@soundsoundso.bsky.social
there’s overlap between biology in acute infection and in these disorders. Can’t psychoneuroimmunological and neuroendocrinological models help explain the elevated risk of chronicity and persistence of post-viral conditions?
October 12, 2025 at 8:59 AM
there’s overlap between biology in acute infection and in these disorders. Can’t psychoneuroimmunological and neuroendocrinological models help explain the elevated risk of chronicity and persistence of post-viral conditions?
Aren’t psychiatric disorders—anxiety disorders in particular—among the stronger risk factors for developing Long COVID, after the severity and number of acute-phase symptoms? Not saying it’s ‘all in the head or just anxiety and depression,’ but as far as I am capable of understanding the literature,
October 12, 2025 at 8:58 AM
Aren’t psychiatric disorders—anxiety disorders in particular—among the stronger risk factors for developing Long COVID, after the severity and number of acute-phase symptoms? Not saying it’s ‘all in the head or just anxiety and depression,’ but as far as I am capable of understanding the literature,
Great. Thanks!
October 7, 2025 at 8:39 PM
Great. Thanks!
Would u be okay with me posting a link to your thread on this study under the article by „Deutsches Ärzteblatt“. It’s the German Medical Associations official publication.
The information u are giving could be relevant for others. Totally understand if u don’t want to be part of X turmoil though.
The information u are giving could be relevant for others. Totally understand if u don’t want to be part of X turmoil though.
October 7, 2025 at 6:30 PM
Would u be okay with me posting a link to your thread on this study under the article by „Deutsches Ärzteblatt“. It’s the German Medical Associations official publication.
The information u are giving could be relevant for others. Totally understand if u don’t want to be part of X turmoil though.
The information u are giving could be relevant for others. Totally understand if u don’t want to be part of X turmoil though.
… without being critical towards the findings.
As a non expert it’s not always easy to differentiate.
As a non expert it’s not always easy to differentiate.
October 7, 2025 at 2:04 PM
… without being critical towards the findings.
As a non expert it’s not always easy to differentiate.
As a non expert it’s not always easy to differentiate.
Guess I missed that post back then. Thank you for putting your time into this over and over again.
It’s too many people using these studies to scare others, get attention or whatever other intention they might be having. In this case the „Deutsche Ärzteblatt“ actually had a news report on it …
It’s too many people using these studies to scare others, get attention or whatever other intention they might be having. In this case the „Deutsche Ärzteblatt“ actually had a news report on it …
October 7, 2025 at 2:02 PM
Guess I missed that post back then. Thank you for putting your time into this over and over again.
It’s too many people using these studies to scare others, get attention or whatever other intention they might be having. In this case the „Deutsche Ärzteblatt“ actually had a news report on it …
It’s too many people using these studies to scare others, get attention or whatever other intention they might be having. In this case the „Deutsche Ärzteblatt“ actually had a news report on it …
Thanks for clarifying!
October 7, 2025 at 1:17 PM
Thanks for clarifying!
Thanks!
Why is the incidence being at 0.09% in the control group interesting?
Why is the incidence being at 0.09% in the control group interesting?
October 7, 2025 at 9:06 AM
Thanks!
Why is the incidence being at 0.09% in the control group interesting?
Why is the incidence being at 0.09% in the control group interesting?
This study is making the rounds as it’s findings are that „Reinfection was associated with a significantly increased risk of an overall PASC diagnosis“. Would that be data that would change your opinion or does context interpretation and methodology matter here
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Long COVID associated with SARS-CoV-2 reinfection among children and adolescents in the omicron era (RECOVER-EHR): a retrospective cohort study
Children and adolescents face a significantly higher risk of various PASC outcomes
after reinfection with SARS-CoV-2. These findings add to previous evidence linking
paediatric long COVID to multisyst...
www.thelancet.com
October 7, 2025 at 8:48 AM
This study is making the rounds as it’s findings are that „Reinfection was associated with a significantly increased risk of an overall PASC diagnosis“. Would that be data that would change your opinion or does context interpretation and methodology matter here
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
As you were saying that debris accumulates triggering sustained activation of resident microglia cells in the olfactory epithelium and part of the idea in the study was that PEA modulates the microglial response, potentially reducing inflammation in the olfactory bulb I thought there might be a link
August 26, 2025 at 7:15 PM
As you were saying that debris accumulates triggering sustained activation of resident microglia cells in the olfactory epithelium and part of the idea in the study was that PEA modulates the microglial response, potentially reducing inflammation in the olfactory bulb I thought there might be a link
Thank you for sharing your knowledge. Does this study make some sense in this context? link.springer.com/article/10.1...
