Fungus is raising awareness of something true and serious, which you don’t seem to completely understand, it’s important to take her seriously.

I second that, and agree with you on that point.

Pas de ce que je me souviens, par contre on a la variante qui touche les cervides (cerfs, biches) comme le "Chronic Waste Disease" qui peut etre problematiques pour les amateurs de la viande de gibier (quoique on a pas de preuve de transmission a l'humain).

These clicks not gonna click themselves :p

You are welcome! Again this is my personal opinion and would like to hear from seasoned colleagues more akin on brain drug delivery. But thing is certain: the headline is too sensational and clickbait. Oh well, PhDComics had it summarized well this issue :)

I would say, this delivery vector looks promising if you are pushing for antisense oligonucleotides delivery into the brain, but I have hard time seeing it being translated for other small molecules (liposomes being so far the best we can do) or larger molecules (bispecific TfR antibodies kind work)

My biggest concern? How did the authors ensured samples were taken and maintained under sterile conditions? Nowhere it is written and this is for me some serious concerns. You want samples extracted and frozen in a clean room, otherwise we end up with the same issue than meteorite.

You are welcome. The pathobiome in AD makes sense, but the whole brain microbiome? As now it is a pre-print only, and seeing The Guardian buzzing off a pre-print is for me like someone trying to sell you a bear hide before actually having taken care of it. www.biorxiv.org/content/10.1...

Reviving this discussion. Yes, they used fresh human tissue. It is better than nothing (helluva to do brain PK in humans), the penetration rate (as %injected dose/g brain tissue) is rather impressive (~3% versus ~0.1% with antibodies like lenacemab/donanemab) but still we are delivering small cargo.

As a primer, link to the paper: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...