Ian Shih
@shihyyi.bsky.social
Brain imager, Professor and Vice Chair for Research at UNC Neurology; Associate Director UNC Biomedical Research Imaging Center; Director, UNC Center for Animal MRI (http://camri.org/)
12/ SORDINO for imaging glymphatic dynamics💧: Using Gd contrast, SORDINO enables brain-wide tracking of CSF influx without susceptibility artifacts. Its silent acquisition paves the way for studying glymphatic function in awake and sleeping mice – providing insights into brain waste clearance!
March 17, 2025 at 4:17 PM
12/ SORDINO for imaging glymphatic dynamics💧: Using Gd contrast, SORDINO enables brain-wide tracking of CSF influx without susceptibility artifacts. Its silent acquisition paves the way for studying glymphatic function in awake and sleeping mice – providing insights into brain waste clearance!
11/ SORDINO for cross-brain coupling during social behavior 🐭🐭: We developed a dual-mouse hyperscanning platform, enabling simultaneous fMRI of two interacting mice. SORDINO reveals synchronized inter-brain activity in DMN & SN, uncovering neural dynamics of social interactions!
March 17, 2025 at 4:17 PM
11/ SORDINO for cross-brain coupling during social behavior 🐭🐭: We developed a dual-mouse hyperscanning platform, enabling simultaneous fMRI of two interacting mice. SORDINO reveals synchronized inter-brain activity in DMN & SN, uncovering neural dynamics of social interactions!
10/ SORDINO maps skilled motor actions in mice🤏: We designed a food pellet delivery system and trained mice to reach and grasp during fMRI. SORDINO captures brain-wide motor sequence activity, initiated and executed by the subjects – pushing the frontiers of naturalistic fMRI!
March 17, 2025 at 4:14 PM
10/ SORDINO maps skilled motor actions in mice🤏: We designed a food pellet delivery system and trained mice to reach and grasp during fMRI. SORDINO captures brain-wide motor sequence activity, initiated and executed by the subjects – pushing the frontiers of naturalistic fMRI!
6/ SORDINO minimizes artifacts👻: Drastically reduced ghosting, distortion, susceptibility & motion artifacts. Unlike EPI, SORDINO preserves signal integrity in 🧲challenging regions and maintains signal stability during passive limb movement.
March 17, 2025 at 4:11 PM
6/ SORDINO minimizes artifacts👻: Drastically reduced ghosting, distortion, susceptibility & motion artifacts. Unlike EPI, SORDINO preserves signal integrity in 🧲challenging regions and maintains signal stability during passive limb movement.
5/ SORDINO enables simultaneous miniscope calcium imaging🔬: SORDINO’s minimal interference allows for real-time calcium imaging at cellular resolution using a head-mounted miniscope in MRI. This provides new possibilities for multimodal neuroimaging across spatiotemporal scales.
March 17, 2025 at 4:10 PM
5/ SORDINO enables simultaneous miniscope calcium imaging🔬: SORDINO’s minimal interference allows for real-time calcium imaging at cellular resolution using a head-mounted miniscope in MRI. This provides new possibilities for multimodal neuroimaging across spatiotemporal scales.
2/ We named SORDINO (Steady-state On-the-Ramp Detection of INduction-decay with Oversampling) after the 🎶musical term for muting. It keeps gradient amplitudes constant while smoothly changing direction, eliminating acoustic noise & artifacts while maximizing sensitivity.
March 17, 2025 at 3:51 PM
2/ We named SORDINO (Steady-state On-the-Ramp Detection of INduction-decay with Oversampling) after the 🎶musical term for muting. It keeps gradient amplitudes constant while smoothly changing direction, eliminating acoustic noise & artifacts while maximizing sensitivity.