NASA Administrator Jared Isaacman, who was confirmed by the Senate just last week after a turbulent nomination process that stretched across most of 2025, said Friday that the United States will return to the moon within President Donald Trump's second term. Isaacman made the comments during an interview on CNBC, calling Trump's recommitment to lunar exploration key to unlocking what he described as an "orbital economy." He said: "We want to have that opportunity to explore and realize the scientific, economic and national security potential on the moon," he said. The potential opportunities include establishing space data centers and infrastructure on the moon, as well as mining Helium-3, a rare gas embedded in the lunar surface that could serve as fuel for fusion power. NASA is currently working on its Artemis campaign alongside SpaceX, Blue Origin, and Boeing. Trump's One Big Beautiful Bill Act allocated $9.9 billion to the agency earlier this year. The Artemis II mission, NASA's first crewed test flight using the Space Launch System rocket and Orion spacecraft, is expected to launch in the near future. SpaceX is contracted to build the lunar landing system for the subsequent Artemis III mission. Isaacman was first nominated by Trump in December 2024 but had his nomination pulled in May over unspecified "prior associations." Trump renominated him in November. Read more of this story at Slashdot.

The first-ever commercial rocket launched at Brazil's Alcantara Space Center crashed soon after liftoff late earlier this week, dealing a blow to Brazilian aerospace ambitions and shares of South Korean satellite launch company Innospace. From a report: The rocket began its vertical trajectory as planned after liftoff [Monday] at 10:13 p.m. local time (0113 GMT) but fell to the ground after something went wrong 30 seconds into its flight, Innospace CEO Kim Soo-jong said in a letter to shareholders. The craft crashed within a pre-designated safety zone and did not harm anyone, he said. Brazil's air force said firefighters were sent to analyze the wreckage and impact zone. "We are deeply sorry that we failed to meet the expectations of our shareholders who supported our first commercial launch," the CEO wrote in the letter, which was posted on the company's website on December 23. Innospace shares plunged nearly 29% in Seoul in its biggest daily drop and heaviest daily trading volume since its July 2024 listing. Read more of this story at Slashdot.

NASA has lost contact with its MAVEN Mars orbiter after it passed behind Mars. When it remerged from behind the planet, the spacecraft never resumed communications. SpaceNews reports: MAVEN launched in November 2013 and entered orbit around Mars in September 2014. The spacecraft's primary science mission is to study the planet's upper atmosphere and interactions with the solar wind, including how the atmosphere escapes into space. That is intended to help scientists understand how the planet changes from early in its history, when it had a much thicker atmosphere and was warm enough to support liquid water on its surface. MAVEN additionally serves as a communications relay, using a UHF antenna to link the Curiosity and Perseverance rovers on the Martian surface with the Deep Space Network. NASA's Mars Odyssey and Mars Reconnaissance Orbiter spacecraft also serve as communications relays for the rovers, but are both significantly older than MAVEN. The spacecraft has suffered some technical problems in the past, notably with its inertial measurement units (IMUs) used for navigation. In 2022, MAVEN switched to an "all-stellar" navigation system to minimize the use of the IMUs. MAVEN has enough propellant to maintain its orbit through at least the end of the decade. NASA's fiscal year 2026 budget proposal, though, zeroed out funding for MAVEN, which cost $22.6 million to operate in 2024. MAVEN was one of several missions "operating well past the end of prime mission" the proposal would terminate, despite MAVEN's role as a communications relay. Read more of this story at Slashdot.

A major scientific report published Tuesday argues that sending astronauts to Mars is justified by the quest to find life and conduct research that robots alone can't achieve. "We're searching for life on Mars," said Dava Newman, a professor in the Department of Aeronautics and Astronautics at Massachusetts Institute of Technology and co-chair of the committee that wrote the report. "The answer to the question 'are we alone' is always going to be 'maybe,' unless it becomes yes." Ars Technica reports: The report, two years in the making and encompassing more than 200 pages, was published by the National Academies of Sciences, Engineering, and Medicine. Essentially, the committee co-chaired by Newman and Linda T. Elkins-Tanton, director of the University of California, Berkeley Space Sciences Laboratory, was asked to identify the highest-priority science objectives for the first human missions to Mars. [...] "There's no turning back," Newman said. "Everyone is inspired by this because it's becoming real. We can get there. Decades ago, we didn't have the technologies. This would have been a study report." The goal of the report is to help build a case for meaningful science to be done on Mars alongside human exploration. The report outlines 11 top-priority science objectives. [...] The committee also looked at different types of campaigns to determine which would be most effective for completing the science objectives noted above. The campaign most likely to be successful, they found, was an initial human landing that lasts 30 days, followed by an uncrewed cargo delivery to facilitate a longer 300-day crewed mission on the surface of Mars. All of these missions would take place in a single exploration zone, about 100 km in diameter, that featured ancient lava flows and dust storms. Notably, the report also addresses the issue of planetary protection, a principle that aims to protect both celestial bodies (i.e., the surface of Mars) and visitors (i.e., astronauts) from biological contamination. [...] In recent years, NASA has been working with the International Committee on Space Research to design a plan in which human landings might occur in some areas of the planet, while other parts of Mars are left in "pristine" condition. The committee said this work should be prioritized to reach a resolution that will further the design of human missions to Mars. "NASA should continue to collaborate on the evolution of planetary protection guidelines, with the goal of enabling human explorers to perform research in regions that could possibly support, or even harbor, life," the report states. Read more of this story at Slashdot.

