💡 A: In stable FN patients with persistent fever of unknown origin, current NCCN and ECIL guidelines do not recommend changing empiric coverage for Gram-negative bacteria.

⏳ Time to defervescence may last 2-7 days (median of 5 days) for patients on appropriate initial antibiotic therapy. (3)

#brucella #PEP 2 effective abx should be given: Doxycycline 100mg bid + Rifampin 600mg daily x 3 wks
-If cant use either doxy or rif: use tmp-smx
-Weekly sx check through 24 weeks post exposure
-serology at 0,6,12,18,24 weeks #idsky