Schwalbe Lab
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schwalbe-lab.bsky.social
Schwalbe Lab
@schwalbe-lab.bsky.social
NMR spectroscopy on nucleic acids and proteins based at Goethe-University Frankfurt, Germany.
This account is run by the members of the Schwalbe lab.

https://schwalbe-lab.de/

#nmr #biomolecules #rna #proteins #dna #drugtargeting #interactions

Reposted by Schwalbe Lab
Lucia Banci, Instruct-IT, and Harald Schwalbe visit the new Instruct-DE research side at TU Munich.
Lucia covers the technological developments in drug screening by in-cell NMR, supported by Fragment-Screen

fragmentscreen.org @schwalbe-lab.bsky.social @cerm-cirmmp.bsky.social @tumunich.bsky.social
November 7, 2025 at 10:39 AM
Reposted by Schwalbe Lab
At this years German User Meeting of Bruker, Instruct Director Prof. Harald Schwalbe introduced the Access options in Instruct for structural biology to more than 200 NMR Scientists, including many facility managers from Germany, Austria and Switzerland - instruct-eric.org @schwalbe-lab.bsky.social
November 5, 2025 at 11:15 AM
Have a look into our newest publication showing how GS-441524 derivatives can potently inhibit the SARS-CoV-2 macrodomain (Nsp3b), offering a structural roadmap for next-generation antiviral design.

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

#SARSCoV2 #NMR #drugtargeting #synthesis
Structure‐Based Rational Design of a Selective Hydrolase Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus‐2 Nsp3 Macrodomain
Structure-guided design of a sulfamoyl-modified analog of GS-441524 yielded a selective, high-affinity inhibitor of the SARS-CoV-2 macrodomain Nsp3b. The compound occupies the phosphate-binding pocke...
chemistry-europe.onlinelibrary.wiley.com
November 3, 2025 at 12:12 PM
Reposted by Schwalbe Lab
Prof. Harald Schwalbe presenting Fragment-based Drug Discovery at at the 25th ChemBioChem Symposium!

Prof. Schwalbe is coordinator of the Fragment-Screen project, developing new tools for fragment-based drug discovery

Find out more here - fragmentscreen.org/home @schwalbe-lab.bsky.social
October 24, 2025 at 12:02 PM
Great news: Harald Schwalbe has been reappointed as Director of Instruct-ERIC, extending his term through Dec 2031. His leadership shows strong confidence in his work advancing structural biology and research collaboration across Europe. @instruct-eric.bsky.social
instruct-eric.org/news/profess...
Professor Harald Schwalbe Renewed as Instruct-ERIC Director
Instruct-ERIC is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to all European researchers.
instruct-eric.org
October 23, 2025 at 7:55 AM
Our study shows Ephrin A1 undergoes conformational selection when binding EphA2, while its juxtamembrane regions stay flexible. These insights clarify bidirectional signaling and may guide future therapeutic strategies.
Full text: www.sciencedirect.com/science/arti...

#NMR #Ephrin #Cancer #receptor
Structural role of conformational heterogeneity and juxtamembrane regions in the Ephrin A1 interactions with the EphA2 receptor ligand-binding domain
Ephrin growth factors are attached to the membrane by either GPI-anchor or transmembrane domains and are known to signal bi-directionally: cells, expr…
www.sciencedirect.com
September 29, 2025 at 8:47 AM
Great contribution from our former lab member Robert Silvers in @narjournal.bsky.social ☺️
"Noncanonical RNA binding of human La-related protein 6"
Full text: academic.oup.com/nar/article/...
#LARP #NMR #RNA #structure
Noncanonical RNA binding of human La-related protein 6
Abstract. La-related proteins (LARPs) are RNA-binding proteins that are involved in a variety of disease-related processes. Most LARPs recognize short sing
academic.oup.com
September 25, 2025 at 8:32 AM
Take a look at the publication of our former lab member Nina Kubatova in @pnas.org 😇
"Dimerization propensity of the β1-adrenergic receptor in lipid nanodiscs probed by DEER and single-molecule spectroscopies"
Full text: www.pnas.org/doi/10.1073/...
#DEER #protein #SingleMolecule #GPCR
Dimerization propensity of the β1-adrenergic receptor in lipid nanodiscs probed by DEER and single-molecule spectroscopies | PNAS
G protein–coupled receptors (GPCRs) comprise a large class of membrane proteins that mediate cellular responses to a wide range of external signals...
www.pnas.org
September 25, 2025 at 8:27 AM
Together with the Evanseck Lab, our lab just published the NMR + MD structure of the Omicron SARS-CoV-2 s2m RNA, revealing a pentaloop with remarkable dynamics.