schwit1 shares a report from CNN: A private Chinese space firm successfully sent its Zhuque-3 rocket to orbit but failed in its historic attempt to re-land the rocket booster Wednesday -- the first such trial by a Chinese firm as the country's growing commercial space sector races to catch up with American rivals like SpaceX. The rocket entered orbit as planned, but its first stage did not successfully return to a landing site, instead crashing down, the company said in a statement. "An anomaly occurred after the first-stage engine ignited during the landing phase, preventing a soft landing on the designated recovery pad," the statement said. "The debris landed at the edge of the recovery area, resulting in a failed recovery test." The team would "conduct a comprehensive review" and continue to "advance the verification and application of reusable rocket technology in future missions," the statement added. You can watch a video of the launch and subsequent crash here. Read more of this story at Slashdot.

Bruce66423 shares a report from the Los Angeles Times: Tattoo ink doesn't just sit inertly in the skin. New research shows it moves rapidly into the lymphatic system, where it can persist for months, kill immune cells, and even disrupt how the body responds to vaccines. Scientists in Switzerland used a mouse model to trace what happens after tattooing. Pigments drained into nearby lymph nodes within minutes and continued to accumulate for two months, triggering immune-cell death and sustained inflammation. The ink also weakened the antibody response to Pfizer Inc. and BioNTech SE's COVID vaccine when the shot was administered in tattooed skin. In contrast, the same inflammation appeared to boost responses to an inactivated flu vaccine. "This work represents the most extensive study to date regarding the effect of tattoo ink on the immune response and raises serious health concerns associated with the tattooing practice," the researchers said. "Our work underscores the need for further research to inform public health policies and regulatory frameworks regarding the safety of tattoo inks." The findings have been published in the journal Proceedings of the National Academy of Sciences. Read more of this story at Slashdot.

An anonymous reader quotes a report from the New York Times: The San Francisco city attorney filed on Tuesday the nation's first government lawsuit against food manufacturers over ultraprocessed fare (source may be paywalled; alternative source), arguing that cities and counties have been burdened with the costs of treating diseases that stem from the companies' products. David Chiu, the city attorney, sued 10 corporations that make some of the country's most popular food and drinks. Ultraprocessed products now comprise 70 percent of the American food supply and fill grocery store shelves with a kaleidoscope of colorful packages. Think Slim Jim meat sticks and Cool Ranch Doritos. But also aisles of breads, sauces and granola bars marketed as natural or healthy. It is a rare issue on which the liberal leaders in San Francisco City Hall are fully aligned with the Trump administration, which has targeted ultraprocessed foods as part of its Make America Healthy Again mantra. Mr. Chiu's lawsuit, which was filed in San Francisco Superior Court on behalf of the State of California, seeks unspecified damages for the costs that local governments bear for treating residents whose health has been harmed by ultraprocessed food. The city accuses the companies of "unfair and deceptive acts" in how they market and sell their foods, arguing that such practices violate the state's Unfair Competition Law and public nuisance statute. The city also argues the companies knew that their food made people sick but sold it anyway. Read more of this story at Slashdot.

