Spatialproteomics - an interoperable toolbox for analyzing highly multiplexed fluorescence image data https://www.biorxiv.org/content/10.1101/2025.04.29.651202v1

Happy to share the latest story from @arnaudkr.bsky.social's lab @embl.org! With @guidobarzaghi.bsky.social, we used Single Molecule Footprinting to quantify how often chromatin is accessible at enhancers after TF and chromatin environment changes! Check our preprint bit.ly/3XQMFxN + thread ⬇️ 1/11

We have known for a long time that CRISPR works - gene editing - “traditional” indel inducing, base editing and funkier types. We have a set of traits in a set of organisms where we know causal genes or alleles, and the consequences of knockouts.

Histone modifications occur independently of transcription

RNA polymerase II coordinates histone deacetylation at active promoters | Science Advances

#chromatin #transcription #generegulation

www.science.org/doi/10.1126/...