Srustidhar Das
@srudas.bsky.social
Stem cell biologist | Organoid aficionado | History enthusiast | Exploring tissue homeostasis at the intersection of regeneration & cancer
Fantastic work, huge congratulations @katajistolab.bsky.social !!!
July 14, 2025 at 11:50 PM
Fantastic work, huge congratulations @katajistolab.bsky.social !!!
Can I also join please!!!
December 6, 2024 at 2:56 PM
Can I also join please!!!
On a personal note - this work was a labor of love spanning over 7 years. I’m now on the #jobmarket, looking to start my own group and further explore how tissue homeostasis is maintained in the gut and beyond.
Would love to hear about any potential opportunity! #newbeginning
Would love to hear about any potential opportunity! #newbeginning
November 25, 2024 at 11:40 PM
On a personal note - this work was a labor of love spanning over 7 years. I’m now on the #jobmarket, looking to start my own group and further explore how tissue homeostasis is maintained in the gut and beyond.
Would love to hear about any potential opportunity! #newbeginning
Would love to hear about any potential opportunity! #newbeginning
Grateful to our funders— @Cancerfonden @Åke Weibergs Stiftelse @FormasForsk @Vetenskapsradet @ERC_Research @Wstiftelserna @reNEW_Global
@EUbOPEN - for making this work possible!
@EUbOPEN - for making this work possible!
November 25, 2024 at 11:40 PM
Grateful to our funders— @Cancerfonden @Åke Weibergs Stiftelse @FormasForsk @Vetenskapsradet @ERC_Research @Wstiftelserna @reNEW_Global
@EUbOPEN - for making this work possible!
@EUbOPEN - for making this work possible!
Thank you @ barbmarte.bsky.social @ natureportfolio.bsky.social, and our fantastic reviewers who helped shape the paper into its final form.
November 25, 2024 at 11:40 PM
Thank you @ barbmarte.bsky.social @ natureportfolio.bsky.social, and our fantastic reviewers who helped shape the paper into its final form.
A heartfelt thanks to @ ejvillablanca.bsky.social @ karolinskainst.bsky.social, for the trust, freedom to challenge the status quo, and unwavering support throughout this long journey! 🙌✨
November 25, 2024 at 11:40 PM
A heartfelt thanks to @ ejvillablanca.bsky.social @ karolinskainst.bsky.social, for the trust, freedom to challenge the status quo, and unwavering support throughout this long journey! 🙌✨
A huge shoutout to all co-authors, especially@martinaparigi.bsky.social and@xinxinluo.bsky.social-two amazing colleagues and co-first authors I had the privilege to work with - and to all our collaborators. Special thanks to@katajistolab.bsky.social for teaching us the art of growing #organoids! 🙌✨
November 25, 2024 at 11:40 PM
A huge shoutout to all co-authors, especially@martinaparigi.bsky.social and@xinxinluo.bsky.social-two amazing colleagues and co-first authors I had the privilege to work with - and to all our collaborators. Special thanks to@katajistolab.bsky.social for teaching us the art of growing #organoids! 🙌✨
We uncovered a pathway that unlinks #regeneration and #tumorigenesis – a discovery with profound implications for #regenerativemedicine. This holds promise for #IBD, #cancer, and beyond!
November 25, 2024 at 11:40 PM
We uncovered a pathway that unlinks #regeneration and #tumorigenesis – a discovery with profound implications for #regenerativemedicine. This holds promise for #IBD, #cancer, and beyond!
Next, we explored how is LXR activated endogenously. Revisiting our #transcriptomics datasets from damage-repair models, we uncovered a key player: #CYP27A1, a cholesterol-metabolizing enzyme. It’s induced by damage and acts upstream of LXR – a critical piece of the puzzle!
November 25, 2024 at 11:40 PM
Next, we explored how is LXR activated endogenously. Revisiting our #transcriptomics datasets from damage-repair models, we uncovered a key player: #CYP27A1, a cholesterol-metabolizing enzyme. It’s induced by damage and acts upstream of LXR – a critical piece of the puzzle!
How does LXR activation inhibit tumorigenesis?
Using longitudinal #bulk & #spatialtranscriptomics, we found LXR bolsters adaptive immunity - supporting B cells & CD8+ T cells to suppress tumor growth.
Using longitudinal #bulk & #spatialtranscriptomics, we found LXR bolsters adaptive immunity - supporting B cells & CD8+ T cells to suppress tumor growth.
November 25, 2024 at 11:40 PM
How does LXR activation inhibit tumorigenesis?
Using longitudinal #bulk & #spatialtranscriptomics, we found LXR bolsters adaptive immunity - supporting B cells & CD8+ T cells to suppress tumor growth.
Using longitudinal #bulk & #spatialtranscriptomics, we found LXR bolsters adaptive immunity - supporting B cells & CD8+ T cells to suppress tumor growth.
Interestingly, during tumorigenesis, LXR activation doesn’t induce AREG or similar EGFR ligands. Something to explore in the future! 🤔
November 25, 2024 at 11:40 PM
Interestingly, during tumorigenesis, LXR activation doesn’t induce AREG or similar EGFR ligands. Something to explore in the future! 🤔
How does LXR promote regeneration?🤔
Using #scRNAseq and #organoids, we found that LXR induces amphiregulin – an EGFR ligand – in epithelial cells (previously understudied cellular source), to promote regeneration, and was validated with AREG KO mice and neutralizing antibody.
Using #scRNAseq and #organoids, we found that LXR induces amphiregulin – an EGFR ligand – in epithelial cells (previously understudied cellular source), to promote regeneration, and was validated with AREG KO mice and neutralizing antibody.
November 25, 2024 at 11:40 PM
How does LXR promote regeneration?🤔
Using #scRNAseq and #organoids, we found that LXR induces amphiregulin – an EGFR ligand – in epithelial cells (previously understudied cellular source), to promote regeneration, and was validated with AREG KO mice and neutralizing antibody.
Using #scRNAseq and #organoids, we found that LXR induces amphiregulin – an EGFR ligand – in epithelial cells (previously understudied cellular source), to promote regeneration, and was validated with AREG KO mice and neutralizing antibody.
Does it increase tumor risk? 🤔
Unlike other pro-regenerative modulators, LXR activation inhibited tumorigenesis – an #unlinker of #regeneration and #tumorigenesis!
Unlike other pro-regenerative modulators, LXR activation inhibited tumorigenesis – an #unlinker of #regeneration and #tumorigenesis!
November 25, 2024 at 11:40 PM
Does it increase tumor risk? 🤔
Unlike other pro-regenerative modulators, LXR activation inhibited tumorigenesis – an #unlinker of #regeneration and #tumorigenesis!
Unlike other pro-regenerative modulators, LXR activation inhibited tumorigenesis – an #unlinker of #regeneration and #tumorigenesis!
Using #invivo gain and loss-of-function studies and #invitro #organoids, we showed that LXR activation in intestinal epithelial cells (IECs) promotes intestinal regeneration.
November 25, 2024 at 11:40 PM
Using #invivo gain and loss-of-function studies and #invitro #organoids, we showed that LXR activation in intestinal epithelial cells (IECs) promotes intestinal regeneration.