Treatment of COVID-19 olfactory dysfunction with olfactory training, palmitoylethanolamide with luteolin, or combined therapy: a blinded controlled multicenter randomized trial - European Archives of ...
Purpose Few evidence-based therapies are available for chronic olfactory dysfunction after COVID-19. This study investigated the relative efficacy of olfactory training alone, co-ultramicronized palmi...
link.springer.com
August 26, 2025 at 3:51 PM
Thank you for sharing your knowledge. Does this study make some sense in this context? link.springer.com/article/10.1...
Thanks for sharing. If I got it right, the study observed effects up to 30 days post infection.
What could be keeping these mechanism going in some individuals while clearing in others after a few weeks?
What could be keeping these mechanism going in some individuals while clearing in others after a few weeks?
August 5, 2025 at 7:30 AM
Thanks for sharing. If I got it right, the study observed effects up to 30 days post infection.
What could be keeping these mechanism going in some individuals while clearing in others after a few weeks?
What could be keeping these mechanism going in some individuals while clearing in others after a few weeks?
Absolutely, it is also seen in depression e.g..There’s a lot to untangle.
But a patient advocacy group claiming patients being blamed and scientific research trying to understand, looking for causes and relations are two very different phenomena
But a patient advocacy group claiming patients being blamed and scientific research trying to understand, looking for causes and relations are two very different phenomena
May 11, 2025 at 9:51 AM
Absolutely, it is also seen in depression e.g..There’s a lot to untangle.
But a patient advocacy group claiming patients being blamed and scientific research trying to understand, looking for causes and relations are two very different phenomena
But a patient advocacy group claiming patients being blamed and scientific research trying to understand, looking for causes and relations are two very different phenomena
Not really sure if the scientific objective is to blame patients. It is rather identifying mechanisms and relations, ideally so treatments can be developed.
Everyone is exposed from birth but only some develop these conditions. Not considering all plausible options wouldn’t be very supportive
Everyone is exposed from birth but only some develop these conditions. Not considering all plausible options wouldn’t be very supportive
May 11, 2025 at 9:43 AM
Not really sure if the scientific objective is to blame patients. It is rather identifying mechanisms and relations, ideally so treatments can be developed.
Everyone is exposed from birth but only some develop these conditions. Not considering all plausible options wouldn’t be very supportive
Everyone is exposed from birth but only some develop these conditions. Not considering all plausible options wouldn’t be very supportive
possible, yes. Personally I am skeptical if its a one way train. Particularly when looking at pre-infection situations. There is immune mediated sickness behavior, that apparently shows some traits of depression. But there is clearly a broad range of emotional stressors that can cause anxiety dis.
May 11, 2025 at 7:43 AM
possible, yes. Personally I am skeptical if its a one way train. Particularly when looking at pre-infection situations. There is immune mediated sickness behavior, that apparently shows some traits of depression. But there is clearly a broad range of emotional stressors that can cause anxiety dis.
I am assuming that that’s part of why you are trying to keep the discussion balanced and criticize LC-denialism as well as fear mongering.
Too bad much of the public (and parts of the scientific?) discourse got stuck in a dualistic game of ping-pong.
Thank you for your time, Marc!
Too bad much of the public (and parts of the scientific?) discourse got stuck in a dualistic game of ping-pong.
Thank you for your time, Marc!
May 10, 2025 at 11:01 AM
I am assuming that that’s part of why you are trying to keep the discussion balanced and criticize LC-denialism as well as fear mongering.
Too bad much of the public (and parts of the scientific?) discourse got stuck in a dualistic game of ping-pong.
Thank you for your time, Marc!
Too bad much of the public (and parts of the scientific?) discourse got stuck in a dualistic game of ping-pong.
Thank you for your time, Marc!
As particularly a pre existing anxiety disorder has been shown to bear an increased risk for developing such syndromes & as long term psychological distress has shown to have an impact on the immune and nervous system, do you think dysfunctional feedback loops may be a factor (not the sole cause)?
