Here we transform the natural product into a series of partial, full and G protein biased KOR-selective agonists, which appear centrally active in vivo. Core diversification was aided by mutually chemoselective sp3-sp2 and sp2-sp2 cross-couplings.

“…deaths of such children but also to deny these deaths and call them lies. The denials erase these children and dodge all responsibility.”

“If Rubio needs further reminder of the human toll, this little girl is Achol Deng, 8, who likewise died when she lost access to antiretrovirals because of the U.S.A.I.D. freeze.”
“I share these photos of Evan and Achol because it strikes me as doubly offensive not only to cause unnecessary..”

…and it turned the tide of AIDS around the world and built enormous good will toward the US.”
“Then along came President Trump and his freeze on most humanitarian aid in January. How could a 5-year-old orphan obtain medicine on his own? Evan weakened and soon died of an opportunistic infection.”

“… five years America kept him alive with antiretroviral medicines costing less than 12 cents a day, through the President’s Emergency Plan for AIDS Relief, or PEPFAR. This was a program started by President George W. Bush that has saved more than 26 million lives so far…”

““That’s a lie,” Rubio said. “False.”

So let me help Rubio with the truth. Meet Evan Anzoo, a 5-year-old boy who was born with H.I.V. in South Sudan.”

“I mentioned Evan in a column in March from South Sudan. This was a child as precious as yours or mine.”

“Evan’s life was in our hands, and for…”

“… is whether to measure the dead in the thousands, tens of thousands or hundreds of thousands.”
“So Representative Brad Sherman, a California Democrat, challenged Rubio, citing reporting overseas by me and by Reuters of individuals who died as a result of the shutdown of American humanitarian aid.”

Here are some published studies, more en route. The pharmacology is ongoing, hence the need for continued support.
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
pubs.acs.org/doi/10.1021/...
www.science.org/doi/pdf/10.1...
www.nature.com/articles/s41...

The salvinorins and GB alkaloids are poised to become next generation medicines to treat pain and pruritis, as well as substance use disorders (SUDs) and mood disorders.

I can’t imagine a better investment of federal funds.

Or a bigger waste if the devastating cuts to NSF and NIH proceed.

Sounds like somebody is angling for a high ranking govt position.

No it won’t, but I’ll check it out anyway