An anonymous reader shared this report from The Conversation: To make interplanetary travel faster, safer, and more efficient, scientists need breakthroughs in propulsion technology. Artificial intelligence is one type of technology that has begun to provide some of these necessary breakthroughs. We're a team of engineers and graduate students who are studying how AI in general, and a subset of AI called machine learning in particular, can transform spacecraft propulsion. From optimizing nuclear thermal engines to managing complex plasma confinement in fusion systems, AI is reshaping propulsion design and operations. It is quickly becoming an indispensable partner in humankind's journey to the stars... Early nuclear thermal propulsion designs from the 1960s, such as those in NASA's NERVA program, used solid uranium fuel molded into prism-shaped blocks. Since then, engineers have explored alternative configurations — from beds of ceramic pebbles to grooved rings with intricate channels... [T]he more efficiently a reactor can transfer heat from the fuel to the hydrogen, the more thrust it generates. This area is where reinforcement learning has proved to be essential. Optimizing the geometry and heat flow between fuel and propellant is a complex problem, involving countless variables — from the material properties to the amount of hydrogen that flows across the reactor at any given moment. Reinforcement learning can analyze these design variations and identify configurations that maximize heat transfer. Read more of this story at Slashdot.

Twenty years after surgeons in France performed the world's first face transplant, the experimental field that procedure launched is now confronting a troubling record of patient deaths, buried negative data and a healthcare system that leaves recipients financially devastated and medically vulnerable. About 50 face transplants have been performed globally since Isabelle Dinoire received her partial face graft at University Hospital CHU Amiens-Picardie in November 2005. A 2024 JAMA Surgery study reported five-year graft survival of 85% and 10-year survival of 74%, concluding that the procedure is "an effective reconstructive option for patients with severe facial defects." The study did not track psychological wellbeing, financial outcomes, employment status or quality of life. Roughly 20% of face transplant patients have died from rejection, kidney failure, or heart failure. The anti-rejection medications that keep transplanted faces alive can destroy kidneys and weaken immune systems to the point where routine infections become life-threatening. In the United States, the Department of Defense has funded most operations, treating them as a frontier for wounded veterans, because private insurers refuse to cover the costs. Patients who survive the surgery often find themselves unable to afford medications, transportation to follow-up appointments or basic caregiving. The field's long-term grants cover surgical innovation but not the lifelong needs of the people who receive these transplants. Read more of this story at Slashdot.

China's pharmaceutical industry has quietly evolved from a hub for generics and clinical trials into something more ambitious -- a genuine competitor in drug discovery that Western giants are now courting to fill gaps left by looming patent expirations worth over $300 billion by 2030. In the first half of 2025, nearly a third of global licensing agreements signed by big pharma involved Chinese firms, Economist reports, four times the share from 2021. Pfizer agreed in May to pay $1.25 billion to 3SBio for an experimental cancer drug, and GlaxoSmithKline followed in June with a deal valued at up to $12 billion with Hengrui. Chinese companies now run about a third of the world's clinical trials, up from 5% a decade ago. Read more of this story at Slashdot.

An anonymous reader shares a report: It is shocking but not surprising. Lightning crackles on Mars, scientists reported on Wednesday. What they observed, however, were not jagged, high-voltage bolts like those on Earth, arcing thousands of feet from cloud to ground. Rather, the phenomenon was more like the shock you feel when you scuff your feet on the carpet on a cold winter morning and then touch a metal doorknob. "This is like mini-lightning on Mars," Baptiste Chide, a scientist at the Research Institute in Astrophysics and Planetary Science in Toulouse, France, said of the centimeter-scale electrical discharges. Dr. Chide and his colleagues reported the findings in a paper published on Wednesday in the journal Nature. The electrical sparks, although not as dramatically violent as on Earth, could play an important role in chemical reactions in the Martian atmosphere. Read more of this story at Slashdot.

China launched an uncrewed Shenzhou 22 spacecraft to serve as an emergency lifeboat for three astronauts aboard the Tiangong space station after a docked return craft was found to have a cracked window likely caused by space debris. "A Long March 2F rocket fired its engines and lifted off with the Shenzhou 22 spacecraft, carrying cargo instead of a crew, at 11:11 pm EST Monday (04:11 UTC Tuesday)," reports Ars Technica. "The spacecraft docked with the Tiangong station nearly 250 miles (400 kilometers) above the Earth about three-and-a-half hours later." From the report: Chinese engineers worked fast to move up the launch of the Shenzhou 22, originally set to fly next year. On November 4, astronauts discovered one of the two crew ferry ships docked to the Tiangong station had a damaged window, likely from an impact with a small fragment of space junk. [...] Now, 20 days after the saga began, the Tiangong outpost again has a lifeboat for its long-term residents. Astronauts Zhang Lu, Fu Wei, and Zhang Hongzhang will return to Earth on the Shenzhou 22 spacecraft next year, soon after the arrival of their three replacements. The Tiangong astronauts will head outside the station on a spacewalk to inspect the damaged window on Shenzhou 20. Eventually, Shenzhou 20 will depart Tiangong and reenter the atmosphere with cargo. Assuming a smooth landing, Chinese engineers will have an opportunity to get a closer look at the damage on the ground to inform the design of future spacecraft. A preliminary assessment of the window indicates the crack is in the outermost layer of heat-insulating glass in Shenzhou 20's porthole window, according to Chinese state media. Engineers on the ground conducted simulations and wind tunnel ablation tests to determine whether the window might fail during reentry. "The results showed that the cracks would still propagate further," reported CCTV, China's government-run television network. "We held review meeting, and everyone agreed that ensuring the safe return of the astronauts was too risky with the glass damaged," Zhou said. While this crew is just one month into their planned six-month expedition, an emergency could force them to leave the station and return home at any time. Although remote, another collision with space junk, a major systems failure, or a medical emergency involving one of the astronauts could trigger an evacuation. That's why Chinese officials wanted to quickly launch Shenzhou 22 to give the crew a ticket home.The International Space Station follows the same policy, with SpaceX's Dragon spacecraft and Russian Soyuz ships serving as lifeboats until their crews' scheduled return to Earth. Read more of this story at Slashdot.

