July 13, 2025 at 5:09 AM
Found my dose on the wall!
137 mcg Synthroid, powering me since 1994.
Here’s to #ENDO2025, long-term hormone therapy, and stable thyroid vibes 🦋#LevothyroxineLife @endocrinesociety.bsky.social @abbvie.bsky.social
137 mcg Synthroid, powering me since 1994.
Here’s to #ENDO2025, long-term hormone therapy, and stable thyroid vibes 🦋#LevothyroxineLife @endocrinesociety.bsky.social @abbvie.bsky.social
At #ENDO2025, Melanie Haines emphasized the need to monitor muscle and bone health in patients on GLP-1 therapy:
🏋️♀️ Muscle loss is an under-recognized concern
👵 Women + older adults face higher risk
🦴 Bone resorption via CTX?
Whole-patient care matters.
@endocrinesociety.bsky.social
🏋️♀️ Muscle loss is an under-recognized concern
👵 Women + older adults face higher risk
🦴 Bone resorption via CTX?
Whole-patient care matters.
@endocrinesociety.bsky.social
July 13, 2025 at 3:21 AM
At #ENDO2025, Melanie Haines emphasized the need to monitor muscle and bone health in patients on GLP-1 therapy:
🏋️♀️ Muscle loss is an under-recognized concern
👵 Women + older adults face higher risk
🦴 Bone resorption via CTX?
Whole-patient care matters.
@endocrinesociety.bsky.social
🏋️♀️ Muscle loss is an under-recognized concern
👵 Women + older adults face higher risk
🦴 Bone resorption via CTX?
Whole-patient care matters.
@endocrinesociety.bsky.social
Rossella Cannarella at #ENDO2025 highlighted how tirzepatide might address more than just weight:
🧬 Effective for metabolic hypogonadism
🍆 Boosts sexual function
👶 May hold promise for fertility
🔍 Could Sertoli-sperm cell signaling be key?
Big questions, big potential.
@endocrinesociety.bsky.social
🧬 Effective for metabolic hypogonadism
🍆 Boosts sexual function
👶 May hold promise for fertility
🔍 Could Sertoli-sperm cell signaling be key?
Big questions, big potential.
@endocrinesociety.bsky.social
July 13, 2025 at 3:15 AM
Rossella Cannarella at #ENDO2025 highlighted how tirzepatide might address more than just weight:
🧬 Effective for metabolic hypogonadism
🍆 Boosts sexual function
👶 May hold promise for fertility
🔍 Could Sertoli-sperm cell signaling be key?
Big questions, big potential.
@endocrinesociety.bsky.social
🧬 Effective for metabolic hypogonadism
🍆 Boosts sexual function
👶 May hold promise for fertility
🔍 Could Sertoli-sperm cell signaling be key?
Big questions, big potential.
@endocrinesociety.bsky.social