Full text: m.rnajournal.cshlp.org/content/earl...

#NMR #MD #RNA #SARSCoV2 #structure #dynamics
RNA | Mobile
m.rnajournal.cshlp.org
September 23, 2025 at 11:24 AM
At the 2025 meeting of the German focus group of Magnetic Resonance (FGMR, EPR/NMR), Harald Schwalbe, Instruct-director, introduced access possibilities and highlighted the recent installation of the German Instruct centre.

@instruct-eric.bsky.social @gdch.de

#NMR #EPR #FGMR #GDCh #InstructERIC
September 16, 2025 at 1:32 PM
Exciting work from Duchardt-Ferner et al. in NAR: high-res. NMR structure of a tobramycin-responsive riboswitch. Shows a novel aminoglycoside-binding RNA motif with unique RNA-RNA contacts, explaining its exceptional switching efficiency in eukaryotic translation.
academic.oup.com/nar/article/...
Structural basis for ligand recognition in the tobramycin riboswitch
Abstract. Recently, a novel tobramycin-responsive riboswitch was developed by a combination of Capture-SELEX and in vivo screening. This riboswitch regulat
academic.oup.com
September 8, 2025 at 3:14 PM
Reposted by Schwalbe Lab
Instruct Director Harald Schwalbe will be in Denmark for the SBiNLab’s 25th anniversary!

www1.bio.ku.dk/english/rese... @schwalbe-lab.bsky.social

Researchers in Denmark can receive access to Instruct technologies and instrumentation here - instruct-eric.org/submit-propo...
New Horizons in Protein Dynamics – Department of Biology - University of Copenhagen
www1.bio.ku.dk
August 22, 2025 at 3:22 PM
Our newest publication is online!
Using fragment-growth guided by NMR spectroscopy, we optimized small molecules targeting SCoV-2 SL1 RNA, integrating solubility, affinity, and specificity to identify translation inhibitors.

Full text: pubs.acs.org/doi/10.1021/...

#NMR #drugdesign #RNA #SARSCoV2
Targeting the SARS-CoV-2 RNA Translation Initiation Element SL1 by Molecules of Low Molecular Weight
We present the development of low molecular weight inhibitors that target the 5′-terminal RNA stem-loop 1 (SL1) of the SARS-CoV-2 genome. SL1 is crucial for allowing viral protein synthesis in the con...
pubs.acs.org
August 5, 2025 at 6:45 AM
Check out our newest chemical shift assignment! 🎉
We used NMR to characterize the SL5a stem-loop from HCoV-229E, a conserved RNA element key to coronavirus RNA translation and replication.

doi.org/10.1007/s121...

#RNA #NMR #Virology #StructuralBiology #Assignment #Coronavirus
1H, 13C and 15N chemical shift assignment for stem-loop 5a from the 5‘UTR of HCoV-229E - Biomolecular NMR Assignments
Due to the emergence of the SARS-CoV-2 virus, research on coronaviruses has been massively accelerated. In addition to SARS-CoV-2, there are other human coronaviruses, including HCoV-229E. In all coro...
doi.org
July 31, 2025 at 7:03 AM
Reposted by Schwalbe Lab
RT @euromar2025 EUROMAR 2025 opens in Oulu
A fantastic lineup of prize winners:
🏆 Prof. Thomas Prisner – Richard R. Ernst Prize
🏆 Dr. Nergiz Sahin Solmaz – Raymond Andrew Prize
🏆 Prof. Tuo Wang – Ampere Prize for Young Investigators

