Leif Østergaard
@stergaard-leif.bsky.social
Neuroscientist interested in brain energy metabolism in brain health and disease.
Professor and director, CFIN, Dept. Clinical Medicine, Aarhus University. Consultant and Head, Neuroradiology Research, Aarhus University Hospital.
www.cfin.au.dk
Professor and director, CFIN, Dept. Clinical Medicine, Aarhus University. Consultant and Head, Neuroradiology Research, Aarhus University Hospital.
www.cfin.au.dk
Congratulations - amazing work🤩!
Check out the newest paper from from Anders Sandgaard on Larmor frequency shifts in axons analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
Predicting Mesoscopic Larmor Frequency Shifts in White Matter With Diffusion MRI—A Monte Carlo Study in Axonal Phantoms
We aim to validate if MRI measures anisotropic mesoscopic Larmor frequency shifts from white matter axonal microstructure relative to B0 and if dMRI estimates this anisotropy. Recent models describe ...
analyticalsciencejournals.onlinelibrary.wiley.com
March 14, 2025 at 6:23 AM
Congratulations - amazing work🤩!
Nicolay Kutuzov is the final Hot Topic Poster presenter. He talks about super-localization two-photon microscopy for tracking blood vessel walls. Cool images🤩!
December 11, 2024 at 3:08 PM
Nicolay Kutuzov is the final Hot Topic Poster presenter. He talks about super-localization two-photon microscopy for tracking blood vessel walls. Cool images🤩!
Line Mathilde Brostrup Hansen talks about effects of age and sex on stroke outcomes in a mouse model (slight change from poster). After ischemia-reperfusion, older mice did worse - and sex needs to be taken into account. #CTH2024
December 11, 2024 at 2:56 PM
Line Mathilde Brostrup Hansen talks about effects of age and sex on stroke outcomes in a mouse model (slight change from poster). After ischemia-reperfusion, older mice did worse - and sex needs to be taken into account. #CTH2024
Hot Topic Poster presentation by Jacqueline Condrau on endothelial injury: microglia enwrap the injured capillary but this is not necessary for capillary repair. Neither were pericytes and astrocytes🤯. Answer? Neighbouring endothelial cell extensions.
December 11, 2024 at 2:34 PM
Hot Topic Poster presentation by Jacqueline Condrau on endothelial injury: microglia enwrap the injured capillary but this is not necessary for capillary repair. Neither were pericytes and astrocytes🤯. Answer? Neighbouring endothelial cell extensions.
Great talk by Yamei Tang on radiation-induced brain injury. Pericytes are extremely sensitive to radiation: Reduced pericyte coverage, signs of mural cell damage. Thalidomide treatment salvaged pericytes, capillaries, BBB integrity, neuronal function in mice🤩
Enormous translational potential!
Enormous translational potential!
December 11, 2024 at 1:41 PM
Great talk by Yamei Tang on radiation-induced brain injury. Pericytes are extremely sensitive to radiation: Reduced pericyte coverage, signs of mural cell damage. Thalidomide treatment salvaged pericytes, capillaries, BBB integrity, neuronal function in mice🤩
Enormous translational potential!
Enormous translational potential!
Eugenio Gutierrez-Jimenez presented a comprehensive study of carbonanhydrase inhibitor effects in the presymotomatic phase of Alzheimers Disease in a mouse model: reduces amyloid load, proteomic changes and hints of microvascular, oxygenation changes 🤩. #CTH2024. Out of battery😬)
See
See
December 11, 2024 at 1:24 PM
Eugenio Gutierrez-Jimenez presented a comprehensive study of carbonanhydrase inhibitor effects in the presymotomatic phase of Alzheimers Disease in a mouse model: reduces amyloid load, proteomic changes and hints of microvascular, oxygenation changes 🤩. #CTH2024. Out of battery😬)
See
See
Changing gears to look at human microvascular hemodynamics. Simon Fristed Eskildsen talks about microvascular flow disturbances in Alzheimers Disease and mild cognitive impairment (MCI). #CTH2024
December 11, 2024 at 12:12 PM
Changing gears to look at human microvascular hemodynamics. Simon Fristed Eskildsen talks about microvascular flow disturbances in Alzheimers Disease and mild cognitive impairment (MCI). #CTH2024
Tour de force through methods, models and concepts for understanding the BOLD signal by Michele Desjardins - amazing, multimodal and multidisciplinary work from Desjardin lab🤩. #CTH2024
December 11, 2024 at 10:42 AM
Tour de force through methods, models and concepts for understanding the BOLD signal by Michele Desjardins - amazing, multimodal and multidisciplinary work from Desjardin lab🤩. #CTH2024
Ravi Rungta presents cool studies of layer-specific flow responses in whisker barrel cortex 🤩. Why does vasodilation show little selectivity? Capillary dilation is tuned to downstream activity in layer 4.
December 11, 2024 at 9:51 AM
Ravi Rungta presents cool studies of layer-specific flow responses in whisker barrel cortex 🤩. Why does vasodilation show little selectivity? Capillary dilation is tuned to downstream activity in layer 4.
