RIP Alex's catalytic converter

The dG thing is new and weird to me. But could a chemist analogy here be saying that breaking strained bonds (in cyclobutane or pick your favorite exemplar) "releases strain energy?" There is a problem in the formalism and the lure of "the line goes away" is too strong

Similar to some other suggestions, but Dowtherm A should work and you can find a few refs for its use in hi temp reactions

This really has the same feel as Niepce's window

You could do amine + CDI then benzyl alcohol (or alcohol first) if you are in a pinch. Shows up a fair amount for substituted benzyl variants

Here are some of mine after just one year. So much paler! But kind of ethereal

It's these failures to do basic governance that make me extremely worried that we are not going to weather and recover from this administration

5!

Your axis should be Millions not Billions (implies spending is $117 trillion). It would also be helpful if the years were indicated with the months

Who wants API salt extraction? 🙋‍♂️ Who wants to live next to API salt extraction? 🙅‍♂️

I find these papers somewhat interesting but mostly baffling (on top of the questionable description of synthesis). Are these numbers high? Compared to what? Should we aim to have a 100-mile pharmacopoeia?

Are you asking about the use of prophetic?

Alternatively, another personal fav, have you looked at TBD-mediated ester functionalization? e.g. doi.org/10.1021/op30...

A nice little reaction idea, I've used it on polycarboxylic acids. It can benefit from the standard cat. DMF as well

I would kindly suggest a Sankey - designed to show flows - is not the appropriate way to represent this data.