Nikolai Slavov
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slavov-n.bsky.social
Nikolai Slavov
@slavov-n.bsky.social
Mentor, scientist & engineer. Having fun in @slavovlab.bsky.social and Parallel Squared Technology Institute @parallelsq.bsky.social with biology & single-cell proteomics.

https://nikolai.slavovlab.net
Where is the dislike button ?
November 19, 2025 at 2:00 PM
Plans use the air spaces between its cells to scatter light, modifying the path of light passing through its tissues. This creates a light gradient that helps seedlings determine where light is coming from.

quantamagazine.org/plants-find-... via
@quantamagazine.bsky.social
Plants Find Light Using Gaps Between Their Cells | Quanta Magazine
A mutant seedling revealed how plant tissues scatter incoming light, allowing plants to sense its direction and move toward it.
quantamagazine.org
November 16, 2025 at 12:34 PM
How much protein do you really need?

What the studies indicate.

nature.com/articles/d41...
How much protein do you really need? What the science says
Fitness influencers promote super-high-protein diets, but studies show there’s only so much the body can use.
nature.com
November 15, 2025 at 4:21 PM
Why the simplest explanation isn’t always the best

4/n

www.pnas.org/doi/10.1073/...
Why the simplest explanation isn’t always the best | PNAS
Why the simplest explanation isn’t always the best
www.pnas.org
November 14, 2025 at 12:45 PM
Sometimes, on simple way of describing the complexity of the data exists, at least not one that humans can readily interpret.

Then, faithfully representing the data is at odds with finding simple explanations.

“𝐸𝑣𝑒𝑟𝑦𝑡ℎ𝑖𝑛𝑔 𝑠ℎ𝑜𝑢𝑙𝑑 𝑏𝑒 𝑚𝑎𝑑𝑒 𝑎𝑠 𝑠𝑖𝑚𝑝𝑙𝑒 𝑎𝑠 𝑝𝑜𝑠𝑠𝑖𝑏𝑙𝑒, 𝑏𝑢𝑡 𝑛𝑜 𝑠𝑖𝑚𝑝𝑙𝑒𝑟”

3/n
November 14, 2025 at 12:45 PM
A basic intro with some strategies how to avoid mistakes when using dimensionality reduction.

2/n

youtu.be/nIB-WjWzDSc?...
Introduction to dimensionality reduction | Statistics for proteomics
YouTube video by Nikolai Slavov
youtu.be
November 14, 2025 at 12:45 PM
Even when the overall correlation is positive, many functional sets of proteins exhibit distinct regulation.
November 12, 2025 at 12:53 PM
Crowding more proteins per cytoplasm unit volume would hamper processes such as diffusion, which is already about ten fold slower inside the cell than in pure water.

Source: book.bionumbers.org/what-is-the-...
» What is the macromolecular composition of the cell?Cell Biology by the Numbers
Vignettes that reveal how numbers serve as a sixth sense to understanding our cells
book.bionumbers.org
November 10, 2025 at 12:57 PM
Large models are difficult to evaluate.
Fundamentally difficult.

This difficulty is not well communicated in enthusiastic social media posts advertising predictive performance.

2/2

open.substack.com/pub/gmdbioin...
November 9, 2025 at 4:11 PM
For centuries, scientific research has been a global international collaboration.

It is usually disproportionately advanced by the scientists working in the wealthiest countries and benefits the world.
November 8, 2025 at 1:35 PM