fahrbot-bot shares a report from Phys.org: Physicists from Swansea University have played the leading role in a scientific breakthrough at CERN, developing an innovative technique that increases the antihydrogen trapping rate by a factor of ten. The advancement, achieved as part of the international Antihydrogen Laser Physics Apparatus (ALPHA) collaboration, has been published in Nature Communications and could help answer one of the biggest questions in physics: Why is there such a large imbalance between matter and antimatter? According to the Big Bang theory, equal amounts were created at the beginning of the universe, so why is the world around us made almost entirely of matter? Antihydrogen is the "mirror version" of hydrogen, made from an antiproton and a positron. Trapping and studying it helps scientists explore how antimatter behaves, and whether it follows the same rules as matter. Producing and trapping antihydrogen is an extremely complicated process. Previous methods took 24 hours to trap just 2,000 atoms, limiting the scope of experiments at ALPHA. The Swansea-led team has changed that. Using laser-cooled beryllium ions, the team has demonstrated that it is possible to cool positrons to less than 10 Kelvin (below -263C), significantly colder than the previous threshold of about 15 Kelvin. These cooler positrons dramatically boost the efficiency of antihydrogen production and trapping -- allowing a record 15,000 atoms to be trapped in less than seven hours. Read more of this story at Slashdot.

An anonymous reader shares a report: For the past several years, America has been using its young people as lab rats in a sweeping, if not exactly thought-out, education experiment. Schools across the country have been lowering standards and removing penalties for failure. The results are coming into focus. Five years ago, about 30 incoming freshmen at UC San Diego arrived with math skills below high-school level. Now, according to a recent report from UC San Diego faculty and administrators, that number is more than 900 -- and most of those students don't fully meet middle-school math standards. Many students struggle with fractions and simple algebra problems. Last year, the university, which admits fewer than 30 percent of undergraduate applicants, launched a remedial-math course that focuses entirely on concepts taught in elementary and middle school. (According to the report, more than 60 percent of students who took the previous version of the course couldn't divide a fraction by two.) One of the course's tutors noted that students faced more issues with "logical thinking" than with math facts per se. They didn't know how to begin solving word problems. The university's problems are extreme, but they are not unique. Over the past five years, all of the other University of California campuses, including UC Berkeley and UCLA, have seen the number of first-years who are unprepared for precalculus double or triple. George Mason University, in Virginia, revamped its remedial-math summer program in 2023 after students began arriving at their calculus course unable to do algebra, the math-department chair, Maria Emelianenko, told me. "We call it quantitative literacy, just knowing which fraction is larger or smaller, that the slope is positive when it is going up," Janine Wilson, the chair of the undergraduate economics program at UC Davis, told me. "Things like that are just kind of in our bones when we are college ready. We are just seeing many folks without that capability." Part of what's happening here is that as more students choose STEM majors, more of them are being funneled into introductory math courses during their freshman year. But the national trend is very clear: America's students are getting much worse at math. The decline started about a decade ago and sharply accelerated during the coronavirus pandemic. The average eighth grader's math skills, which rose steadily from 1990 to 2013, are now a full school year behind where they were in 2013, according to the National Assessment of Educational Progress, the gold standard for tracking academic achievement. Students in the bottom tenth percentile have fallen even further behind. Only the top 10 percent have recovered to 2013 levels. Read more of this story at Slashdot.

