Simon J. G., PhD
@sjg-phd.bsky.social
Neuroscientist. From sleep to neural dynamics.
Previously @Columbia (‘20)
Views are my own.
Previously @Columbia (‘20)
Views are my own.
Could subtle changes in #sleep patterns indicate #ALS long before symptoms manifest? In presymptomatic carriers and early patients, #EEG revealed early & brain-wide loss of microarchitectural oscillations, linked to memory and cognitive decline (@jci.org).
doi.org/10.1172/JCI1...
doi.org/10.1172/JCI1...
JCI -
Early brain-wide disruption of sleep microarchitecture in Amyotrophic Lateral Sclerosis
doi.org
November 7, 2025 at 11:14 AM
Could subtle changes in #sleep patterns indicate #ALS long before symptoms manifest? In presymptomatic carriers and early patients, #EEG revealed early & brain-wide loss of microarchitectural oscillations, linked to memory and cognitive decline (@jci.org).
doi.org/10.1172/JCI1...
doi.org/10.1172/JCI1...
#Sleep alteration is a prominent feature of both #ageing and #neurodegeneration; but are they mechanistically distinct? Our latest review explores converging mechanisms and their translational relevance in #Alzheimer, #Parkinson, #Huntington, #ALS and #FTD and ageing.
doi.org/10.1111/jne....
doi.org/10.1111/jne....
<em>Journal of Neuroendocrinology</em> | BSN Journal | Wiley Online Library
Sleep and circadian rest-activity rhythm alterations are recognised as inherent clinical features of various neurodegenerative diseases. Traditionally viewed as secondary manifestations of neurodegen...
doi.org
September 8, 2025 at 10:11 AM
#Sleep alteration is a prominent feature of both #ageing and #neurodegeneration; but are they mechanistically distinct? Our latest review explores converging mechanisms and their translational relevance in #Alzheimer, #Parkinson, #Huntington, #ALS and #FTD and ageing.
doi.org/10.1111/jne....
doi.org/10.1111/jne....
Excited to present our first paper on #sleep in #ALS in Science Translation Medicine, which highlights early-onset alterations in patients that are suggested to occur before #motor symptoms.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Early-onset sleep alterations found in patients with amyotrophic lateral sclerosis are ameliorated by orexin antagonist in mouse models
In amyotrophic lateral sclerosis, sleep defects occur in patients, risk gene carriers, and mouse models in which they are rescued preclinically by an orexin antagonist.
www.science.org
January 29, 2025 at 8:01 PM
Excited to present our first paper on #sleep in #ALS in Science Translation Medicine, which highlights early-onset alterations in patients that are suggested to occur before #motor symptoms.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...