@stephaniebonney.bsky.social
Assistant Professor | Department of Anesthesiology | University of Colorado Anschutz
Studying the role of brain perivascular fibroblasts in regulating vascular integrity and dynamics in health and small vessel disease
Studying the role of brain perivascular fibroblasts in regulating vascular integrity and dynamics in health and small vessel disease
Reposted
New finding from the lab. This surprised us since it went against the common assumption that increasing peri-infarct blood flow is best for stroke recovery. Congrats to Kamal and the team!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood brain barrier disruption
Focal stroke leads to complex changes in the cerebral microcirculation in surviving brain tissues that strongly influence recovery. Plasminogen activator inhibitor-1 (PAI-1; encoded by Serpine1) is hi...
www.biorxiv.org
October 16, 2025 at 6:03 PM
New finding from the lab. This surprised us since it went against the common assumption that increasing peri-infarct blood flow is best for stroke recovery. Congrats to Kamal and the team!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
1/5: How does a presumably redundant microRNA contribute to mammalian brain development and neurodevelopmental disease? Check out our new work led by Dr. Santiago Fregoso now on bioRxiv! www.biorxiv.org/content/10.1... #Neurodev #miRNA #hydrocephalus #Genetics #bioRxiv.
Loss of miR-9-2 Causes Cerebral Hemorrhage and Hydrocephalus by Widespread Disruption of Cell-Type-Specific Neurodevelopmental Gene Networks.
MIR-9-2 is a broadly and highly expressed microRNA in the developing brain and is frequently deleted in 5q14.3 Microdeletion Syndrome, a rare but severe neurodevelopmental disorder. Despite this, litt...
www.biorxiv.org
August 2, 2025 at 12:02 AM
1/5: How does a presumably redundant microRNA contribute to mammalian brain development and neurodevelopmental disease? Check out our new work led by Dr. Santiago Fregoso now on bioRxiv! www.biorxiv.org/content/10.1... #Neurodev #miRNA #hydrocephalus #Genetics #bioRxiv.