May 10, 2025 at 10:09 AM
As particularly a pre existing anxiety disorder has been shown to bear an increased risk for developing such syndromes & as long term psychological distress has shown to have an impact on the immune and nervous system, do you think dysfunctional feedback loops may be a factor (not the sole cause)?
Interesting, thanks!
So you are saying it is hard to explain sustaining & additional symptoms through the slightly heightened immune activity observed? And that it is „post infection associated“. Implicating that the initial immune activity is not necessarily directly linked to symptoms in PIAS?
So you are saying it is hard to explain sustaining & additional symptoms through the slightly heightened immune activity observed? And that it is „post infection associated“. Implicating that the initial immune activity is not necessarily directly linked to symptoms in PIAS?
May 10, 2025 at 9:05 AM
Interesting, thanks!
So you are saying it is hard to explain sustaining & additional symptoms through the slightly heightened immune activity observed? And that it is „post infection associated“. Implicating that the initial immune activity is not necessarily directly linked to symptoms in PIAS?
So you are saying it is hard to explain sustaining & additional symptoms through the slightly heightened immune activity observed? And that it is „post infection associated“. Implicating that the initial immune activity is not necessarily directly linked to symptoms in PIAS?
Thanks. I made that assumption as the symptoms with high RR in these findings were more prevalent in earlier variants.
As you are saying immune response to pathogen is likely a trigger. Do you think the factors sustaining the immune system being disbalanced could be distinguished from the trigger?
As you are saying immune response to pathogen is likely a trigger. Do you think the factors sustaining the immune system being disbalanced could be distinguished from the trigger?
May 10, 2025 at 7:31 AM
Thanks. I made that assumption as the symptoms with high RR in these findings were more prevalent in earlier variants.
As you are saying immune response to pathogen is likely a trigger. Do you think the factors sustaining the immune system being disbalanced could be distinguished from the trigger?
As you are saying immune response to pathogen is likely a trigger. Do you think the factors sustaining the immune system being disbalanced could be distinguished from the trigger?
So are these findings basically saying that early variants show a higher risk of developing LC?
Could that be somehow associated with the stronger innate immune and inflammatory response typically seen in these variants?
Thanks!
Could that be somehow associated with the stronger innate immune and inflammatory response typically seen in these variants?
Thanks!
May 10, 2025 at 5:54 AM
So are these findings basically saying that early variants show a higher risk of developing LC?
Could that be somehow associated with the stronger innate immune and inflammatory response typically seen in these variants?
Thanks!
Could that be somehow associated with the stronger innate immune and inflammatory response typically seen in these variants?
Thanks!
Great read! Thank you for making these topics accessible and comprehensible for people without immunological or medical expertise!
April 14, 2025 at 5:41 AM
Great read! Thank you for making these topics accessible and comprehensible for people without immunological or medical expertise!
far as I can comprehend he suggests somewhat of a multidirectional theory. At least that’s how I would describe it in two words.
February 25, 2025 at 7:11 PM
far as I can comprehend he suggests somewhat of a multidirectional theory. At least that’s how I would describe it in two words.
Thanks a lot you for the reply. As you often emphasize the difficulties in identifying causalities regarding the immunological markers studies often observe I thought it might provide some hypotheses on why proving causalities might be that difficult. I am no medical professional or anything but as
February 25, 2025 at 7:10 PM
Thanks a lot you for the reply. As you often emphasize the difficulties in identifying causalities regarding the immunological markers studies often observe I thought it might provide some hypotheses on why proving causalities might be that difficult. I am no medical professional or anything but as
theories he mentions when it comes to providing some explanation for the immunological aspects we are seeing in LC. Thanks!
February 25, 2025 at 3:30 PM
theories he mentions when it comes to providing some explanation for the immunological aspects we are seeing in LC. Thanks!
Thanks a lot for all of the great explanations you are constantly providing! I’m not sure wether or not you are familiar with the book „The Inflamed Feeling“ by Mats Lekander and the neuropsychoimmunological hypotheses mentioned within it. But I was wondering what your thoughts would be on the
February 25, 2025 at 3:29 PM
Thanks a lot for all of the great explanations you are constantly providing! I’m not sure wether or not you are familiar with the book „The Inflamed Feeling“ by Mats Lekander and the neuropsychoimmunological hypotheses mentioned within it. But I was wondering what your thoughts would be on the