(2/12) The human genome encodes ~1.5 thousand transcription factors (TFs), and hundreds of them still lack "DNA motifs", i.e., compact human- and machine-readable representations of the TF-DNA binding specificity.

(3/12) There are a multitude of high-throughput methods for assessing the DNA binding specificity of transcription factors. The variety of existing motif discovery tools is even greater. Which one to use?