SattelyLab
@sattelylab.bsky.social
Website: https://www.sattelylab.org/
Member-run account of the Elizabeth Sattely Lab at Stanford University
Plant natural products | Plant-microbe interactions | Plant chemistry | Pathway discovery | Plant health | Plant-human interactions
Member-run account of the Elizabeth Sattely Lab at Stanford University
Plant natural products | Plant-microbe interactions | Plant chemistry | Pathway discovery | Plant health | Plant-human interactions
We are live!
Check out our new website and learn about the research, the people, and the publications of the Sattely Lab www.sattelylab.org
Check out our new website and learn about the research, the people, and the publications of the Sattely Lab www.sattelylab.org
Sattely Research Group @ Stanford
Explore plant chemistry research at Sattely Group, focusing on plant chemistry for agriculture and human health innovations.
www.sattelylab.org
November 3, 2025 at 8:46 PM
We are live!
Check out our new website and learn about the research, the people, and the publications of the Sattely Lab www.sattelylab.org
Check out our new website and learn about the research, the people, and the publications of the Sattely Lab www.sattelylab.org
Reposted by SattelyLab
Thanks to Dr. Cassandra Quave for hosting me on her Foodie Pharmacology podcast!
We discussed the molecules responsible for the properties of medicinal plants - and how my lab studies the chemistry that plants use to make them. Check it out!
t.co/nEdpoyN8QD
We discussed the molecules responsible for the properties of medicinal plants - and how my lab studies the chemistry that plants use to make them. Check it out!
t.co/nEdpoyN8QD
September 15, 2025 at 7:34 PM
Thanks to Dr. Cassandra Quave for hosting me on her Foodie Pharmacology podcast!
We discussed the molecules responsible for the properties of medicinal plants - and how my lab studies the chemistry that plants use to make them. Check it out!
t.co/nEdpoyN8QD
We discussed the molecules responsible for the properties of medicinal plants - and how my lab studies the chemistry that plants use to make them. Check it out!
t.co/nEdpoyN8QD
Beautiful work by Yaereen and former lab member Kevin! Learn more about the anti-cancer compound homoharringtonine and its'biosynthesis in plants here 🌿https://www.biorxiv.org/content/10.1101/2025.08.26.672243v1
Discovery of homoharringtonine pathway enzymes reveals a whole plant model for coordinated biosynthesis
Plants have evolved to produce diverse molecules that inhibit protein translation. A lead example is homoharringtonine (HHT), both a key tool for ribosomal profiling and an FDA-approved treatment for ...
www.biorxiv.org
September 2, 2025 at 10:13 PM
Beautiful work by Yaereen and former lab member Kevin! Learn more about the anti-cancer compound homoharringtonine and its'biosynthesis in plants here 🌿https://www.biorxiv.org/content/10.1101/2025.08.26.672243v1
Congrats Guillermo! Fantastic finish to his ChemE REU program participation
August 29, 2025 at 5:01 PM
Congrats Guillermo! Fantastic finish to his ChemE REU program participation
Congrats, Jack, for a successful PhD defense🎉Party, T-shirt exchange, and a self-made Piñata
August 22, 2025 at 8:49 PM
Congrats, Jack, for a successful PhD defense🎉Party, T-shirt exchange, and a self-made Piñata
Most recent group photos! So many celebrations🥳
August 21, 2025 at 10:07 PM
Most recent group photos! So many celebrations🥳
Couldn't have said it better! Great job @taralowensohn.bsky.social, Will, and Chun! Special thanks to the Gao lab at @stanford.edu #singlecell #plantbiology
A truly enabling new approach by @taralowensohn.bsky.social Will Cody and @sattelylab.bsky.social to probe plant genetics at scale.
Single-gene-per-cell delivery coupled to an effective transcriptional selection system
www.biorxiv.org/content/10.1...
Single-gene-per-cell delivery coupled to an effective transcriptional selection system
www.biorxiv.org/content/10.1...
