It was great to see the Hardaway lab’s exciting data on GLP1 in the central amygdala. We enjoyed your visit.

7/
Grateful to our collaborators and lab team for their insights and dedication.
📄 Read the full study: sciencedirect.com/science/arti...
#Neurobiology #Endocannabinoids #MentalHealth #ScienceThread #Norepinephrine

6/
This context-dependent modulation hints at a more sophisticated role for CB1 signaling in emotional regulation. It may help explain why cannabinoid-based therapies show variable effects across individuals and conditions.

5/
Our findings? The absence of CB1 receptors in these neurons did not uniformly increase or decrease stress responses. Instead, the effects varied depending on the context—suggesting a nuanced, situation-specific role.

4/
Using conditional knockout models, we selectively deleted CB1 receptors from NE/EPI neurons. This allowed us to isolate their contribution to stress-related behaviors without affecting CB1 signaling elsewhere.

3/ We found CB1R transcript is widely found in NE and EPI neurons of C1/A1 and C2/A2, with sparse LC expression.

2/
The endocannabinoid system is known to regulate emotional responses, but its role in catecholaminergic neurons—those producing NE and EPI—has been less clear. We explored how CB1 receptor signaling in these neurons affects stress reactivity.

Congrats Dionnet! Looks strong

Congrats McElligott lab!!!

Congratulations!!! So well deserved

Great sports!

Glad you are out of the house. I’m going stir crazy with 7 days of no school for the kiddo

Strange, just verified my email, maybe it will work now. Thanks again!!!

Thanks for compiling this! Add me too please.