Sleebs Laboratory
@sleebslab.bsky.social
Medicinal Chemistry Laboratory active in the Infectious Diseases Field
Please to share #Sleebs_Lab #WEHI_research latest research led my #Madeline_Dans and #Wenyin_Su demonstrating the on-target activity of plasmepsin V peptidomimetics in Plasmodium falciparum parasites using genetic and proteomic approaches.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Deconvolution of the On-Target Activity of Plasmepsin V Peptidomimetics in Plasmodium falciparum Parasites
Plasmepsin V (PMV), an essential aspartyl protease, plays a critical role during the asexual blood stage of infection of Plasmodium by enabling the export of parasite proteins into the host red blood ...
pubs.acs.org
December 11, 2025 at 2:01 AM
Please to share #Sleebs_Lab #WEHI_research latest research led my #Madeline_Dans and #Wenyin_Su demonstrating the on-target activity of plasmepsin V peptidomimetics in Plasmodium falciparum parasites using genetic and proteomic approaches.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Please #Sleebs_Lab #WEHI_research has contributed to a review at #npjAMR led by Emma Mao @UniofAdelaide on the contribution of natural products to the drugs approved to treat disease caused by apicomplexan parasites
www.nature.com/articles/s44...
www.nature.com/articles/s44...
A review of natural products as a source of next-generation drugs against apicomplexan parasites - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - A review of natural products as a source of next-generation drugs against apicomplexan parasites
www.nature.com
July 22, 2025 at 10:39 PM
Please #Sleebs_Lab #WEHI_research has contributed to a review at #npjAMR led by Emma Mao @UniofAdelaide on the contribution of natural products to the drugs approved to treat disease caused by apicomplexan parasites
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Pleased to see our research is published #Sleebs_Lab #WEHI_research led by William Nguyen on the optimization of an antimalarial class that targets ROM8 & CSC1
...stay tuned for more research on the intriguing role of ROM8 & CSC1 in parasite survival...
pubs.acs.org/doi/10.1021/...
...stay tuned for more research on the intriguing role of ROM8 & CSC1 in parasite survival...
pubs.acs.org/doi/10.1021/...
Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1
New antimalarials are needed due to the threat of emerging resistance against existing antimalarial therapies. A phenotypic screen uncovered the N-aryl acetamide class that inhibits the development of...
pubs.acs.org
July 22, 2025 at 10:23 PM
Pleased to see our research is published #Sleebs_Lab #WEHI_research led by William Nguyen on the optimization of an antimalarial class that targets ROM8 & CSC1
...stay tuned for more research on the intriguing role of ROM8 & CSC1 in parasite survival...
pubs.acs.org/doi/10.1021/...
...stay tuned for more research on the intriguing role of ROM8 & CSC1 in parasite survival...
pubs.acs.org/doi/10.1021/...
Pleased to see the review lead by Harry Shanley
@sleebslab.bsky.social @wehi-research.bsky.social
in collaboration with the Gasser Lab @UniMelb on Advances in Anthelmintic Target Identification is now published. mdpi.com/3270800 #mdpiijms
@sleebslab.bsky.social @wehi-research.bsky.social
in collaboration with the Gasser Lab @UniMelb on Advances in Anthelmintic Target Identification is now published. mdpi.com/3270800 #mdpiijms
April 25, 2025 at 7:54 AM
Pleased to see the review lead by Harry Shanley
@sleebslab.bsky.social @wehi-research.bsky.social
in collaboration with the Gasser Lab @UniMelb on Advances in Anthelmintic Target Identification is now published. mdpi.com/3270800 #mdpiijms
@sleebslab.bsky.social @wehi-research.bsky.social
in collaboration with the Gasser Lab @UniMelb on Advances in Anthelmintic Target Identification is now published. mdpi.com/3270800 #mdpiijms
Pleased to see our research @sleebslab.bsky.social @wehi-research.bsky.social lead by Tony Hodder on the structural analysis of dual plasmepsin V and plasmepsin X inhibitors is now online at FEBS.
febs.onlinelibrary.wiley.com/doi/full/10....
febs.onlinelibrary.wiley.com/doi/full/10....
FEBS Press
Compounds were identified that inhibit the aspartic protease plasmepsin V from Plasmodium vivax. Further development of these compounds identified compounds, such as S-WM48, that could inhibit both p....
febs.onlinelibrary.wiley.com
April 25, 2025 at 7:53 AM
Pleased to see our research @sleebslab.bsky.social @wehi-research.bsky.social lead by Tony Hodder on the structural analysis of dual plasmepsin V and plasmepsin X inhibitors is now online at FEBS.
febs.onlinelibrary.wiley.com/doi/full/10....
febs.onlinelibrary.wiley.com/doi/full/10....
Pleased @sleebslab.bsky.social @wehi-research.bsky.social
has contributed to research led by Aya Taki @UniMelb
on the prediction and prioritization of novel anthelmintic candidates using deep learning is published at Int J Mol Sci. mdpi.com/3245704 #mdpiijms
has contributed to research led by Aya Taki @UniMelb
on the prediction and prioritization of novel anthelmintic candidates using deep learning is published at Int J Mol Sci. mdpi.com/3245704 #mdpiijms
April 25, 2025 at 7:51 AM
Pleased @sleebslab.bsky.social @wehi-research.bsky.social
has contributed to research led by Aya Taki @UniMelb
on the prediction and prioritization of novel anthelmintic candidates using deep learning is published at Int J Mol Sci. mdpi.com/3245704 #mdpiijms
has contributed to research led by Aya Taki @UniMelb
on the prediction and prioritization of novel anthelmintic candidates using deep learning is published at Int J Mol Sci. mdpi.com/3245704 #mdpiijms
Pleased to see our latest research lead by Kyle Awalt and Zi Kang Ooi @sleebslab.bsky.social @wehi-research.bsky.social on the investigation of a novel class of antimalarials that target PfATP4 published is now online at the Journal of Medicinal Chemistry. pubs.acs.org/doi/10.1021/...
Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4
To discover new antimalarials, a screen of the Janssen Jumpstarter library against Plasmodium falciparum uncovered the N-acetamide indole hit class. The structure–activity relationship of this chemoty...
pubs.acs.org
April 25, 2025 at 7:46 AM
Pleased to see our latest research lead by Kyle Awalt and Zi Kang Ooi @sleebslab.bsky.social @wehi-research.bsky.social on the investigation of a novel class of antimalarials that target PfATP4 published is now online at the Journal of Medicinal Chemistry. pubs.acs.org/doi/10.1021/...