August 7, 2025 at 10:37 PM
Couldn't have said it better! Great job @taralowensohn.bsky.social, Will, and Chun! Special thanks to the Gao lab at @stanford.edu #singlecell #plantbiology
@cmcclune.bsky.social will be at the GRC for Single-Cell Approaches in Plant Biology! Be on the lookout for his talk on Wednesday (8/13) at 9.10 am. Talk will be about some new approaches and discoveries recently published in Nature! www.nature.com/articles/s41... #grc #singlecell #plantbiology
Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature
An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...
www.nature.com
August 7, 2025 at 5:44 PM
@cmcclune.bsky.social will be at the GRC for Single-Cell Approaches in Plant Biology! Be on the lookout for his talk on Wednesday (8/13) at 9.10 am. Talk will be about some new approaches and discoveries recently published in Nature! www.nature.com/articles/s41... #grc #singlecell #plantbiology
Watch out for @taralowensohn.bsky.social at the GRC for Single-Cell Approaches in Plant Biology. She will be giving a talk about the pooled gene perturbation and protoplast sorting technologies developed in the lab. Interested? Talk on Monday at 8.10 pm. #grc #singlecell #plants #plantbiology
August 7, 2025 at 5:39 PM
Watch out for @taralowensohn.bsky.social at the GRC for Single-Cell Approaches in Plant Biology. She will be giving a talk about the pooled gene perturbation and protoplast sorting technologies developed in the lab. Interested? Talk on Monday at 8.10 pm. #grc #singlecell #plants #plantbiology
Reposted by SattelyLab
The Blum lab is recruiting graduate students and postdocs! Grad students: Reach out to me if you're interested in a rotation! Postdoc candidates: recruiting2.ultipro.com/SAL1013SIBS/...
recruiting2.ultipro.com
July 23, 2025 at 2:43 AM
The Blum lab is recruiting graduate students and postdocs! Grad students: Reach out to me if you're interested in a rotation! Postdoc candidates: recruiting2.ultipro.com/SAL1013SIBS/...
Congrats!
Extremely happy to see our withanolide biosynthesis paper out in @natcomms.nature.com rdcu.be/evHOF
Fantastic team effort with the Pucker group @bpucker.bsky.social @puckerlab.bsky.social at @unibonn.bsky.social and Heretsch, Herde and Witte groups at @unihannover.bsky.social. Funded by @dfg.de
Fantastic team effort with the Pucker group @bpucker.bsky.social @puckerlab.bsky.social at @unibonn.bsky.social and Heretsch, Herde and Witte groups at @unihannover.bsky.social. Funded by @dfg.de
Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis
Nature Communications - Withanolides are plant steroids with potent bioactivities found in many medicinal plants including Withania somnifera, but their biosynthetic pathway is largely unknown....
rdcu.be
July 10, 2025 at 10:26 PM
Congrats!
Reposted by SattelyLab
Plant Science Research Weekly -- Elucidation and recreation of the biosynthetic pathway for taxol (Nature) @cmcclune.bsky.social (Summary by Mary Williams @PlantTeaching.bsky.social)
buff.ly/miccEK3
#PlantaePSRW
buff.ly/miccEK3
#PlantaePSRW
Elucidation and recreation of the biosynthetic pathway for taxol | Plantae
Paclitaxel (sold as Taxol) is taxane diterpene natural product of yew trees (Taxus spp.) and a potent stabilizer of microtubules that is effective in treatment of cancers. However…
buff.ly
July 2, 2025 at 4:46 PM
Reposted by SattelyLab
Great article in today’s Stanford Report on our recent work deciphering how yew trees produce Taxol
@sattelylab.bsky.social news.stanford.edu/stories/2025...
@sattelylab.bsky.social news.stanford.edu/stories/2025...
New insights in plant gene research could boost cancer drug production
A novel approach to analyzing yew tree genes has revealed key enzymes used to make Taxol, a chemotherapy drug that’s long been difficult and costly to produce.
news.stanford.edu
June 25, 2025 at 12:32 AM
Great article in today’s Stanford Report on our recent work deciphering how yew trees produce Taxol
@sattelylab.bsky.social news.stanford.edu/stories/2025...
@sattelylab.bsky.social news.stanford.edu/stories/2025...
