A 100% Complete Response Rate Shows Promise--85% of mice also achieved histologic cure. 1 and 2-cycle treatments were equally effective and well-tolerated. In the patient xenograft, a single 225Ac treatment achieved a 60% response and prolonged survival compared to no treatment.

Though previous studies have shown that HER2-targeted radiotherapies with the alpha-particle-emitting radionuclide 225Ac were effective, they were not safe for patients, as 225Ac was retained in the body, causing high toxicity.

FEATURED: CXCR4 PET/CT Predicts Left Ventricular Recovery 8 Months After Acute Myocardial Infarction: jnm.snmjournals.org/content/66/1...

FEATURED: 225Ac α-Pretargeted Radioimmunotherapy of Human Epidermal Growth Factor Receptor 2–Expressing Breast Cancer: jnm.snmjournals.org/content/66/1...

The State of the Art: Comparison, Agreement, and Significance Cutoffs of 18F-Flurpiridaz PET Myocardial Blood Flow Quantitation Methods and Software Packages: jnm.snmjournals.org/content/66/1...

Discussions with Leaders: Translating Research Amidst Transnational Quarrels: jnm.snmjournals.org/content/66/1...

Such great timing!

PODCAST: Biomarkers in Prostate Cancer: What's in the blood? 👉 youtu.be/IpaEwpSA2kY?...

FEATURED: Lesion Absorbed Dose–Response Relationship in Patients with Metastatic Castration-Resistant Prostate Cancer Undergoing [177Lu]Lu-PSMA-617 Radiopharmaceutical Therapy 👉https://jnm.snmjournals.org/content/66/10/1622

FEATURED: Efficacy and Safety of [177Lu]Lu-DOTAGA.Glu.(FAPi)2 Therapy in Patients with Sarcoma 👉 jnm.snmjournals.org/content/66/1...

The State of the Art: Standardization of PET/CT Performance Requirements for Whole-Body Quantitative Imaging: An International Proposal 👉https://jnm.snmjournals.org/content/66/10/1506

Discussions with Leaders: From Nuclear Medicine Specialist to Cancer Center Director with Jeremie Calais 👉 jnm.snmjournals.org/content/66/1...