Schirmer Lab
@schirmer-lab.bsky.social
I'm a professor for Translational Microbiome Data Integration at the Technical University of Munich. My lab works on host-microbial interactions.
1/3 Second preprint: Gene-centric metagenomic framework for efficient, scalable analyses of cohort data. We built a >33M gene-family resource across 24 cohorts combined with a cohort-scale assembly-graph (MAGraph) to recover gene neighborhoods. Read more: www.biorxiv.org/content/10.1...
Gene-centric metagenomic analyses reveal microbiome functional insights into diseases
The microbiome encodes millions of genes; however, understanding their role in human health remains challenging. Here, we developed MetaGEAR, a gene-centric analysis framework for metagenomic data. Me...
www.biorxiv.org
October 20, 2025 at 11:53 AM
1/3 Second preprint: Gene-centric metagenomic framework for efficient, scalable analyses of cohort data. We built a >33M gene-family resource across 24 cohorts combined with a cohort-scale assembly-graph (MAGraph) to recover gene neighborhoods. Read more: www.biorxiv.org/content/10.1...
1/2 New preprint: Oral→gut translocation in advanced chronic liver disease shows links to gut-barrier dysfunction and hepatic fibrosis. Thanks to the team & collaborators at KCH and Quadram. Preprint link: www.biorxiv.org/content/10.1...
Microbial oral-gut translocation in advanced chronic liver disease is linked to exacerbation of intestinal barrier dysfunction and hepatic fibrosis
While microbiome perturbations are associated with advanced chronic liver disease (ACLD), microbial disease mechanisms are poorly understood. Using multi-omics analyses of paired saliva and faecal sam...
www.biorxiv.org
October 20, 2025 at 11:38 AM
1/2 New preprint: Oral→gut translocation in advanced chronic liver disease shows links to gut-barrier dysfunction and hepatic fibrosis. Thanks to the team & collaborators at KCH and Quadram. Preprint link: www.biorxiv.org/content/10.1...
We are excited to announce the release of MetaGEAR, a platform for exploring microbial gene functions in gastrointestinal diseases. #MetaGEAR integrates #metagenomic data from over 9K human samples, streamlining the identification of microbial genes linked to IDB and CRC: www.mls.ls.tum.de/mdi/tools
April 23, 2025 at 3:23 PM
We are excited to announce the release of MetaGEAR, a platform for exploring microbial gene functions in gastrointestinal diseases. #MetaGEAR integrates #metagenomic data from over 9K human samples, streamlining the identification of microbial genes linked to IDB and CRC: www.mls.ls.tum.de/mdi/tools