Fresh off the press! Check out the newest paper from the Sattely lab and @pollyfordyce.bsky.social lab! Spearheaded by @cmcclune.bsky.social #plants #plantbiology #anticancer #drug #taxol
Today in Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III & deBz-deoxy-Taxol #SingleCell #secmet 🧬🧪🌾
Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature
An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...
www.nature.com
June 11, 2025 at 8:22 PM
Fresh off the press! Check out the newest paper from the Sattely lab and @pollyfordyce.bsky.social lab! Spearheaded by @cmcclune.bsky.social #plants #plantbiology #anticancer #drug #taxol
Thanks to Jakob Franke for highlighting the Taxol/FoTO1 gene discovery and the mpXsn approach spearheaded by @cmcclune.bsky.social in @nature.com! Check it out here: www.nature.com/articles/d41... #plants #anti-cancer #singlecell #plantbiology
Biochemical breakthrough paves way to reliable supply of anticancer drug
‘Missing’ genes needed for the biosynthesis of a natural anticancer drug have been discovered by perturbing and analysing individual cells of yew trees.
www.nature.com
June 11, 2025 at 6:03 PM
Thanks to Jakob Franke for highlighting the Taxol/FoTO1 gene discovery and the mpXsn approach spearheaded by @cmcclune.bsky.social in @nature.com! Check it out here: www.nature.com/articles/d41... #plants #anti-cancer #singlecell #plantbiology
Preprint for the exciting, upcoming Nature paper! @cmcclune.bsky.social, Jack, Chloe, and Ricardo from the Sattely lab (in collaboration with @pollyfordyce.bsky.social) discovered genes for the anti-cancer drug Taxol pathway - plus a gene boosting the production of a bottleneck intermediate!
Our Taxol pathway preprint!
We developed a systematic strategy to activate and identify gene sets in plants. Used it to identify 8 genes in the Taxol pathway, enabling a 20-gene biosynthesis of a Taxol precursor.
Biggest surprise: a new protein that helps our oxidases produce the correct product
We developed a systematic strategy to activate and identify gene sets in plants. Used it to identify 8 genes in the Taxol pathway, enabling a 20-gene biosynthesis of a Taxol precursor.
Biggest surprise: a new protein that helps our oxidases produce the correct product
Multiplexed perturbation of yew reveals cryptic proteins that enable a total biosynthesis of baccatin III and Taxol precursors
Plants make complex and potent therapeutic molecules, but difficulties in sourcing from natural producers or chemical synthesis can challenge their use in the clinic. A prominent example is the anti-c...
www.biorxiv.org
June 11, 2025 at 5:56 PM
Preprint for the exciting, upcoming Nature paper! @cmcclune.bsky.social, Jack, Chloe, and Ricardo from the Sattely lab (in collaboration with @pollyfordyce.bsky.social) discovered genes for the anti-cancer drug Taxol pathway - plus a gene boosting the production of a bottleneck intermediate!
Congrats @caseyvchan.bsky.social to a successful Qual exam!!!😀
April 28, 2025 at 4:18 PM
Congrats @caseyvchan.bsky.social to a successful Qual exam!!!😀
The 1st Annual Bay Area Plant Hub recently concluded, and it was a resounding success! We thoroughly enjoyed connecting with everyone. Hope you had a chance to stop by @caseyvchan.bsky.social 's and @taralowensohn.bsky.social 's posters. Plus listen to an intriguing discussion with Beth and others 🌱
April 17, 2025 at 10:39 PM
The 1st Annual Bay Area Plant Hub recently concluded, and it was a resounding success! We thoroughly enjoyed connecting with everyone. Hope you had a chance to stop by @caseyvchan.bsky.social 's and @taralowensohn.bsky.social 's posters. Plus listen to an intriguing discussion with Beth and others 🌱
Reposted by SattelyLab
🌱 Elizabeth Sattely, Stanford Chemical Engineering professor, explores how plants turn CO2 & sunlight into molecules that boost resilience & human health. Her work aims to create crops resilient to climate change & disease, improving global food systems. #SustainableAgriculture 🌍🍃
March 18, 2025 at 12:12 AM
🌱 Elizabeth Sattely, Stanford Chemical Engineering professor, explores how plants turn CO2 & sunlight into molecules that boost resilience & human health. Her work aims to create crops resilient to climate change & disease, improving global food systems. #SustainableAgriculture 🌍🍃