Amazing work by first author @shouyafeng.bsky.social with the support of @hudsonresearch.bsky.social and many others!!!

We tested this library of NLRP3 variants in response to stimulation, at low temperature (some patients with CAPS have temperature sensitive flares), and in response to a NLRP3 inhibitor, all of which yielded interesting results. If you have another idea, we are happy to share the library with you!

Data available through
infevers.umai-montpellier.fr
and
www.geniadb.net/app/gene/inf...
any variants we did not test yet please let me know!

My apologies, it looks like this meeting is not being broadcast. Depending on what you are interested to hear about, there could be some recordings or other resources I can point you towards.

A really important consideration in the study of #autoinflammatory and other primary immune diseases. Extremely interesting findings @bogunoviclab.bsky.social !