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Signa Vitae
@signavitaejournal.bsky.social
Where science meets critical care.
Anesthesia | ICU | Emergency | Pain Medicine
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🚨New horizons in resuscitation!

ECMO is revolutionizing non-traumatic critical care

From cardiac arrest to ARDS and poisoning, this review explores expanding indications, techniques, and outcomes

🔗 doi.org/10.22514/sv....

#ECMO #ECPR #CriticalCare #Resuscitation #SignaVitae
November 13, 2025 at 12:57 PM
🩸🚑 Low pulse pressure sharply boosts mortality risk in trauma, especially at SBP extremes

New model reveals a bimodal mortality pattern and a sharp risk rise with low PP in early trauma care

🔗 doi.org/10.22514/sv....

#Trauma #CriticalCare #EmergencyMedicine #Hemodynamics
November 11, 2025 at 12:58 PM
Emergence delirium remains a challenge after pediatric tonsillectomy
This RCT reports an 80% reduction with peritonsillar bupivacaine infiltration suggesting pain control may hold the key
How would this influence your PACU practice?
🔗 doi.org/10.22514/sv.2025.144
#Anesthesia #PainMedicine #Delirium
October 31, 2025 at 12:58 PM
🚨 New model to predict sepsis-associated DIC!

Using MIMIC-IV data, researchers built a tool combining inflammation, coagulation & RBC markers (SOFA, INR, RDW…)

📈 AUC 0.78, better than single indicators
Early detection saves lives

🔗 doi.org/10.22514/sv....

#Sepsis #LLM #AI #CriticalCare
October 29, 2025 at 1:07 PM
🧠 Tormentic acid shows potent neuroprotection in stroke models reducing microglia-driven inflammation and blocking NF-κB activation

A natural compound with therapeutic promise for ischemia-reperfusion injury

👉 doi.org/10.22514/sv....

#Neuroprotection #Stroke #criticalcare
October 24, 2025 at 12:10 PM
🧬A new protocol for metabolomics and cytokine profiling could transform how we understand and treat #ARDS

Standardized multi-omic analysis enables precise phenotyping and opens the door to truly personalized critical care

doi.org/10.22514/sv....

#CriticalCare #Metabolomics #ICU #FOAMed #meded
October 17, 2025 at 11:58 AM
🩺A year of impact in #CriticalCare!

From groundbreaking sepsis insights to #AI saving lives in the #EmergencyDepartment explore the top Signa Vitae papers of 2024, redefining how we care for the critically ill

🔗 doi.org/10.22514/sv....

#ICU #Sepsis #Anesthesia #FOAMed #Meded
October 15, 2025 at 12:13 PM
💨 Every breath in the OR has a climate cost

💤Anesthetic gasses can warm the planet up to 2,500× more than CO₂!

📚This new review calls for a green revolution in anesthesia low-flow, TIVA, and regional techniques can slash emissions by >80%

🔗 doi.org/10.22514/sv....
October 8, 2025 at 11:57 AM
🧪Elevated LHR, SIRI, and SII values at ICU admission independently predict hyperactive delirium

🔥Simple inflammatory biomarkers may enable early risk stratification and improve patient outcomes

🔗 doi.org/10.22514/sv.2025.133

#CriticalCare #delirium #Biomarkers #inflammation #ICU #FOAMed #MedEd
October 6, 2025 at 12:18 PM
🥑Can diet protect the heart?

A multicenter study finds omega-3 intake cuts sudden cardiac arrest risk in men by 50%, but not in women

♂️♀️Sex-specific differences may guide tailored prevention.

🔗 doi.org/10.22514/sv.2025.128

#cardiacarrest #diet #cardiology #FOAMed
October 2, 2025 at 11:53 AM
🧒In pediatric trauma, the lactate-to-albumin ratio (LAR) strongly predicts mortality

🧪Early measurement can identify high-risk patients and guide life saving decisions in the PICU

🔗 doi.org/10.22514/sv....

#Pediatrics #peds #TraumaCare #CriticalCare#ICU #FOAMed #Meded
September 30, 2025 at 12:03 PM
👁️ New in Signa Vitae: CT-measured optic nerve sheath diameter (ONSD) helps spot methanol intoxication & predict outcomes

Cut-off 5.57 mm → 85% sens., 80% spec.