Mindblowing talk by Cristine Alberini: IGF-2 from pericytes is required for term memory formation. She points out that IGF-2 signaling is implicated in multiple brain disorders. Multiple opportunities for collaboration: neural plasticity - microvascular plasticity! #CTH2024
December 11, 2024 at 9:41 AM
Mindblowing talk by Cristine Alberini: IGF-2 from pericytes is required for term memory formation. She points out that IGF-2 signaling is implicated in multiple brain disorders. Multiple opportunities for collaboration: neural plasticity - microvascular plasticity! #CTH2024
Krzysztof Kucharz (Lauritzen Lab) is the third #CTH2024 Hot Topic presenter - about microvascular changes in an animal model of Huntingtons Disease - a devastating neurodegenerative disorder
December 10, 2024 at 3:35 PM
Krzysztof Kucharz (Lauritzen Lab) is the third #CTH2024 Hot Topic presenter - about microvascular changes in an animal model of Huntingtons Disease - a devastating neurodegenerative disorder
Anna Devor conceived and champions the #BrainMicrocirculation workshop’s Hot Topic Poster presentation sessions - giving early career researchers an opportunity to present their work and discuss their finding
December 10, 2024 at 3:28 PM
Anna Devor conceived and champions the #BrainMicrocirculation workshop’s Hot Topic Poster presentation sessions - giving early career researchers an opportunity to present their work and discuss their finding
Marine Tournissac (Charpak Lab) is the second Hot Topic Poster presenter. She investigated the difference between CO2- and brain activation- related hyperemia
December 10, 2024 at 3:18 PM
Marine Tournissac (Charpak Lab) is the second Hot Topic Poster presenter. She investigated the difference between CO2- and brain activation- related hyperemia
Hot Topic Poster presentation #CTH2024 -
Kevin Elk (Mishra lab) is the first of 6 posters selected for an oral presentation - at very short notice😬!
Great talk on pericyte function!
Kevin Elk (Mishra lab) is the first of 6 posters selected for an oral presentation - at very short notice😬!
Great talk on pericyte function!
December 10, 2024 at 2:59 PM
Hot Topic Poster presentation #CTH2024 -
Kevin Elk (Mishra lab) is the first of 6 posters selected for an oral presentation - at very short notice😬!
Great talk on pericyte function!
Kevin Elk (Mishra lab) is the first of 6 posters selected for an oral presentation - at very short notice😬!
Great talk on pericyte function!
Mickael Tanter: Clinical application-impressive 🤩!
Micro bubbles are 3 micrometers.
Micro bubbles are 3 micrometers.
December 10, 2024 at 2:38 PM
Mickael Tanter: Clinical application-impressive 🤩!
Micro bubbles are 3 micrometers.
Micro bubbles are 3 micrometers.
Mickael Tanter presents amazing ultrasound images of the brain circulation - and brain activity 🤩
December 10, 2024 at 2:13 PM
Mickael Tanter presents amazing ultrasound images of the brain circulation - and brain activity 🤩
Franca Schmid presents amazing model findings that increase our understanding of the importance of collaterals and of what happens after pericyte loss and capillary occlusions.
Take home from modeling talks: we need more detailed images of microvascular trees - especially in deep cortex layers.
Take home from modeling talks: we need more detailed images of microvascular trees - especially in deep cortex layers.
December 10, 2024 at 2:09 PM
Franca Schmid presents amazing model findings that increase our understanding of the importance of collaterals and of what happens after pericyte loss and capillary occlusions.
Take home from modeling talks: we need more detailed images of microvascular trees - especially in deep cortex layers.
Take home from modeling talks: we need more detailed images of microvascular trees - especially in deep cortex layers.
Sylvie Lorthois gives impressive talk on modeling the microcirculation - long transit times and poor oxygenation/amyloid removal may be more common - and harder to measure - than we believe
#CTH2024
#CTH2024
December 10, 2024 at 1:39 PM
Sylvie Lorthois gives impressive talk on modeling the microcirculation - long transit times and poor oxygenation/amyloid removal may be more common - and harder to measure - than we believe
#CTH2024
#CTH2024
Timothy Secomb, a giant within our understanding of blood flow and oxygen transport in microvascular networks, kicks off the modeling session🤩 #CTH2024
December 10, 2024 at 1:29 PM
Timothy Secomb, a giant within our understanding of blood flow and oxygen transport in microvascular networks, kicks off the modeling session🤩 #CTH2024
Vladimir Matchkov talks about capillary hemodynamics and neuro vascular coupling after ischemia-reperfusion.
December 10, 2024 at 10:30 AM
Vladimir Matchkov talks about capillary hemodynamics and neuro vascular coupling after ischemia-reperfusion.
Anusha Mishra presents impressive work on neuro vascular coupling - and how it changes after stroke. Huge translational implications for vascular and Alzheimers dementia #CTH2024
December 10, 2024 at 10:15 AM
Anusha Mishra presents impressive work on neuro vascular coupling - and how it changes after stroke. Huge translational implications for vascular and Alzheimers dementia #CTH2024
Anusha Mishra presents impressive work on neuro vascular coupling - and how it changes after stroke. Huge translational implications for vascular and Alzheimers dementia #CTH2024
December 10, 2024 at 10:15 AM
Anusha Mishra presents impressive work on neuro vascular coupling - and how it changes after stroke. Huge translational implications for vascular and Alzheimers dementia #CTH2024
#BrainMicrocirculation session starting
December 10, 2024 at 9:39 AM
#BrainMicrocirculation session starting
Poster session at the #BrainMicrocirculation workshop #CTH2024☕️
December 10, 2024 at 9:37 AM
Poster session at the #BrainMicrocirculation workshop #CTH2024☕️