An anonymous reader quotes a report from the New York Times: For the first time, scientists are tracking the migration of monarch butterflies across much of North America, actively monitoring individual insects on journeys from as far away as Ontario all the way to their overwintering colonies in central Mexico. This long-sought achievement could provide crucial insights into the poorly understood life cycles of hundreds of species of butterflies, bees and other flying insects at a time when many are in steep decline. The breakthrough is the result of a tiny solar-powered radio tag that weighs just 60 milligrams and sells for $200. Researchers have tagged more than 400 monarchs this year and are now following their journeys on a cellphone app created by the New Jersey-based company that makes the tags, Cellular Tracking Technologies. Most monarchs weigh 500 to 600 milligrams, so each tag-bearing migrator making the transcontinental journey is, by weight, equivalent to a half-raisin carrying three uncooked grains of rice. Researchers are tracking more than 400 tagged monarch butterflies as they fly toward winter colonies in central Mexico. The maps [in the article] follow six butterflies. [...] Tracking the world's most famous insect migration may also have a big social impact, with monarch lovers able to follow the progress of individual butterflies on the free app, called Project Monarch Science. Many of the butterflies are flying over cities and suburbs where pollinator gardens are increasingly popular. Some tracks could even lead to the discovery of new winter hideaways. "There's nothing that's not amazing about this," said Cheryl Schultz, a butterfly scientist at Washington State University and the senior author of a recent study documenting a 22 percent drop in butterfly abundance in North America over a recent 20-year period. "Now we will have answers that could help us turn the tide for these bugs." Read more of this story at Slashdot.

alternative_right shares a report from ScienceAlert: A new study from researchers in Australia reveals that the people who never forget faces look "smarter, not harder." In other words, they naturally focus on a person's most distinguishing facial features. "Their skill isn't something you can learn like a trick," explains lead author James Dunn, a psychology researcher at the University of New South Wales (UNSW) Sydney. "It's an automatic, dynamic way of picking up what makes each face unique." To see what super-recognizers see, Dunn and his colleagues used eye-tracking technology to reconstruct how people surveyed new faces. They did this with 37 super-recognizers and 68 people with ordinary facial recognition skills, noting where and for how long participants looked at pictures of faces displayed on a computer screen. The researchers then fed the data into machine learning algorithms trained to recognize faces. The algorithms, a type known as deep neural networks, were tasked with deciding if two faces belonged to the same person. "These findings suggest that the perceptual foundations of individual differences in face recognition ability may originate at the earliest stages of visual processing -- at the level of retinal encoding," Dunn and colleagues write in their paper. The findings have been published in the journal Proceedings of the Royal Society B: Biological Sciences. Read more of this story at Slashdot.

For the first time, astronomers captured the shockwave of a supernova bursting through the surface of a dying red supergiant star, revealing a surprisingly symmetrical, grape-shaped explosion. Space.com reports: Seeing this moment in detail has previously been elusive because it's rare for a supernova to be spotted early enough and for telescopes to be trained on it -- and when they have been, the exploding star has been too far away. So, when supernova 2024ggi went boom on April 10, 2024 in the relatively nearby spiral galaxy NGC 3621, which is 22 million light-years away in the constellation of Hydra, the Water Snake, astronomer Yi Yang of Tsinghua University in Beijing knew he had to act. Although the supernova itself couldn't be resolved as anything put a point of light, the polarization of that light held the clues as to the geometry of the breakout. "The geometry of a supernova explosion provides fundamental information on stellar evolution and the physical processes leading to these cosmic fireworks," said Yang. "Spectropolarimetry delivers information about the geometry of the explosion that other types of observation cannot provide because the angular scales are too tiny," said another team-member, Lifan Wang of Texas A&M University. The measurement showed that the shape of the breakout explosion was flattened, like an olive or grape. Crucially, though, the explosion propagated symmetrically, and continued to do so even when it collided with a ring of circumstellar material. "These findings suggest a common physical mechanism that drives the explosion of many massive stars, which manifests a well-defined axial symmetry and acts on large scales," said Yang. The findings will allow astronomers to rule out some models and strengthen others that describe what drives the shockwave in a supernova explosion. The findings have been described in a paper on the ESO website. Read more of this story at Slashdot.

