Simon Holzinger
@simholzinger.bsky.social
PostDoc Microbiome | Immunotherapy @ Poeck Lab - University Clinic Regensburg
Bioinformatician @ NGScore - Leibniz Institute for Immunotherapy
Former Chromatin Biology @ LängstLab - University of Regensburg
Bioinformatician @ NGScore - Leibniz Institute for Immunotherapy
Former Chromatin Biology @ LängstLab - University of Regensburg
6/ Huge thanks to our amazing collaborators & supporters! 🎉 @llinaslab.bsky.social @meissnerlab.bsky.social
Matthias Marti Lab @ UZH and Gernot Laengst Lab @ @uniregensburg.bsky.social
Read the full paper here: www.nature.com/articles/s41...
Matthias Marti Lab @ UZH and Gernot Laengst Lab @ @uniregensburg.bsky.social
Read the full paper here: www.nature.com/articles/s41...
Plasmodium blood stage development requires the chromatin remodeller Snf2L - Nature
Plasmodium falciparum Snf2L is an ISWI-related ATPase that actively repositions P. falciparum nucleosomes in vivo.
www.nature.com
February 20, 2025 at 9:09 AM
6/ Huge thanks to our amazing collaborators & supporters! 🎉 @llinaslab.bsky.social @meissnerlab.bsky.social
Matthias Marti Lab @ UZH and Gernot Laengst Lab @ @uniregensburg.bsky.social
Read the full paper here: www.nature.com/articles/s41...
Matthias Marti Lab @ UZH and Gernot Laengst Lab @ @uniregensburg.bsky.social
Read the full paper here: www.nature.com/articles/s41...
5/ This work highlights the potential of chromatin remodeling-targeted therapies for malaria and other parasites and also sheds light on the role of chromatin regulation in Plasmodium biology.
February 20, 2025 at 9:09 AM
5/ This work highlights the potential of chromatin remodeling-targeted therapies for malaria and other parasites and also sheds light on the role of chromatin regulation in Plasmodium biology.
4/ Given the evolutionary distance between Plasmodium and human chromatin remodelers, she also explored the drugability of PfSNF2L finding a Plasmodium-specific inhibitor that mimics PfSNF2L Knockout!
February 20, 2025 at 9:09 AM
4/ Given the evolutionary distance between Plasmodium and human chromatin remodelers, she also explored the drugability of PfSNF2L finding a Plasmodium-specific inhibitor that mimics PfSNF2L Knockout!
3/ She shows that PfSNF2L is required for the correct timing of the entire transcriptional program, making it essential in asexual development and sexual differentiation of the parasite.
February 20, 2025 at 9:09 AM
3/ She shows that PfSNF2L is required for the correct timing of the entire transcriptional program, making it essential in asexual development and sexual differentiation of the parasite.
2/ Fantastic work by Maresa characterizing the Plasmodium chromatin remodeler PfSNF2L both in vitro and in vivo and also finding an inhibitor with great potential as a drug!
February 20, 2025 at 9:09 AM
2/ Fantastic work by Maresa characterizing the Plasmodium chromatin remodeler PfSNF2L both in vitro and in vivo and also finding an inhibitor with great potential as a drug!