Steven Artandi
@stevenartandi.bsky.social
Cancer scientist and oncologist, Professor at Stanford and Director of the Stanford Cancer Institute
SCI member Lawrence Recht & others found that in IDH-mutant gliomas, adjuvant radiation (aXRT) given within 3 months of diagnosis did not improve survival compared to deferred radiation (dXRT). pubmed.ncbi.nlm.nih.gov/40513058/
August 25, 2025 at 4:05 PM
SCI member Lawrence Recht & others found that in IDH-mutant gliomas, adjuvant radiation (aXRT) given within 3 months of diagnosis did not improve survival compared to deferred radiation (dXRT). pubmed.ncbi.nlm.nih.gov/40513058/
SCI member @lindakachuri.bsky.social and colleagues show that adding #polygenic risk scores to multimodal classifiers improves molecular subtyping before surgery. The approach enhanced prediction of isocitrate dehydrogenase mutation status in #glioma patients. www.nature.com/articles/s41...
August 22, 2025 at 4:04 PM
SCI member @lindakachuri.bsky.social and colleagues show that adding #polygenic risk scores to multimodal classifiers improves molecular subtyping before surgery. The approach enhanced prediction of isocitrate dehydrogenase mutation status in #glioma patients. www.nature.com/articles/s41...
SCI member Erinn Rankin & others show FTO, an RNA demethylase, drives glutamine reprogramming in #ccRCC, promoting growth. Inhibiting FTO disrupts metabolism, > DNA damage, and reduces survival, but pyrimidines/antioxidants rescue, highlighting FTO as a target. pubmed.ncbi.nlm.nih.gov/40532011/
August 18, 2025 at 4:10 PM
SCI member Erinn Rankin & others show FTO, an RNA demethylase, drives glutamine reprogramming in #ccRCC, promoting growth. Inhibiting FTO disrupts metabolism, > DNA damage, and reduces survival, but pyrimidines/antioxidants rescue, highlighting FTO as a target. pubmed.ncbi.nlm.nih.gov/40532011/
SCI member Robert West & others found #DCIS comprises multiple genetic clones with significant phenotypic diversity and linked alterations in epithelial cell states and basement membrane integrity with invasive breast cancer progression.
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
August 15, 2025 at 4:11 PM
SCI member Robert West & others found #DCIS comprises multiple genetic clones with significant phenotypic diversity and linked alterations in epithelial cell states and basement membrane integrity with invasive breast cancer progression.
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
SCI members and others found radiotherapy increases immunosuppressive VISTA+ myeloid cells in head and neck cancer's microenvironment. VISTA blockade boosts #radiotherapy efficacy by promoting antitumor myeloid activity and T cell responses in multiple cancer models.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
August 13, 2025 at 4:07 PM
SCI members and others found radiotherapy increases immunosuppressive VISTA+ myeloid cells in head and neck cancer's microenvironment. VISTA blockade boosts #radiotherapy efficacy by promoting antitumor myeloid activity and T cell responses in multiple cancer models.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
SCI members found GPT-RadPlan, an AI-driven treatment planning framework, outperformed or matched human experts in prostate and head & neck cancer plans, improving target coverage and reducing organ-at-risk doses by 5 Gy, all with no extra training required. iopscience.iop.org/article/10.1...
August 11, 2025 at 4:04 PM
SCI members found GPT-RadPlan, an AI-driven treatment planning framework, outperformed or matched human experts in prostate and head & neck cancer plans, improving target coverage and reducing organ-at-risk doses by 5 Gy, all with no extra training required. iopscience.iop.org/article/10.1...
Gao lab created an ML-guided workflow to deimmunize human protein domains for safer #GeneTherapy. They built zinc fingers and drug-controllable transcription factors to target genes like UTRN and SCN1A. www.sciencedirect.com/science/arti... @synbiogaolab.bsky.social #AIandCancer
August 8, 2025 at 4:05 PM
Gao lab created an ML-guided workflow to deimmunize human protein domains for safer #GeneTherapy. They built zinc fingers and drug-controllable transcription factors to target genes like UTRN and SCN1A. www.sciencedirect.com/science/arti... @synbiogaolab.bsky.social #AIandCancer
SCI member Haruka Itakura and others developed an MRI-based model to predict survival risk in #TNBC patients, identifying high-risk groups with a 25% 5-year survival gap using a 50-gene signature. The tool showed strong accuracy and clinical potential. www.nature.com/articles/s41...
July 31, 2025 at 5:05 PM
SCI member Haruka Itakura and others developed an MRI-based model to predict survival risk in #TNBC patients, identifying high-risk groups with a 25% 5-year survival gap using a 50-gene signature. The tool showed strong accuracy and clinical potential. www.nature.com/articles/s41...
