William Morton
@shakespearem.bsky.social
Aspiring to cringy posts about academic life
Special thanks to Marek Šebesta for answering countless questions, Robert Vácha for mentorship, @labvacha.bsky.social for support.
Discussions with Balázs Fábián, David DeSancho, and Guilio Tesei helped to greatly improve the quality of my work!
Discussions with Balázs Fábián, David DeSancho, and Guilio Tesei helped to greatly improve the quality of my work!
February 7, 2025 at 8:00 AM
Special thanks to Marek Šebesta for answering countless questions, Robert Vácha for mentorship, @labvacha.bsky.social for support.
Discussions with Balázs Fábián, David DeSancho, and Guilio Tesei helped to greatly improve the quality of my work!
Discussions with Balázs Fábián, David DeSancho, and Guilio Tesei helped to greatly improve the quality of my work!
Massive thanks to everyone at CEITEC for their collaboration, patience, and support!
There’s still work ahead, but this is a big step forward. 🚀
📜 Read the preprint here: www.biorxiv.org/content/10.1...
💻 Check out the code here: github.com/shakespearem...
There’s still work ahead, but this is a big step forward. 🚀
📜 Read the preprint here: www.biorxiv.org/content/10.1...
💻 Check out the code here: github.com/shakespearem...
Mechanisms of transcription attenuation and condensation of RNA polymerase II by RECQ5
The elongation rates of RNA polymerase II (RNAPII) require precise control to prevent transcriptional stress, which can impede co-transcriptional pre-mRNA processing and contribute to many age- or dis...
www.biorxiv.org
February 7, 2025 at 7:59 AM
Massive thanks to everyone at CEITEC for their collaboration, patience, and support!
There’s still work ahead, but this is a big step forward. 🚀
📜 Read the preprint here: www.biorxiv.org/content/10.1...
💻 Check out the code here: github.com/shakespearem...
There’s still work ahead, but this is a big step forward. 🚀
📜 Read the preprint here: www.biorxiv.org/content/10.1...
💻 Check out the code here: github.com/shakespearem...
3/n
This project was a huge shift for me—moving from designing metal alloys as a materials engineer to simulating biological systems. It’s been a journey with many iterations, but taking this work to conferences throughout the year has helped refine both the research and the questions I ask.
This project was a huge shift for me—moving from designing metal alloys as a materials engineer to simulating biological systems. It’s been a journey with many iterations, but taking this work to conferences throughout the year has helped refine both the research and the questions I ask.
February 7, 2025 at 7:58 AM
3/n
This project was a huge shift for me—moving from designing metal alloys as a materials engineer to simulating biological systems. It’s been a journey with many iterations, but taking this work to conferences throughout the year has helped refine both the research and the questions I ask.
This project was a huge shift for me—moving from designing metal alloys as a materials engineer to simulating biological systems. It’s been a journey with many iterations, but taking this work to conferences throughout the year has helped refine both the research and the questions I ask.
2/n
The Complex Version:
RECQ5 binds to RNA Polymerase II (RNAP) at the DNA entry site 👉👈. It forms its own condensates and can recruit RNAP when the C-Terminal Domain is hyper-phosphorylated. This suggests a complex network of interactions—one we explore in detail in our preprint. 🕸️
The Complex Version:
RECQ5 binds to RNA Polymerase II (RNAP) at the DNA entry site 👉👈. It forms its own condensates and can recruit RNAP when the C-Terminal Domain is hyper-phosphorylated. This suggests a complex network of interactions—one we explore in detail in our preprint. 🕸️
February 7, 2025 at 7:58 AM
2/n
The Complex Version:
RECQ5 binds to RNA Polymerase II (RNAP) at the DNA entry site 👉👈. It forms its own condensates and can recruit RNAP when the C-Terminal Domain is hyper-phosphorylated. This suggests a complex network of interactions—one we explore in detail in our preprint. 🕸️
The Complex Version:
RECQ5 binds to RNA Polymerase II (RNAP) at the DNA entry site 👉👈. It forms its own condensates and can recruit RNAP when the C-Terminal Domain is hyper-phosphorylated. This suggests a complex network of interactions—one we explore in detail in our preprint. 🕸️
Beautifully put together results.
January 23, 2025 at 10:59 AM
Beautifully put together results.