THIS IS HUGE! TWO Phase I HIV vaccine clinical trials have demonstrated that a stepwise mRNA-based vaccination strategy can SUCCESSFULLY activate AND advance immune responses toward producing broadly neutralizing antibodies (bnAbs), a CRITICAL milestone in HIV prevention. Let’s talk about that! 🧪🧵⬇️

Phase 1 trial: a recombinant, SOSIP-stable germline-targeting HIV Env trimer adjuvanted with AS01B, induced VRC01-class bnAb precursors at high frequency that had undergone characteristic SHM @science.org @tomcaniels.bsky.social
www.science.org/doi/10.1126/...