SCI member Edgar Engleman & team found tumors use erythropoietin (EPO) to block immune attack. In #LiverCancer models, tumor EPO reprograms macrophages via EPOR to create a T cell-poor environment. Blocking the EPO/EPOR axis reactivates immunity & shrinks tumors. pubmed.ncbi.nlm.nih.gov/40273234/
July 28, 2025 at 4:07 PM
SCI member Edgar Engleman & team found tumors use erythropoietin (EPO) to block immune attack. In #LiverCancer models, tumor EPO reprograms macrophages via EPOR to create a T cell-poor environment. Blocking the EPO/EPOR axis reactivates immunity & shrinks tumors. pubmed.ncbi.nlm.nih.gov/40273234/
SCI member Allison Kurian & others found that nearly half of #BreastCancer patients continue endocrine therapy beyond 5 years. The study emphasizes the importance of shared decision-making. academic.oup.com/jnci/advance...
July 25, 2025 at 4:04 PM
SCI member Allison Kurian & others found that nearly half of #BreastCancer patients continue endocrine therapy beyond 5 years. The study emphasizes the importance of shared decision-making. academic.oup.com/jnci/advance...
Alexa Pohl & others found that transportation insecurity negatively impacted #BreastaCancerScreening, while social support positively affected colorectal and #BreastCancer screening. No interaction was found between social support and transportation insecurity. jamanetwork.com/journals/jam...
July 23, 2025 at 4:06 PM
Alexa Pohl & others found that transportation insecurity negatively impacted #BreastaCancerScreening, while social support positively affected colorectal and #BreastCancer screening. No interaction was found between social support and transportation insecurity. jamanetwork.com/journals/jam...
Stanford postdoc Minji Jung & SCI members found #KidneyCancer survivors had a higher rate of depression and anxiety, especially during the early phase following diagnosis, compared with the noncancer population. aacrjournals.org/cebp/article...
July 21, 2025 at 4:12 PM
Stanford postdoc Minji Jung & SCI members found #KidneyCancer survivors had a higher rate of depression and anxiety, especially during the early phase following diagnosis, compared with the noncancer population. aacrjournals.org/cebp/article...
Post doc @jkim-1003.bsky.social & others found #AI natural language processing–enabled analysis of patient messages can generate valuable research topics that prioritize patient perspectives in #CancerCare, guiding future patient-centered health research. jamanetwork.com/journals/jam...
July 14, 2025 at 4:12 PM
Post doc @jkim-1003.bsky.social & others found #AI natural language processing–enabled analysis of patient messages can generate valuable research topics that prioritize patient perspectives in #CancerCare, guiding future patient-centered health research. jamanetwork.com/journals/jam...
SCI member Sydney Lu & others found mutations in RNA splicing factors drive mis-spliced mRNA isoforms in cancers. They identified neoantigens from splicing alterations in #leukemia, showing TCR-engineered T cells target these mutations. pubmed.ncbi.nlm.nih.gov/40273911/
July 11, 2025 at 4:06 PM
SCI member Sydney Lu & others found mutations in RNA splicing factors drive mis-spliced mRNA isoforms in cancers. They identified neoantigens from splicing alterations in #leukemia, showing TCR-engineered T cells target these mutations. pubmed.ncbi.nlm.nih.gov/40273911/
SCI member @johnleppert.bsky.social & others review the challenge of managing small renal masses, urging caution over reflexive treatment. Drawing lessons from low-risk #ProstateCancer, they propose the TOP model to reduce overtreatment. pubmed.ncbi.nlm.nih.gov/40447472/
July 9, 2025 at 4:08 PM
SCI member @johnleppert.bsky.social & others review the challenge of managing small renal masses, urging caution over reflexive treatment. Drawing lessons from low-risk #ProstateCancer, they propose the TOP model to reduce overtreatment. pubmed.ncbi.nlm.nih.gov/40447472/
SCI member Paul Mischel & others found that #ecDNA drives evolution & heterogeneity in urothelial carcinoma, playing an early role in tumorigenesis. The study highlights immune evasion mechanisms linked to ecDNA, offering insights for developing targeted therapies. pubmed.ncbi.nlm.nih.gov/40331621/
July 7, 2025 at 4:06 PM
SCI member Paul Mischel & others found that #ecDNA drives evolution & heterogeneity in urothelial carcinoma, playing an early role in tumorigenesis. The study highlights immune evasion mechanisms linked to ecDNA, offering insights for developing targeted therapies. pubmed.ncbi.nlm.nih.gov/40331621/
SCI member Seung Kim & others found that stromal KITL in the pancreas restrains tumor progression. Downregulation of KITL during tumorigenesis promotes cancer. KITL signaling may offer potential for cancer prevention without disrupting tissue homeostasis. pubmed.ncbi.nlm.nih.gov/39918337/
June 30, 2025 at 4:10 PM
