@sidoniaf.bsky.social
Reposted
AID, happy 25th: www.sciencedirect.com/science/arti...
Activation-induced cytidine deaminase: The missing piece of many puzzles
Twenty-five years ago, two Cell papers reported the key missing functional piece in three molecular puzzles. The genetic swapping of immunoglobulin co…
www.sciencedirect.com
December 11, 2025 at 2:04 PM
AID, happy 25th: www.sciencedirect.com/science/arti...
Reposted
This #Preprint reports that B6 (but not wild mice) have a truncated PDL2, missing an active intracellular signalling domain:
"Surprisingly, in C57BL/6J (B6) mice PD-L2 has only a 5-amino acid intracellular domain, and the same is true for several other laboratory mouse strains"
#Immunology
"Surprisingly, in C57BL/6J (B6) mice PD-L2 has only a 5-amino acid intracellular domain, and the same is true for several other laboratory mouse strains"
#Immunology
PD-L2 Regulates Natural Antibody and IL-10 Secretion by B-1 cells
B-1 cells are innate-like lymphocytes that play a critical role in homeostasis by secreting natural antibodies, typically IgM, and immunosuppressive molecules such as IL-10. However, the regulation of...
www.biorxiv.org
December 15, 2025 at 6:03 AM
This #Preprint reports that B6 (but not wild mice) have a truncated PDL2, missing an active intracellular signalling domain:
"Surprisingly, in C57BL/6J (B6) mice PD-L2 has only a 5-amino acid intracellular domain, and the same is true for several other laboratory mouse strains"
#Immunology
"Surprisingly, in C57BL/6J (B6) mice PD-L2 has only a 5-amino acid intracellular domain, and the same is true for several other laboratory mouse strains"
#Immunology
Reposted
In a @cp-cell.bsky.social Benchmarks article, Masamichi Muramatsu, Sidonia Fagarasan et al tell the story of the discovery of AID in the Honjo lab, solving the decades long mystery of the molecular effector of Ig class switch recombination and somatic hypermutation.
#Immunology
#Immunology
Activation-induced cytidine deaminase: The missing piece of many puzzles
Twenty-five years ago, two Cell papers reported the key missing functional piece in
three molecular puzzles. The genetic swapping of immunoglobulin constant regions,
the mutational fine-tuning of anti...
www.cell.com
December 15, 2025 at 6:07 AM
In a @cp-cell.bsky.social Benchmarks article, Masamichi Muramatsu, Sidonia Fagarasan et al tell the story of the discovery of AID in the Honjo lab, solving the decades long mystery of the molecular effector of Ig class switch recombination and somatic hypermutation.
#Immunology
#Immunology
Reposted
Muramatsu had previously reported the discovery of the AID gene in a screen. In the 2000 Cell paper, he and his collaborators in the Honjo lab, including Fagarasan demonstrated its function in mice.
www.cell.com/AJHG/fulltex...
www.cell.com/AJHG/fulltex...
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
Induced overexpression of AID in CH12F3-2 B lymphoma cells augmented class switching
from IgM to IgA without cytokine stimulation. AID deficiency caused a complete defect
in class switching and showed...
www.cell.com
December 15, 2025 at 6:10 AM
Muramatsu had previously reported the discovery of the AID gene in a screen. In the 2000 Cell paper, he and his collaborators in the Honjo lab, including Fagarasan demonstrated its function in mice.
www.cell.com/AJHG/fulltex...
www.cell.com/AJHG/fulltex...
Reposted
In the same issue, Revy, Fischer and Durandy showed that the same gene, AID, was responsible for a mysterious form of hyper-IgM syndrome that was not linked to mutations in the CD40 pathway, demonstrating that AID also controlled CSR and SHM in humans.
www.cell.com/fulltext/S00...
www.cell.com/fulltext/S00...
Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)
The activation-induced cytidine deaminase (AID) gene, specifically expressed in germinal
center B cells in mice, is a member of the cytidine deaminase family. We herein report
mutations in the human c...
www.cell.com
December 15, 2025 at 6:12 AM
In the same issue, Revy, Fischer and Durandy showed that the same gene, AID, was responsible for a mysterious form of hyper-IgM syndrome that was not linked to mutations in the CD40 pathway, demonstrating that AID also controlled CSR and SHM in humans.
www.cell.com/fulltext/S00...
www.cell.com/fulltext/S00...
Reposted
Prof Tasuku Honjo is now the Director of CCII, our new center in Kyoto University, dedicated to deciphering anti-tumor immunity and discovering the next generation of cancer immunotherapies.
www.ccii.med.kyoto-u.ac.jp/en/
www.ccii.med.kyoto-u.ac.jp/en/
December 15, 2025 at 6:14 AM
Prof Tasuku Honjo is now the Director of CCII, our new center in Kyoto University, dedicated to deciphering anti-tumor immunity and discovering the next generation of cancer immunotherapies.
www.ccii.med.kyoto-u.ac.jp/en/
www.ccii.med.kyoto-u.ac.jp/en/
Reposted
Participants emerge from the conference room into the bright sunlight of Naoshima Island in CCII's first international symposium on Cancer, Metabolism, and Immunity.
CCII sponsored this small, intimate meeting where participants freely shared and discussed ideas & data in a beautiful setting.
CCII sponsored this small, intimate meeting where participants freely shared and discussed ideas & data in a beautiful setting.
December 16, 2025 at 6:16 AM
Participants emerge from the conference room into the bright sunlight of Naoshima Island in CCII's first international symposium on Cancer, Metabolism, and Immunity.
CCII sponsored this small, intimate meeting where participants freely shared and discussed ideas & data in a beautiful setting.
CCII sponsored this small, intimate meeting where participants freely shared and discussed ideas & data in a beautiful setting.