Shannon Sie
@shannonsie.bsky.social
Reposted by Shannon Sie
SEPTEMBER ISSUE | Our Featured PERSPECTIVE is on "The oesophagus as an immune organ"
www.nature.com/articles/s41...
#Gastrosky
www.nature.com/articles/s41...
#Gastrosky
August 28, 2025 at 8:14 AM
SEPTEMBER ISSUE | Our Featured PERSPECTIVE is on "The oesophagus as an immune organ"
www.nature.com/articles/s41...
#Gastrosky
www.nature.com/articles/s41...
#Gastrosky
5/
I feel like the timing here could really matter for identifying therapeutic intervention windows, especially since early TNF-alpha blockade can prevent the formation of lymphoid aggregates (which likely precede TLS), but seems less effective once these structures are established.
I feel like the timing here could really matter for identifying therapeutic intervention windows, especially since early TNF-alpha blockade can prevent the formation of lymphoid aggregates (which likely precede TLS), but seems less effective once these structures are established.
June 2, 2025 at 5:40 PM
5/
I feel like the timing here could really matter for identifying therapeutic intervention windows, especially since early TNF-alpha blockade can prevent the formation of lymphoid aggregates (which likely precede TLS), but seems less effective once these structures are established.
I feel like the timing here could really matter for identifying therapeutic intervention windows, especially since early TNF-alpha blockade can prevent the formation of lymphoid aggregates (which likely precede TLS), but seems less effective once these structures are established.
4/
While it’s helpful to know that fully formed TLS are present in HS lesions, it would be valuable to clarify how early in lesion development these structures actually become fully formed — whether during the pre-exudative phase, or only once lesions progress to the exudative stage.
While it’s helpful to know that fully formed TLS are present in HS lesions, it would be valuable to clarify how early in lesion development these structures actually become fully formed — whether during the pre-exudative phase, or only once lesions progress to the exudative stage.
June 2, 2025 at 5:40 PM
4/
While it’s helpful to know that fully formed TLS are present in HS lesions, it would be valuable to clarify how early in lesion development these structures actually become fully formed — whether during the pre-exudative phase, or only once lesions progress to the exudative stage.
While it’s helpful to know that fully formed TLS are present in HS lesions, it would be valuable to clarify how early in lesion development these structures actually become fully formed — whether during the pre-exudative phase, or only once lesions progress to the exudative stage.
3/
To clarify — I’m referring to instances in general where fully formed TLSs are reported in HS lesions, including the ones cited here like Lowe et al., 2024 and Yu et al., 2024.
To clarify — I’m referring to instances in general where fully formed TLSs are reported in HS lesions, including the ones cited here like Lowe et al., 2024 and Yu et al., 2024.
June 2, 2025 at 5:40 PM
3/
To clarify — I’m referring to instances in general where fully formed TLSs are reported in HS lesions, including the ones cited here like Lowe et al., 2024 and Yu et al., 2024.
To clarify — I’m referring to instances in general where fully formed TLSs are reported in HS lesions, including the ones cited here like Lowe et al., 2024 and Yu et al., 2024.
2/
Based on their association with keratinized epithelial tunnels, it seems likely they were collected during the exudative or post-exudative phase, and most likely during Hurley Stage II or III, when tunnel formation typically occurs—but I haven’t seen this explicitly stated.
Based on their association with keratinized epithelial tunnels, it seems likely they were collected during the exudative or post-exudative phase, and most likely during Hurley Stage II or III, when tunnel formation typically occurs—but I haven’t seen this explicitly stated.
June 2, 2025 at 1:19 PM
2/
Based on their association with keratinized epithelial tunnels, it seems likely they were collected during the exudative or post-exudative phase, and most likely during Hurley Stage II or III, when tunnel formation typically occurs—but I haven’t seen this explicitly stated.
Based on their association with keratinized epithelial tunnels, it seems likely they were collected during the exudative or post-exudative phase, and most likely during Hurley Stage II or III, when tunnel formation typically occurs—but I haven’t seen this explicitly stated.
Oh, so you are at the peak of it right now. 😄 I guess every phase comes with its own mix of rhythms and surprises. In a way, the pandemic bought us the time we might otherwise have missed. It's nice that you have a pair 👫
May 20, 2025 at 3:56 AM
Oh, so you are at the peak of it right now. 😄 I guess every phase comes with its own mix of rhythms and surprises. In a way, the pandemic bought us the time we might otherwise have missed. It's nice that you have a pair 👫
Really admire how you’re committed to being present for your kids while juggling so much on your plate. It’s wonderful how you find ways to make memories with them—those years don’t come back, and one day your kids will remember how their mom was there in the big and small moments.
May 20, 2025 at 2:49 AM
Really admire how you’re committed to being present for your kids while juggling so much on your plate. It’s wonderful how you find ways to make memories with them—those years don’t come back, and one day your kids will remember how their mom was there in the big and small moments.
Thank you so much for sharing — sounds like you jumped right into motherhood during one of the most intense phases of training. Do you feel like it got any more manageable as you transitioned to postdoc/faculty, or did the challenges just shift in a different way?