SCI member Seung Kim & others found that stromal KITL in the pancreas restrains tumor progression. Downregulation of KITL during tumorigenesis promotes cancer. KITL signaling may offer potential for cancer prevention without disrupting tissue homeostasis. pubmed.ncbi.nlm.nih.gov/39918337/
SCI member Joel Neal & others found mobocertinib is not superior to platinum-based chemotherapy in treating EGFR ex20ins+ advanced/metastatic #NSCLC. No significant difference in progression-free survival, but mobocertinib showed longer response duration. pubmed.ncbi.nlm.nih.gov/39879577/
June 27, 2025 at 4:07 PM
SCI member Joel Neal & others found mobocertinib is not superior to platinum-based chemotherapy in treating EGFR ex20ins+ advanced/metastatic #NSCLC. No significant difference in progression-free survival, but mobocertinib showed longer response duration. pubmed.ncbi.nlm.nih.gov/39879577/
SCI member David Miklos & others report that allogeneic CD19 # CAR-T cells show 58% overall response and 42% complete response in CD19 CAR T-naïve patients with relapsed/refractory LBCL, with a manageable safety profile. pubmed.ncbi.nlm.nih.gov/39946666/ #LBCL"
June 25, 2025 at 4:11 PM
SCI member David Miklos & others report that allogeneic CD19 # CAR-T cells show 58% overall response and 42% complete response in CD19 CAR T-naïve patients with relapsed/refractory LBCL, with a manageable safety profile. pubmed.ncbi.nlm.nih.gov/39946666/ #LBCL"
Zhengyi Deng & others found excess weight and adult weight gain were associated with increased risk of #RenalCellCarcinoma (RCC), particularly ccRCC, whereas weight loss was associated with reduced risk. acsjournals.onlinelibrary.wiley.com/doi/abs/10.1...
June 23, 2025 at 4:08 PM
Zhengyi Deng & others found excess weight and adult weight gain were associated with increased risk of #RenalCellCarcinoma (RCC), particularly ccRCC, whereas weight loss was associated with reduced risk. acsjournals.onlinelibrary.wiley.com/doi/abs/10.1...
SCI members Michael Longaker, Tushar Desai, Howard Chang, & others establish an atlas of pro- and anti-fibrotic factors that underlie lung matrix architecture and implicate fibroblast-associated biological features in modulating #fibrotic progression vs resolution. www.nature.com/articles/s41...
June 20, 2025 at 4:05 PM
SCI members Michael Longaker, Tushar Desai, Howard Chang, & others establish an atlas of pro- and anti-fibrotic factors that underlie lung matrix architecture and implicate fibroblast-associated biological features in modulating #fibrotic progression vs resolution. www.nature.com/articles/s41...
SCI member Irv Weissman & team introduce an engineered #macrophage approach for cancer therapy. Using eSPR tech, macrophages target tumor heterogeneity, resist polarization, & enhance CD8 T-cell responses. Suggests potential for improved #CancerImmunotherapy. pubmed.ncbi.nlm.nih.gov/40307254/
June 18, 2025 at 4:08 PM
SCI member Irv Weissman & team introduce an engineered #macrophage approach for cancer therapy. Using eSPR tech, macrophages target tumor heterogeneity, resist polarization, & enhance CD8 T-cell responses. Suggests potential for improved #CancerImmunotherapy. pubmed.ncbi.nlm.nih.gov/40307254/
Stanford's Emma Lundberg & others create a global map of human subcellular architecture, revealing 275 molecular assemblies & unexpected roles for 975 proteins. Key discoveries include novel cancer proteins & insights into RNA processing & immune signaling. www.nature.com/articles/s41...
June 13, 2025 at 4:07 PM
Stanford's Emma Lundberg & others create a global map of human subcellular architecture, revealing 275 molecular assemblies & unexpected roles for 975 proteins. Key discoveries include novel cancer proteins & insights into RNA processing & immune signaling. www.nature.com/articles/s41...
SCI members Kara Davis & others reveal that low IKAROS levels in B-ALL cells predict antigen escape after #CAR_T therapy. IKAROS^low cells lose B-cell identity, reducing CD19/CD22 expression and increasing therapy resistance. IKAROS may be key to preventing relapse. www.nature.com/articles/s41...
June 6, 2025 at 4:07 PM
SCI members Kara Davis & others reveal that low IKAROS levels in B-ALL cells predict antigen escape after #CAR_T therapy. IKAROS^low cells lose B-cell identity, reducing CD19/CD22 expression and increasing therapy resistance. IKAROS may be key to preventing relapse. www.nature.com/articles/s41...
SCI member @everettmoding.bsky.social & others demonstrate that radiation therapy exerts selective pressures on undifferentiated pleomorphic sarcomas and suggest that targeting radioresistant subclonal populations could improve outcomes after radiotherapy. aacrjournals.org/cancerres/ar...
May 23, 2025 at 4:05 PM
SCI member @everettmoding.bsky.social & others demonstrate that radiation therapy exerts selective pressures on undifferentiated pleomorphic sarcomas and suggest that targeting radioresistant subclonal populations could improve outcomes after radiotherapy. aacrjournals.org/cancerres/ar...