Congratulations to all!
#EUROMAR2025 #NMR #EPR #MRI #ESR #NMRchat
July 6, 2025 at 5:47 PM
Workshop Alert: On July 10, Nathalie Weickgenannt and Laura Buglioni from @angewandtechemie.bsky.social will be at Goethe University Frankfurt to host a Wiley Publishing Workshop. Don’t miss this opportunity to gain valuable insights into scientific publishing!
July 3, 2025 at 9:03 PM
New publication is out in @febsopenbio.bsky.social ! 🎉
"NMR screening of low molecular weight inhibitors targeting the papain-like protease (PLPro) of SARS-CoV-2"

Full text: febs.onlinelibrary.wiley.com/doi/10.1002/...

#screening #NMR #SARS-CoV2 #targeting
FEBS Press
Papain-like protease from SARS-CoV-2 plays an important role in the cleavage of the viral polyproteins and in the suppression of the host's immune response. Here, we present the results of an NMR scr...
febs.onlinelibrary.wiley.com
July 2, 2025 at 10:19 AM
New publication in @narjournal.bsky.social - Using NMR, SAXS & MD, we characterize the dynamic nonaloop of the SARS-CoV-2 Delta s2m RNA, contributing to future ensemble-functional studies of dynamic RNA motifs.

Full text: doi.org/10.1093/nar/...

#RNA #StructuralBiology #NAR #NMR #MDSimulations
Structural heterogeneity and dynamics in the apical stem loop of s2m from SARS-CoV-2 Delta by an integrative NMR spectroscopy and MD simulation approach
Abstract. In structured RNAs, helical elements are often capped by apical loops that are integral structural elements, ranging from 3 to >20 nts of size
doi.org
July 1, 2025 at 6:57 AM
Let's support the Bethesda Declaration and stand up for science together ✍️
actionnetwork.org/petitions/op...
Sign The Open Letter to Stand Up For Science Now!
Science is under siege. Trump’s latest Executive Order calls for politically appointed science commissars to evaluate research. Join us in adding your name to our open letter condemning Trump’s escala...
actionnetwork.org
June 10, 2025 at 1:04 PM
A great overview of methods to investigate RNA modifications 😊
onlinelibrary.wiley.com/doi/full/10....
May 30, 2025 at 8:57 AM
Prof. José María Carazo has been elected Chair of the Instruct-ERIC Council, with Dr. Evangelia Chrysina as Vice-Chair. Both bring structural biology expertise to further develop European research infrastructure.

@instruct-eric.bsky.social

instruct-eric.org/news/instruc...
Instruct-ERIC New Council Chair and Vice-Chair
Instruct-ERIC is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to all European researchers.
instruct-eric.org
May 26, 2025 at 7:01 AM
Another publication on DNA G-quadruplexes in collaboration with the Heckel group is out! 🎉

"Structural Insights into Spare-Tire DNA G-Quadruplex from the Human VEGF Promoter"

Full text: pubs.acs.org/doi/10.1021/...

#G4 #quadruplex #photocages #NMR #VEGF #structure
Structural Insights into Spare-Tire DNA G-Quadruplex from the Human VEGF Promoter
The vascular endothelial growth factor (VEGF) promoter region, which is involved in cancer progression, contains guanine-rich sequences capable of forming G-quadruplex (G4) structures. G4s play a crit...
pubs.acs.org
May 16, 2025 at 10:50 AM
New publication from Robert Silver's lab reporting the NMR assignment of the 5'SL-bound La domain of human La-related protein 6 (HsLARP6). Congratulations!

Full text:
link.springer.com/article/10.1...
1H, 13C, and 15N resonance assignment of the 5’SL-bound La domain of the human La-related protein 6 - Biomolecular NMR Assignments
Human La-related protein 6 (HsLARP6) participates in the post-transcriptional regulation of type I collagen biosynthesis and is involved in the onset and progression of fibroproliferative disease. The...
link.springer.com
May 5, 2025 at 8:18 AM