Sebastiano Trattaro
@sebastianotrattaro.bsky.social
Scientist, Postdoctoral researcher at Harvard and The Broad @ArlottaLab
Reposted by Sebastiano Trattaro
New preprint alert 📣
#Cerebellum, organoid, autism & brain evolution 🧪 🧫🧠🧬
Collaboration with G. Testa; fruit of years of work by smart students, led by postdoc Davide Aprile. Organoids to understand better the developmental basis of autism (focus: CHD8) & sapiens brain evolution (focus: CADPS2) 🧵
#Cerebellum, organoid, autism & brain evolution 🧪 🧫🧠🧬
Collaboration with G. Testa; fruit of years of work by smart students, led by postdoc Davide Aprile. Organoids to understand better the developmental basis of autism (focus: CHD8) & sapiens brain evolution (focus: CADPS2) 🧵
Benchmarking cerebellar organoids to model autism spectrum disorder and human brain evolution
While cortical organoids have been used to model different facets of neurodevelopmental conditions and human brain evolution, cerebellar organoids have not yet featured so prominently in the same cont...
www.biorxiv.org
May 16, 2025 at 11:08 AM
New preprint alert 📣
#Cerebellum, organoid, autism & brain evolution 🧪 🧫🧠🧬
Collaboration with G. Testa; fruit of years of work by smart students, led by postdoc Davide Aprile. Organoids to understand better the developmental basis of autism (focus: CHD8) & sapiens brain evolution (focus: CADPS2) 🧵
#Cerebellum, organoid, autism & brain evolution 🧪 🧫🧠🧬
Collaboration with G. Testa; fruit of years of work by smart students, led by postdoc Davide Aprile. Organoids to understand better the developmental basis of autism (focus: CHD8) & sapiens brain evolution (focus: CADPS2) 🧵
New preprint from the Testa and @cedricboeckx.bsky.social groups! Very cool technological implementation and results about human evolution using brain organoids! Congrats to @adrianosskaros.bsky.social @alessandrovitriolo.bsky.social and all coauthors!
Delighted to share our new preprint, the outcome of many years of collaborative work with Giuseppe Testa’s group, both at the bench & in front of the computer, probing human brain evolution using organoids. We tried something cool, and learned a lot 🧪🧫🧠🧬
[follow 🧵]
www.biorxiv.org/content/10.1...
[follow 🧵]
www.biorxiv.org/content/10.1...
Regulatory logic of human cortex evolution by combinatorial perturbations
Comparative genomic studies between contemporary and extinct hominins revealed key evolutionary modifications, but their number has hampered a system level investigation of their combined roles in sca...
www.biorxiv.org
May 2, 2025 at 3:12 PM
New preprint from the Testa and @cedricboeckx.bsky.social groups! Very cool technological implementation and results about human evolution using brain organoids! Congrats to @adrianosskaros.bsky.social @alessandrovitriolo.bsky.social and all coauthors!
Have a look at this amazing work from the Giuseppe Testa’s lab using brain organoids to model the effect of ADNP mutations in neurodevelopment. Congrats to @ludoritz.bsky.social @alessandrovitriolo.bsky.social and everyone involved!
I'm happy to share our work on the neurodevelopmental impact of ADNP mutations in ASD and beyond. It has been an exciting ride to share with @alessandrovitriolo.bsky.social, Mariana, and the people of the Testa and Poot Labs.
Full paper here:
www.biorxiv.org/content/10.1...
Thread below 🧵
Full paper here:
www.biorxiv.org/content/10.1...
Thread below 🧵
www.biorxiv.org
May 2, 2025 at 3:04 PM
Have a look at this amazing work from the Giuseppe Testa’s lab using brain organoids to model the effect of ADNP mutations in neurodevelopment. Congrats to @ludoritz.bsky.social @alessandrovitriolo.bsky.social and everyone involved!