Key finding is that chromatin sensitivity is not binary, but a continuum across TFs, clearly arguing against a purely hierarchical model involving chromatin-insensitive TFs (pioneers) that open the chromatin for other chromatin-sensitive TFs to bind.

Demonstrates how a combination of opportunistic binding and context-specific chromatin-opening underpin TF specificity, driving differentiation trajectories.

Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....