May 20, 2025 at 2:49 AM
Thank you so much for sharing — sounds like you jumped right into motherhood during one of the most intense phases of training. Do you feel like it got any more manageable as you transitioned to postdoc/faculty, or did the challenges just shift in a different way?
🥼🔬📚If you don’t mind sharing, how did you typically divide your time across teaching, clinical work, and research before having children? Like, what was your rough mix in percentages? And how have you adjusted or tipped the balance since raising children came into the picture?🤰👩🍼👼
May 19, 2025 at 6:17 PM
🥼🔬📚If you don’t mind sharing, how did you typically divide your time across teaching, clinical work, and research before having children? Like, what was your rough mix in percentages? And how have you adjusted or tipped the balance since raising children came into the picture?🤰👩🍼👼
🙋🏼♀️ Do you see potential for skin microbiome sampling and analysis to eventually become part of routine dermatology practice in the future, like skin biopsies and dermatopathology are today?
May 19, 2025 at 5:52 PM
🙋🏼♀️ Do you see potential for skin microbiome sampling and analysis to eventually become part of routine dermatology practice in the future, like skin biopsies and dermatopathology are today?
Such a creative graphic!
May 5, 2025 at 5:14 AM
Such a creative graphic!
Definitely adding this to my reading list! I just realized the picture wasn't in the paper 😅. Is this something that AI does whenever we post a link? I'm guessing "the EEC within the GI mucosa?"
April 27, 2025 at 12:07 PM
Definitely adding this to my reading list! I just realized the picture wasn't in the paper 😅. Is this something that AI does whenever we post a link? I'm guessing "the EEC within the GI mucosa?"
And yet I wonder...
How many of these questions could the skin microbiome alone answer?
It can certainly take a village for many of them, especially those of more complex nature—a village of other microbiomes.
3/3
How many of these questions could the skin microbiome alone answer?
It can certainly take a village for many of them, especially those of more complex nature—a village of other microbiomes.
3/3
April 14, 2025 at 7:13 AM
And yet I wonder...
How many of these questions could the skin microbiome alone answer?
It can certainly take a village for many of them, especially those of more complex nature—a village of other microbiomes.
3/3
How many of these questions could the skin microbiome alone answer?
It can certainly take a village for many of them, especially those of more complex nature—a village of other microbiomes.
3/3
Why this location?
Why this process?
Why this lesion—its shape, color, texture, size?
Why this symptom?
Why so long—or so fast?
Why so easy to treat—or so resistant?
Why this trigger?
Why this patient?
Got more Whys?
2/2
Why this process?
Why this lesion—its shape, color, texture, size?
Why this symptom?
Why so long—or so fast?
Why so easy to treat—or so resistant?
Why this trigger?
Why this patient?
Got more Whys?
2/2
April 14, 2025 at 7:07 AM
Why this location?
Why this process?
Why this lesion—its shape, color, texture, size?
Why this symptom?
Why so long—or so fast?
Why so easy to treat—or so resistant?
Why this trigger?
Why this patient?
Got more Whys?
2/2
Why this process?
Why this lesion—its shape, color, texture, size?
Why this symptom?
Why so long—or so fast?
Why so easy to treat—or so resistant?
Why this trigger?
Why this patient?
Got more Whys?
2/2
📌 Meal timing is a potential modifiable lifestyle factor involved in the higher CVD risk in night workers. 5/5
April 13, 2025 at 2:06 PM
📌 Meal timing is a potential modifiable lifestyle factor involved in the higher CVD risk in night workers. 5/5
▫️ Intriguingly, under light cycles of 22 h, which match their intrinsic period (i.e., in resonance), their cyclic behavioral patterns and heart structure and function normalized, indicating the importance of synchrony between the internal circadian clock with environmental and behavioral cycles. 4/
April 13, 2025 at 2:06 PM
▫️ Intriguingly, under light cycles of 22 h, which match their intrinsic period (i.e., in resonance), their cyclic behavioral patterns and heart structure and function normalized, indicating the importance of synchrony between the internal circadian clock with environmental and behavioral cycles. 4/
▫️ A point mutation in the circadian regulatory gene, casein kinase-1, results in an intrinsic circadian period of 22 h (instead of approximately 24 h in wildtypes), early-onset cardiomyopathy, extensive fibrosis, and severely impaired contractility. 3/
April 13, 2025 at 2:06 PM
▫️ A point mutation in the circadian regulatory gene, casein kinase-1, results in an intrinsic circadian period of 22 h (instead of approximately 24 h in wildtypes), early-onset cardiomyopathy, extensive fibrosis, and severely impaired contractility. 3/
▫️Circadian disruption might induce hypofibrinolysis and increase cardiovascular risk by inducing PAI-1 gene expression following circadian misalignment. 2/
April 13, 2025 at 2:06 PM
▫️Circadian disruption might induce hypofibrinolysis and increase cardiovascular risk by inducing PAI-1 gene expression following circadian misalignment. 2/
The problem is, it seems like AI doesn’t truly have an independent ability to discern whether a user is correct or whether certain data is trustworthy—and that creates a critical loophole. 2/4
April 13, 2025 at 1:24 PM
The problem is, it seems like AI doesn’t truly have an independent ability to discern whether a user is correct or whether certain data is trustworthy—and that creates a critical loophole. 2/4