Should we leave space exploration to robots — or prioritize human spaceflight, making us a multiplanetary species? Harvard professor Robin Wordsworth, who's researched the evolution and habitability of terrestrial-type planets, shares his thoughts: In space, as on Earth, industrial structures degrade with time, and a truly sustainable life support system must have the capability to rebuild and recycle them. We've only partially solved this problem on Earth, which is why industrial civilization is currently causing serious environmental damage. There are no inherent physical limitations to life in the solar system beyond Earth — both elemental building blocks and energy from the sun are abundant — but technological society, which developed as an outgrowth of the biosphere, cannot yet exist independently of it. The challenge of building and maintaining robust life-support systems for humans beyond Earth is a key reason why a machine-dominated approach to space exploration is so appealing... However, it's notable that machines in space have not yet accomplished a basic task that biology performs continuously on Earth: acquiring raw materials and utilizing them for self-repair and growth. To many, this critical distinction is what separates living from non-living systems... The most advanced designs for self-assembling robots today begin with small subcomponents that must be manufactured separately beforehand. Overall, industrial technology remains Earth-centric in many important ways. Supply chains for electronic components are long and complex, and many raw materials are hard to source off-world... If we view the future expansion of life into space in a similar way as the emergence of complex life on land in the Paleozoic era, we can predict that new forms will emerge, shaped by their changed environment, while many historical characteristics will be preserved. For machine technology in the near term, evolution in a more life-like direction seems likely, with greater focus on regenerative parts and recycling, as well as increasingly sophisticated self-assembly capabilities. The inherent cost of transporting material out of Earth's gravity well will provide a particularly strong incentive for this to happen. If building space habitats is hard and machine technology is gradually developing more life-like capabilities, does this mean we humans might as well remain Earth-bound forever? This feels hard to accept because exploration is an intrinsic part of the human spirit... To me, the eventual extension of the entire biosphere beyond Earth, rather than either just robots or humans surrounded by mechanical life-support systems, seems like the most interesting and inspiring future possibility. Initially, this could take the form of enclosed habitats capable of supporting closed-loop ecosystems, on the moon, Mars or water-rich asteroids, in the mold of Biosphere 2. Habitats would be manufactured industrially or grown organically from locally available materials. Over time, technological advances and adaptation, whether natural or guided, would allow the spread of life to an increasingly wide range of locations in the solar system. The article ponders the benefits (and the history) of both approaches — with some fasincating insights along the way. "If genuine alien life is out there somewhere, we'll have a much better chance of comprehending it once we have direct experience of sustaining life beyond our home planet." Read more of this story at Slashdot.

A CRISPR-based drug given to study participants by infusion is raising hopes for a much easier way to lower cholesterol, reports CNN: With a snip of a gene, doctors may one day permanently lower dangerously high cholesterol, possibly removing the need for medication, according to a new pilot study published Saturday in the New England Journal of Medicine. The study was extremely small — only 15 patients with severe disease — and was meant to test the safety of a new medication delivered by CRISPR-Cas9, a biological sort of scissor which cuts a targeted gene to modify or turn it on or off. Preliminary results, however, showed nearly a 50% reduction in low-density lipoprotein, or LDL, the "bad" cholesterol which plays a major role in heart disease — the No.1 killer of adults in the United States and worldwide. The study, which will be presented Saturday at the American Heart Association Scientific Sessions in New Orleans, also found an average 55% reduction in triglycerides, a different type of fat in the blood that is also linked to an increased risk of cardiovascular disease. "We hope this is a permanent solution, where younger people with severe disease can undergo a 'one and done' gene therapy and have reduced LDL and triglycerides for the rest of their lives," said senior study author Dr. Steven Nissen, chief academic officer of the Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute at Cleveland Clinic in Ohio.... Today, cardiologists want people with existing heart disease or those born with a predisposition for hard-to-control cholesterol to lower their LDL well below 100, which is the average in the US, said Dr. Pradeep Natarajan, director of preventive cardiology at Massachusetts General Hospital and associate professor of medicine at Harvard Medical School in Boston... People with a nonfunctioning ANGPTL3 gene — which Natarajan says applies to about 1 in 250 people in the US — have lifelong levels of low LDL cholesterol and triglycerides without any apparent negative consequences. They also have exceedingly low or no risk for cardiovascular disease. "It's a naturally occurring mutation that's protective against cardiovascular disease," said Nissen, who holds the Lewis and Patricia Dickey Chair in Cardiovascular Medicine at Cleveland Clinic. "And now that CRISPR is here, we have the ability to change other people's genes so they too can have this protection." "Phase 2 clinical trials will begin soon, quickly followed by Phase 3 trials, which are designed to show the effect of the drug on a larger population, Nissen said." And CNN quotes Nissen as saying "We hope to do all this by the end of next year. We're moving very fast because this is a huge unmet medical need — millions of people have these disorders and many of them are not on treatment or have stopped treatment for whatever reason." Read more of this story at Slashdot.

