Paul Sigala
@sigalalab.bsky.social
biochemist, parasitologist, mentor, student
https://sigala.biochem.utah.edu
https://sigala.biochem.utah.edu
@uofuhealth.bsky.social put out a gracious highlight on our manuscript @pnas.org #malaria @uofubiochem.bsky.social @uofutahcihd.bsky.social
healthcare.utah.edu/newsroom/new...
healthcare.utah.edu/newsroom/new...
Malaria Parasites are Full of Wildly Spinning Iron Crystals. Scientists Finally Know Why.
The first known metallic nanomotor in biology is powered by rocket fuel.
healthcare.utah.edu
October 29, 2025 at 12:37 AM
@uofuhealth.bsky.social put out a gracious highlight on our manuscript @pnas.org #malaria @uofubiochem.bsky.social @uofutahcihd.bsky.social
healthcare.utah.edu/newsroom/new...
healthcare.utah.edu/newsroom/new...
Thrilled our study on heme crystal motion in #malaria @parasitesrule.org is now published @pnas.org, support from NIH, @bwfund.bsky.social, @uofutahcihd.bsky.social, UofU 3i. With Fu and Bidone labs @price.utah.edu, @uofubiochem.bsky.social, @uofuhealth.bsky.social
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Chemical propulsion of hemozoin crystal motion in malaria parasites | PNAS
Malaria parasites infect red blood cells where they digest host hemoglobin and release
free heme inside a lysosome-like organelle called the food v...
www.pnas.org
October 28, 2025 at 7:55 PM
Thrilled our study on heme crystal motion in #malaria @parasitesrule.org is now published @pnas.org, support from NIH, @bwfund.bsky.social, @uofutahcihd.bsky.social, UofU 3i. With Fu and Bidone labs @price.utah.edu, @uofubiochem.bsky.social, @uofuhealth.bsky.social
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
It was a pleasure to host these speakers for our 2025 #Postdoc Rising Stars event! Great science and terrific symposium. @uofubiochem.bsky.social @uuhsresearch.bsky.social
October 3, 2025 at 7:37 PM
It was a pleasure to host these speakers for our 2025 #Postdoc Rising Stars event! Great science and terrific symposium. @uofubiochem.bsky.social @uuhsresearch.bsky.social
Very excited to welcome these #postdoc speakers to our annual @utah.edu Rising Stars Symposium cohosted by @uofubiochem.bsky.social and Med Chem @uuhsresearch.bsky.social with keynote address by Ryan Watts at Denali
October 1, 2025 at 7:30 PM
Very excited to welcome these #postdoc speakers to our annual @utah.edu Rising Stars Symposium cohosted by @uofubiochem.bsky.social and Med Chem @uuhsresearch.bsky.social with keynote address by Ryan Watts at Denali
We're thrilled to announce the 2025 Postdoctoral Rising Stars Symposium cohosted @uofuhealth.bsky.social by @uofubiochem.bsky.social and MedChem with keynote by Ryan Watts at Denali Therapeutics
September 10, 2025 at 6:35 PM
We're thrilled to announce the 2025 Postdoctoral Rising Stars Symposium cohosted @uofuhealth.bsky.social by @uofubiochem.bsky.social and MedChem with keynote by Ryan Watts at Denali Therapeutics
Congratulations to lab members Aldo García-Guerrero and Erica Hastings for winning the @uofubiochem.bsky.social Evelyn Bruenger and Marjorie Riches Gunn Awards for Postdoctoral and Graduate Student Research Excellence, respectively! #malaria @uofutahcihd.bsky.social @uuhsresearch.bsky.social
June 18, 2025 at 5:23 PM
Congratulations to lab members Aldo García-Guerrero and Erica Hastings for winning the @uofubiochem.bsky.social Evelyn Bruenger and Marjorie Riches Gunn Awards for Postdoctoral and Graduate Student Research Excellence, respectively! #malaria @uofutahcihd.bsky.social @uuhsresearch.bsky.social
Happening today! @uofubiochem.bsky.social @uofutahcihd.bsky.social @parasitesrule.org #malaria #biophysics
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
May 15, 2025 at 2:03 PM
Reposted by Paul Sigala
Congrats to our chair, Wes Sundquist, on being awarded the Bhaumik Breakthrough of the Year Award for work on lenacapavir!
