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shouyafeng.bsky.social
@shouyafeng.bsky.social
15 followers 23 following 1 posts
Masters Lab Postdoc at Hudson Institute of Medical Research
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sethlucianmasters.bsky.social
A large dataset we hope is helpful for patients who may have CAPS, an #autoinflammatory condition associated with genetic variants in NLRP3. Lots of "variants of uncertain significance" now have a specific readout from our in vitro assay which can help with clinical diagnosis.
rdcu.be/d9iRG
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants
Nature Immunology - Gain-of-function variants in the gene encoding NLRP3 lead to constitutive inflammasome activation and excessive IL-1β production. In this resource, authors perform...
rdcu.be
February 11, 2025 at 9:57 AM
shouyafeng.bsky.social
Thrilled to share that our paper is now online in Nature Immunology! Huge thanks to all the amazing lab members and collaborators who made this possible. Science is a team effort, and I’m grateful to be working with such a fantastic group. #MastersLab#inflammasomes

www.nature.com/articles/s41...
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants - Nature Immunology
Gain-of-function variants in the gene encoding NLRP3 lead to constitutive inflammasome activation and excessive IL-1β production. In this resource, authors perform functional screening of clinically r...
www.nature.com
February 11, 2025 at 9:30 AM