The Associated Press reports that "For the past decade, Dr. Priscilla Chan and her husband Mark Zuckerberg have focused part of their philanthropy on a lofty goal — 'to cure, prevent or manage all disease' — if not in their lifetime, then in their children's." During that decade they also funded other initiatives (including underprivileged schools and immigration reform), according to the article. But there's a change coming: Now, the billionaire couple is shifting the bulk of their philanthropic resources to Biohub, the pair's science organization, and focusing on using artificial intelligence to accelerate scientific discovery. The idea is to develop virtual, AI-based cell models to understand how they work in the human body, study inflammation and use AI to "harness the immune system" for disease detection, prevention and treatment. "I feel like the science work that we've done, the Biohub model in particular, has been the most impactful thing that we have done. So we want to really double down on that. Biohub is going to be the main focus of our philanthropy going forward," Zuckerberg said Wednesday evening at an event at the Biohub Imaging Institute in Redwood City, California.... Chan and Zuckerberg have pledged 99% of their lifetime wealth — from shares of Meta Platforms, where Zuckerberg is CEO — toward these efforts... On Thursday, Chan and Zuckerberg also announced that Biohub has hired the team at EvolutionaryScale, an AI research lab that has created large-scale AI systems for the life sciences... Biohub's ambition for the next years and decades is to create virtual cell systems that would not have been possible without recent advances in AI. Similar to how large language models learn from vast databases of digital books, online writings and other media, its researchers and scientists are working toward building virtual systems that serve as digital representations of human physiology on all levels, such as molecular, cellular or genome. As it is open source — free and publicly available — scientists can then conduct virtual experiments on a scale not possible in physical laboratories. "We will continue the model we've pioneered of bringing together scientists and engineers in our own state-of-the-art labs to build tools that advance the field," according to Thursday's blog post. "We'll then use those tools to generate new data sets for training new biological AI models to create virtual cells and immune systems and engineer our cells to detect and treat disease.... "We have also established the first large-scale GPU cluster for biological research, as well as the largest datasets around human cell types. This collection of resources does not exist anywhere else." Read more of this story at Slashdot.

An Icelandic programmer successfully ran Doom on the European Space Agency's OPS-SAT satellite, proving that the iconic 1993 shooter can now run not just everywhere on Earth -- but in orbit. ZDNet reports: Olafur Waage, a senior software developer from Iceland who now works in Norway, explained at Ubuntu Summit 25.10 how he, a self-described "professional keyboard typist" and maker of funny videos, ended up making what is perhaps the game's most outlandish port yet: Doom running on a real satellite in orbit, the European Space Agency (ESA) OPS-SAT satellite. OPS-SAT, a "flying laboratory" for testing novel onboard computing techniques, was equipped with an experimental computer approximately 10 times more powerful than the norm for spacecraft. Waag explained, "OPS-SAT was the first of its kind, devoted to demonstrating drastically improved mission control capabilities when satellites can fly more powerful onboard computers. The point was to break the curse of being too risk-averse with multi-million-dollar spacecraft." (The satellite was decommissioned in 2024.) [...] Running Doom in orbit was partly a challenge of portability and partly a challenge of the limitations of space hardware and mission control. The on-board ARM dual-core Cortex-A9 processor, while hot stuff for space computing hardware (which tends to be low-powered and radiation-hardened), was slow even by Earth-bound standards. Waage chose Chocolate Doom 2.3, a popular open-source version of Doom, for its compatibility with the Ubuntu 18.04 Long Term Support (LTS) distro, which was already running on OPS-SAT. Besides, Waage noted, "We picked Chocolate Doom 2.3 because of the libraries available for 18.04 -- that was the last one that would actually build. Updating software in orbit is extremely difficult, so relatively little code would have to be uploaded. As Waage said, "Doom is relatively straightforward C with a few external dependencies." In other words, it's easy to port. [...] The only sign that Doom was running in space at first was a lone log entry. So, the team used the satellite's camera to snap real-time images of the Earth, then swapped Doom's Mars skybox for actual satellite photos. "The idea was to take a screenshot from the satellite and use that as the sky, all rendered in software using the game's restricted 256-color palette," explained Waage. Even this posed unexpected difficulties: "Trying to draw all of these beautiful colors with those colors," said Waage, "it's probably not going to work right off. But we tried gradient tests, NASA demo photos. It took quite a bit of tweaking." Eventually, instead of a fantasy Mars as the sky background, they got a good-looking, real Earth in the game's sky. The game itself ran flawlessly. After all, Waage said, "It ran beautifully. It's on Ubuntu." Read more of this story at Slashdot.

