For more details, check out the full study here: doi.org/10.3389/fend...
#CancerResearch #StromalBiology (8/8)

Our findings suggest that fibroblasts and macrophages play significant roles in the HNPGN tumor microenvironment. This adds to our understanding of the composition and activity of these tumors. (7/8)

In situ confocal microscopy showed that MCT1 & MCT4 were expressed in both HNPGN tumor cells and stromal macrophages. This points to potential metabolic interactions in the #TumorMicroenvironment. (6/8)

Fibroblasts derived from HNPGN expressed PDPN, as seen in healthy tissue fibroblasts, and markers like FAP, MCT1, CD220, & CD222 (via #FlowCytometry). These markers reflect their functional properties. (5/8)

RT-qPCR analysis confirmed the expression of macrophage- and fibroblast-associated molecules in HNPGN samples. These findings highlight the active role of stromal cells in these tumors. (4/8)

Using #Immunohistochemistry, we identified:
> CD68+ & CD163+ macrophages
> CD90+ & PDPN+ fibroblasts
These stromal cells were present in HNPGN tissues and may contribute to tumour behaviour. (3/8)

First, a shout out to the wonderful collaborators! Paramita Baruah, Jennifer L. Marshall, Meriam Nefla, Valentina Pucino, Holly Adams, Jason D. Turner, Emily Powell, Georgiana Neag, Peter Monksfield, Richard M. Irving, Adam P. Croft, Ingrid E. Dumitriu and Christopher D. Buckley (2/8)