Sonu Abraham
@sonuabrahammd.bsky.social
HF Cardiologist @GillKentucky via @NMCardioVasc, @LaheyHospital, @svhmedres @CalicutCollege | @Circulation #SoMeEditor | #InfiltrativeCMs | #HCM | #CardiogenicShock
August 29, 2025 at 3:02 PM
💥 The coexistence of IEVs with monogenic variants leads to a more aggressive HCM phenotype: earlier onset, greater hypertrophy, and reduced survival (MACE-free: 69% vs 93% at 70 yrs).
💥 Clinical takeaway: IEV assessment could be considered as part of HCM genetic testing.
💥 Clinical takeaway: IEV assessment could be considered as part of HCM genetic testing.
August 29, 2025 at 2:52 PM
💥 The coexistence of IEVs with monogenic variants leads to a more aggressive HCM phenotype: earlier onset, greater hypertrophy, and reduced survival (MACE-free: 69% vs 93% at 70 yrs).
💥 Clinical takeaway: IEV assessment could be considered as part of HCM genetic testing.
💥 Clinical takeaway: IEV assessment could be considered as part of HCM genetic testing.
⚡ Clinically, IEV carriers had:
👉 Earlier diagnosis (59 vs 61 yrs)
👉 Thicker LV walls
👉 Higher risk of adverse events
➡️ IEVs aren’t “benign” passengers—they modulate disease severity. #SoMeEditor
👉 Earlier diagnosis (59 vs 61 yrs)
👉 Thicker LV walls
👉 Higher risk of adverse events
➡️ IEVs aren’t “benign” passengers—they modulate disease severity. #SoMeEditor
August 29, 2025 at 2:52 PM
⚡ Clinically, IEV carriers had:
👉 Earlier diagnosis (59 vs 61 yrs)
👉 Thicker LV walls
👉 Higher risk of adverse events
➡️ IEVs aren’t “benign” passengers—they modulate disease severity. #SoMeEditor
👉 Earlier diagnosis (59 vs 61 yrs)
👉 Thicker LV walls
👉 Higher risk of adverse events
➡️ IEVs aren’t “benign” passengers—they modulate disease severity. #SoMeEditor
🧬 In >10k HCM cases vs >590k controls, 14 IEVs were identified across 8 genes.
🧬 Strikingly, 65% were in non-sarcomeric genes.
🧬 Contribution to HCM burden? 4.9%. #Genetics #HCM #SoMeEditor
🧬 Strikingly, 65% were in non-sarcomeric genes.
🧬 Contribution to HCM burden? 4.9%. #Genetics #HCM #SoMeEditor
August 29, 2025 at 2:52 PM
🧬 In >10k HCM cases vs >590k controls, 14 IEVs were identified across 8 genes.
🧬 Strikingly, 65% were in non-sarcomeric genes.
🧬 Contribution to HCM burden? 4.9%. #Genetics #HCM #SoMeEditor
🧬 Strikingly, 65% were in non-sarcomeric genes.
🧬 Contribution to HCM burden? 4.9%. #Genetics #HCM #SoMeEditor