Shalini
@shalz15.bsky.social
PhD candidate at UCL Mental Health Science
@wellcometrust
@wellcometrust
recent clinical trial by Leanne Williams and colleagues investigated guanfacine, an α2A adrenoreceptor agonist traditionally used for high blood pressure, as a targeted treatment for a neurobiologically defined cognitive biotype of major depressive disorder.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
A stratified precision medicine trial targeting α2A-adrenergic receptor agonism as a treatment for the cognitive biotype of depression - Nature Mental Health
This study demonstrates that guanfacine immediate release enhances cognitive control circuit function and behavioral performance in a neurobiologically defined cognitive biotype of depression, achieving a 76.5% clinical response rate and improving life satisfaction, marking a promising advance in precision medicine.
www.nature.com
October 13, 2025 at 12:05 PM
recent clinical trial by Leanne Williams and colleagues investigated guanfacine, an α2A adrenoreceptor agonist traditionally used for high blood pressure, as a targeted treatment for a neurobiologically defined cognitive biotype of major depressive disorder.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Excellent opportunity with an amazing supervisor @uclbrainscience.bsky.social
I'm hiring! ✨ Looking for a Research Fellow to study environmental factors that mitigate intergenerational transmission of mental health.
3-year post at UCL @uclbrainscience.bsky.social with great opportunities for training, collaboration & exciting science!
🔗 Apply: www.jobs.ac.uk/job/DOZ633/r...
3-year post at UCL @uclbrainscience.bsky.social with great opportunities for training, collaboration & exciting science!
🔗 Apply: www.jobs.ac.uk/job/DOZ633/r...
Research Fellow in Mental Health at UCL
Apply for the Research Fellow in Mental Health role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.
www.jobs.ac.uk
October 10, 2025 at 9:48 AM
Excellent opportunity with an amazing supervisor @uclbrainscience.bsky.social
Pharmacogenomic(PGx)testing can guide mental health treatment by predicting which meds work best for each patient. Faster response, fewer side effects. For example, CYP2C19 poor metabolizers may need a 50% sertraline dose. A tool worth considering for #GPs & #psychiatrists.
shorturl.at/X827X
shorturl.at/X827X
The Use of Pharmacogenomics in Mental Health
Pharmacogenomics (PGx) offers a personalized approach to treating mental health disorders,
like depression, by using an individual's genetic profile to guide medication selection
and dosage. This appr...
shorturl.at
June 15, 2025 at 11:44 AM
Pharmacogenomic(PGx)testing can guide mental health treatment by predicting which meds work best for each patient. Faster response, fewer side effects. For example, CYP2C19 poor metabolizers may need a 50% sertraline dose. A tool worth considering for #GPs & #psychiatrists.
shorturl.at/X827X
shorturl.at/X827X
Stark Reality - almost half of those who take #antidepressants have tried at least two drugs without success & about third have tried four drugs without success, findings revealed severe emotional distress and frustration with existing treatments amongst patients .
www.cambridge.org/core/journal...
www.cambridge.org/core/journal...
www.cambridge.org
May 3, 2025 at 9:46 AM
Stark Reality - almost half of those who take #antidepressants have tried at least two drugs without success & about third have tried four drugs without success, findings revealed severe emotional distress and frustration with existing treatments amongst patients .
www.cambridge.org/core/journal...
www.cambridge.org/core/journal...
Thank you so much to our wonderful steering committee members (incl. @jonroiser.bsky.social @alexandrapitman.bsky.social @annaremington.bsky.social) for making this possible.
@anabellepauli.bsky.social @lunahuestegge.bsky.social @shalz15.bsky.social @steveallsopp.bsky.social
And our eternal gratitude to the programme steering committee (incl. @jonroiser.bsky.social @alexandrapitman.bsky.social @annaremington.bsky.social) for guiding us through our PhD journeys!
And our eternal gratitude to the programme steering committee (incl. @jonroiser.bsky.social @alexandrapitman.bsky.social @annaremington.bsky.social) for guiding us through our PhD journeys!
March 4, 2025 at 7:51 PM
Thank you so much to our wonderful steering committee members (incl. @jonroiser.bsky.social @alexandrapitman.bsky.social @annaremington.bsky.social) for making this possible.
Reposted by Shalini
@anabellepauli.bsky.social @lunahuestegge.bsky.social @shalz15.bsky.social @steveallsopp.bsky.social
And our eternal gratitude to the programme steering committee (incl. @jonroiser.bsky.social @alexandrapitman.bsky.social @annaremington.bsky.social) for guiding us through our PhD journeys!
And our eternal gratitude to the programme steering committee (incl. @jonroiser.bsky.social @alexandrapitman.bsky.social @annaremington.bsky.social) for guiding us through our PhD journeys!
March 4, 2025 at 5:59 PM
@anabellepauli.bsky.social @lunahuestegge.bsky.social @shalz15.bsky.social @steveallsopp.bsky.social
And our eternal gratitude to the programme steering committee (incl. @jonroiser.bsky.social @alexandrapitman.bsky.social @annaremington.bsky.social) for guiding us through our PhD journeys!
And our eternal gratitude to the programme steering committee (incl. @jonroiser.bsky.social @alexandrapitman.bsky.social @annaremington.bsky.social) for guiding us through our PhD journeys!
Heart disease prediction model achieved 95% accuracy using advanced AI techniques like feature selection, data balancing,&deep learning. Potential to adapt this for mental health could be incredible-for early diagnosis, personalized care, biomarkers await!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Comprehensive evaluation and performance analysis of machine learning in heart disease prediction - Scientific Reports
Scientific Reports - Comprehensive evaluation and performance analysis of machine learning in heart disease prediction
www.nature.com
December 20, 2024 at 8:28 PM
Heart disease prediction model achieved 95% accuracy using advanced AI techniques like feature selection, data balancing,&deep learning. Potential to adapt this for mental health could be incredible-for early diagnosis, personalized care, biomarkers await!
www.nature.com/articles/s41...
www.nature.com/articles/s41...