Busy and exciting poster session @sppirit-network.bsky.social conference. SheinerLab's Anil and Victor spotted checking out some cool work!

Our session explored how studying bioenergetics enzymes via structural biology in divergent protist sheds light on the role of these enzymes and their assemblies across eukaryotes and on how they function in the context of each organisms’ specialised needs.

@fad1.bsky.social showing us how gene drives will end malaria!!

Some great models used to study endosymbiosis and what does it take to make a stable relationship:

Julius Lukes LOPIT of Insect Trypanosomes reveals new host-endosymbiont interactions

Ellen Yeh Epithemia diatoms probes the underlying mechanisms of establishing endosymbiosis

First - a vivid discussion about determining the origin and early evolution of eukaryotes following Andrew Roger's talk.

Other complex III inhibitors are being developed as drug leads for apicomplexan diseases.
Together with Stone Doggett and colleagues at @OHSUNewswe we showed how the drug-lead ELQ-300 binds Toxoplasma complex III and designed a more potent version.

Atovaquone is a clinically used drug for apicomplexan diseases such as #malaria and #toxoplasmosis, but its precise mechanism of inhibition was unknown.
We showed how atovaquone interacts with Toxoplasma complex III and why it is selective to apicomplexan compared to human.

Respiratory complexes form “super-complexes” whose physiological function is debated, and assembly only studied in a few organisms.
We showed that apicomplexan conserved proteins mediate III2-IV supercomplex formation, and that this provides competitive growth advantage.