🚑A potential game changer in the ED

🔗 doi.org/10.22514/sv.2025.129

#EmergencyMedicine #Toxicology #CriticalCare
September 25, 2025 at 12:17 PM
💔 In intensive care, every line counts.

👶 1 in 3 central venous catheters in critically ill children are misplaced — risking complications when they’re most vulnerable.

✨ Smarter placement could save young lives.

🔗 doi.org/10.22514/sv....

#PICU #Pediatrics #PatientSafety
September 22, 2025 at 12:00 PM
📊 Our retrospective study finds no difference in hemodynamic stability between low-flow sevoflurane and desflurane during laparoscopic sleeve gastrectomy

Evidence supports low-flow anesthesia as safe & feasible in obese patients

🔗 www.signavitae.com/articles/10.22514/sv.2025
September 17, 2025 at 11:58 AM
🌀 After the 2023 Türkiye earthquakes, cases of scabies & other itchy skin diseases surged in overcrowded shelters

🧼Better hygiene, clean water & safer housing are vital to protect survivors

🔗 doi.org/10.22514/sv....

#Earthquake #Health #dermatology #Turkiye #Hygiene
September 15, 2025 at 12:05 PM
🤖Can AI help doctors read and interpret blood tests?

A new study shows #ChatGPT can interpret arterial blood gases as well as physicians

💡This could lighten workloads and support faster, safer care in the ICU

🔗 doi.org/10.22514/sv.2025.138

#Healthcare #AI #FutureOfMedicine #MedEd
September 12, 2025 at 11:37 AM
🌍💉 Should anesthetic gases like desflurane really be banned for their climate impact?

This new editorial argues that their effect on global temperature is negligible & reversible raising questions about science vs policy in medicine

🔗 doi.org/10.22514/sv....

#Climatechange
September 10, 2025 at 12:30 PM
🚑 Rapid sequence intubation is a lifesaving procedure but hypoxemia during intubation can be deadly

❓Can HFNC make intubation safer?

A new review explores how this technique could help patients at risk of hypoxemia

🔗 doi.org/10.22514/sv....

#Criticalcare #anesthesia #icu #emergenymeddicine
September 8, 2025 at 12:24 PM
😷 Feeling “just weak” or “tired” can land many older adults in the ER.
But these non-specific complaints don’t always mean worse outcomes.
Our study across 8 hospitals shows they often stay longer in the ED—but need ICU less often than those with clear symptoms.

🔗 doi.org/10.22514/sv....

#elderly
September 5, 2025 at 12:00 PM
In the September issue of SIGNA VITAE there will be 4 articles on volatile anesthesia!

Two of them on the global warming potentials debate

Stay tuned on www.signavitae.com and on your favorite social media

#climatechange #globalwarming #anesthesia #volatile #emergency
September 1, 2025 at 11:50 AM
🧠 Pediatric stroke is rare but devastating
This case links Epstein-Barr virus to focal cerebral arteriopathy, urging clinicians to consider viral triggers in acute pediatric neurologic events
⏱ Early imaging Full recovery
www.signavitae.com/articles/10.22514/sv.2025.119
#Neurology #EmergencyMedicine
August 29, 2025 at 9:55 AM
This study shows gastric ultrasound correlates well with residual volume even across different feeding protocols

✅ Less interruption ✅ More patient comfort

Ultrasound might just be the new standard in ICU nutritional monitoring

🔗www.signavitae.com/articles/10.22514/sv.2025.111

#CriticalCare #ICU
August 25, 2025 at 12:22 PM
🫁 Life after steroids?

This real-world study shows rapid improvement in asthma control and quality of life after starting benralizumab — even in patients with comorbidities.

The message is clear: the biologic era in severe asthma is here to stay

🔗 www.signavitae.com/articles/10....
August 19, 2025 at 12:52 PM
🧠POD is a surgeon’s nightmare. But can better pain control help?

💊This RCT finds that while oxycodone didn’t reduce delirium compared to sufentanil, it did improve pain scores and reduced side effects

🔗www.signavitae.com/articles/10.22514/sv.2025.108

#Delirium #PostOpCare #Anesthesia #MedEd
August 16, 2025 at 11:31 AM
🫁Too deep too shallow both dangerous

🧒Intubating a child is not just about skill it’s about precision

This review maps the latest evidence on how to get it right, from formulas to ultrasound to palpation

#pediatric #anesthesia #pedsanes

🔗 www.signavitae.com/articles/10.22514/sv.2025.120
August 14, 2025 at 12:04 PM