Shiliang Tian
@shiliangtian.bsky.social
Assistant Professor at Purdue University | Exploring metalloproteins in human iron/copper homeostasis | Structural and spectroscopic studies of cobalamin-dependent mutases
Reposted by Shiliang Tian
New research in Science represents a notable step forward in designing enzymes from scratch.
With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins. scim.ag/41kZBOI
With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins. scim.ag/41kZBOI
Computational design of serine hydrolases
The design of enzymes with complex active sites that mediate multistep reactions remains an outstanding challenge. With serine hydrolases as a model system, we combined the generative capabilities of ...
scim.ag
February 18, 2025 at 3:08 PM
New research in Science represents a notable step forward in designing enzymes from scratch.
With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins. scim.ag/41kZBOI
With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins. scim.ag/41kZBOI
Reposted by Shiliang Tian
For #BlackHistoryMonth, read about modern-day Black chemists making history: C&EN's 2021 Trailblazers issue, curated by guest editor Paula Hammond, celebrates Black chemists and chemical engineers.
#BlackinChem cen.acs.org/careers/dive...
#BlackinChem cen.acs.org/careers/dive...
Trailblazers 2021: We have been here all along
Guest editor Paula Hammond, MIT drug delivery pioneer, describes her vision for this special issue of C&EN celebrating Black Trailblazers in chemistry and chemical engineering
cen.acs.org
February 18, 2025 at 3:46 PM
For #BlackHistoryMonth, read about modern-day Black chemists making history: C&EN's 2021 Trailblazers issue, curated by guest editor Paula Hammond, celebrates Black chemists and chemical engineers.
#BlackinChem cen.acs.org/careers/dive...
#BlackinChem cen.acs.org/careers/dive...
Reposted by Shiliang Tian
First post on Blue sky! Congratulations to graduate student Yorick Chiang and scientist Masa Ohashi on discovery of new copper dependent halogen from Nature @nature.com !
Many thanks to the wonderful collaborators!
www.nature.com/articles/s41...
Many thanks to the wonderful collaborators!
www.nature.com/articles/s41...
Copper-dependent halogenase catalyses unactivated C−H bond functionalization - Nature
A halogenase enzyme uses the copper in its active site to catalyse iterative chlorinations on multiple unactivated carbon−hydrogen bonds, enabling carbon−hydrogen functionalization that is not achieva...
www.nature.com
January 29, 2025 at 5:34 PM
First post on Blue sky! Congratulations to graduate student Yorick Chiang and scientist Masa Ohashi on discovery of new copper dependent halogen from Nature @nature.com !
Many thanks to the wonderful collaborators!
www.nature.com/articles/s41...
Many thanks to the wonderful collaborators!
www.nature.com/articles/s41...