Airbus, Leonardo, and Thales are merging their space divisions into a new France-based company that aims to create a "leading European player in space." The joint venture, expected to launch operations by 2027 pending regulatory approval, will pool R&D resources to accelerate satellite development and strengthen Europe's technological sovereignty in space. Engadget reports: The companies Airbus, Leonardo and Thales have finalized this deal. The new unnamed entity will be based in France and will employ around 25,000 people. Airbus will own 35 percent, while the other two companies will each own 32.5 percent. Executives are hoping this company will better serve Europe's need for "sovereignty" in space and help it create a rival to SpaceX's Starlink communications network. Increasing a presence in space is also seen as a good thing for security and defense. This isn't just bluster. Thales and Airbus have long been rivals in the satellite market, but it looks like they are friends now. Leonardo is known for space systems and services. Combining all three could actually give SpaceX a run for its money, but we will have to wait and see. There are no planned site closures, as the companies say that each home country will keep its existing capabilities. This will be a standalone company, so think of it as an extremely well-financed startup. The first task for the upstart? Reporting indicates it'll be to find more efficient ways to develop and manufacture satellites. Read more of this story at Slashdot.

A study involving 641 participants across 10 European countries found pesticides in every silicone wristband worn for one week. Researchers at Radboud University tested for 193 pesticides and detected 173 substances. The average participant was exposed to 20 different pesticides through non-dietary sources. Non-organic farmers had the highest exposure at a median of 36 pesticides. Organic farmers and people living near farms recorded lower numbers. Consumers living far from agricultural areas had a median of 17 pesticides. The wristbands captured banned substances including breakdown products of DDT, which was prohibited decades ago, and insecticides dieldrin and propoxur. Paul Scheepers, the molecular epidemiologist who co-authored the study, said people cannot avoid exposure to pesticides in their direct environment. Read more of this story at Slashdot.

China's private space company LandSpace has completed a key static fire test of its Zhuque-3 (ZQ-3) reusable rocket -- a stainless-steel, methane-fueled launcher modeled after SpaceX's Starship. Universe Today reports: The latest milestone took place on Monday, Oct. 22nd at the Dongfeng commercial space innovation pilot zone (where the JSLC is located). It involved another static fire test, where the rocket was fully-fueled but remained fixed to the launch pad while the engines were fired. This kind of testing is a crucial prelaunch trial (what NASA refers to as a "wet dress rehearsal"), and places the company and China another step closer to making an inaugural flight test, which is expected to happen by the fourth quarter of 2025. In traditional Chinese, Zhuque is the name of the Vermillion Bird that represents fire, the south, and summer, and is one of the four Symbols of the Chinese constellations. Like the Starship, the Zhuque-3 is composed of stainless steel and relies on a combination of liquid methane (LCH4) and liquid oxygen (LOX) propellant. The rocket will be powered by nine Tianque-12A (TQ-12A) engines and will measure 65.9 m (216 ft) tall and weigh 550,000 kg (1,210,000 lb). It's payload capacity will be significantly less than the Starship: 11,800 kg (26,000 lbs) in its expendable mode, and 8,000 kg (18,000 lbs) for the recoverable version. This is closer in payload capacity to the Falcon 9, which is capable of delivering 22,800 kg (50,265 lbs) to Low Earth Orbit (LEO). In time, the company hopes to transition to the larger Zhuque-3E, which will be 76.2 m (250 ft) tall and powered by nine TQ-12B engines, and will be capable of delivering to 21,000 kg (46,000 lb) in its expandable mode and 18,300 kg (40,300 lb) recoverable. The long term goal is to create a reusable system that can rival the Falcon rocket family, bringing the country closer to its goal of achieving parity with NASA. Read more of this story at Slashdot.

"Japan's new HTV-X cargo spacecraft launched on its first-ever mission to the International Space Station on Saturday," reports Space.com: The robotic HTV-X lifted off atop an H3 rocket from Japan's Tanegashima Space Center at 8 p.m. EDT (0000 GMT and 9 a.m local Japan time on October 26). It is expected to arrive at the station for its capture and berthing on Wednesday (Oct. 29) at about 11:50 a.m. EDT (1550 GMT)... The HTV-X's potential uses also extend beyond the ISS, according to JAXA. The agency envisions it aiding "post-ISS human space activities in low Earth orbit" as well as possibly flying cargo to Gateway, the space station NASA may build in lunar orbit as part of its Artemis program. HTV-X's debut increases the stable of ISS cargo craft by one-third. The currently operational freighters are Russia's Progress vehicle and Cygnus and Dragon, spacecraft built by the American companies Northrop Grumman and SpaceX, respectively. Only Dragon is reusable; the others (including HTV-X) are designed to burn up in Earth's atmosphere when their missions are over. Read more of this story at Slashdot.