Solène Hervé
@sol-herve.bsky.social
Postdoc @ Buchwalter lab, UCSF
Former Postdoc @ Miroshnikova lab, NIH
PhD @ Fachinetti lab, Institut Curie.
nuclear mechanobiology | lamins | microscopy | organoids | genome instability | colorectal cancer
Former Postdoc @ Miroshnikova lab, NIH
PhD @ Fachinetti lab, Institut Curie.
nuclear mechanobiology | lamins | microscopy | organoids | genome instability | colorectal cancer
Check out our new study showing that p53 can be activated after chromosome mis-segregation, surprisingly not by DNA damage, but by altered nuclear mechanics during nucleus reformation at mitotic exit. Congrats to all, especially Andrea Scelfo, @dfachinetti.bsky.social and @katemiro.bsky.social!
#1 Happy to share our last work published in @NatureCellBio about a new cell cycle checkpoint that senses nuclear shape & mechanics to guarantee genome integrity
www.nature.com/articles/s41.... Great work from @sol-herve.bsky.social & Andrea Scelfo in close collaboration with @katemiro.bsky.social
www.nature.com/articles/s41.... Great work from @sol-herve.bsky.social & Andrea Scelfo in close collaboration with @katemiro.bsky.social
Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint - Nature Cell Biology
Hervé, Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochrom...
www.nature.com
January 8, 2025 at 3:05 PM
Check out our new study showing that p53 can be activated after chromosome mis-segregation, surprisingly not by DNA damage, but by altered nuclear mechanics during nucleus reformation at mitotic exit. Congrats to all, especially Andrea Scelfo, @dfachinetti.bsky.social and @katemiro.bsky.social!