sciencedad.bsky.social
@sciencedad.bsky.social
First GABA transporter 3, GAT3, structure is out!! We have successfully captured the transporter both to an in-house developed inhibitor, the substrate GABA, and apo state. Go read it before your neighbour:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Structural basis for selective inhibition of human GABA transporter GAT3
The astrocytic γ-aminobutyric acid (GABA) transporter, GAT3, is essential for terminating GABAergic signalling in the central nervous system. Selective inhibition of GAT3 offers a potential strategy f...
www.biorxiv.org
March 29, 2025 at 3:46 PM
First GABA transporter 3, GAT3, structure is out!! We have successfully captured the transporter both to an in-house developed inhibitor, the substrate GABA, and apo state. Go read it before your neighbour:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...