Yvette Raphael, Gilead Sciences—with special recognition of Moupali Das—and Wesley Sundquist have been awarded the Mani L. Bhaumik Breakthrough of the Year Award for their work on HIV drug lenacapavir. www.aaas.org/news/road-le...
May 8, 2025 at 7:45 PM
Congrats to our chair, Wes Sundquist, on being awarded the Bhaumik Breakthrough of the Year Award for work on lenacapavir!
It's an honor to announce the upcoming PhD thesis defense of Erica Hastings, who will present her work on #malaria parasites and the biophysics of hemozoin motion @uofubiochem.bsky.social ky.social @uofutahcihd.bsky.social
@parasitesrule.org
@parasitesrule.org
April 28, 2025 at 10:01 PM
It's an honor to announce the upcoming PhD thesis defense of Erica Hastings, who will present her work on #malaria parasites and the biophysics of hemozoin motion @uofubiochem.bsky.social ky.social @uofutahcihd.bsky.social
@parasitesrule.org
@parasitesrule.org
Thrilled to announce a new collaborative preprint from PhD student Erica Hastings unraveling the nature and mechanism of fascinating hemozoin crystal motion inside #malaria parasites @uofubiochem.bsky.social @uofutahcihd.bsky.social @bwfund.bsky.social
@parasitesrule.org
t.co/zLPgIS1rig
@parasitesrule.org
t.co/zLPgIS1rig
https://www.biorxiv.org/content/10.1101/2025.04.25.650681v1
t.co
April 28, 2025 at 3:25 PM
Thrilled to announce a new collaborative preprint from PhD student Erica Hastings unraveling the nature and mechanism of fascinating hemozoin crystal motion inside #malaria parasites @uofubiochem.bsky.social @uofutahcihd.bsky.social @bwfund.bsky.social
@parasitesrule.org
t.co/zLPgIS1rig
@parasitesrule.org
t.co/zLPgIS1rig
Thanks to @pubs.acs.org for featuring our work on cyt c biogenesis in #malaria parasites on the front cover!
@uofubiochem.bsky.social @uofutahcihd.bsky.social pubs.acs.org/doi/10.1021/...
@uofubiochem.bsky.social @uofutahcihd.bsky.social pubs.acs.org/doi/10.1021/...
ACS Infectious Diseases
Predicted structure of the key complex from malaria parasites that attaches heme to mitochondrial cytochrome c to support the critical function of the electron transport chain. This structure was predicted using the AlphaFold 3 server and rendered using PyMOL. View the article.
pubs.acs.org
April 11, 2025 at 4:20 PM
Thanks to @pubs.acs.org for featuring our work on cyt c biogenesis in #malaria parasites on the front cover!
@uofubiochem.bsky.social @uofutahcihd.bsky.social pubs.acs.org/doi/10.1021/...
@uofubiochem.bsky.social @uofutahcihd.bsky.social pubs.acs.org/doi/10.1021/...
Very proud of PhD student Erica Hastings who gave a talk and poster at the American Physical Society meeting on collaborative work to understand hemozoin crystal motion in #malaria parasites @uofubiochem.bsky.social @uofutahcihd.bsky.social @bwfund.bsky.social Paper coming soon!
March 21, 2025 at 6:09 PM
Very proud of PhD student Erica Hastings who gave a talk and poster at the American Physical Society meeting on collaborative work to understand hemozoin crystal motion in #malaria parasites @uofubiochem.bsky.social @uofutahcihd.bsky.social @bwfund.bsky.social Paper coming soon!