🔗 To learn more about #DeZI:
www.imperial.ac.uk/news/269973/...

🌍 #DeZi Partners span research institutions and public-health laboratories in more than 15 countries across #Africa, #Asia, and #LatinAmerica, working closely with UKHSA, Yale University, @who.int , and networks such as #UNITEDengue, #CREID, and #ARTIC2.0.

With its #open-access resources and policy engagement activities #DeZi will help countries integrate the surveillance of dengue, Zika, and other #mosquito-borne #viruses into routine national health systems, turning collaboration into capacity, and data into effective policymaking.

By combining innovation with equitable partnerships, #DeZi aims to:
• accelerate the adoption of improved diagnostics
• strengthen regional laboratory capacity and South–South collaborations
• enhance preparedness for future #arboviral #epidemics in a changing climate

🔬 #DeZi in brief:
Global initiative led by Imperial College London & Nuno R. Faria, supported by the #WellcomeTrust, Temasek Foundation & the National Environment Agency
It integrates #genomics, #serology & #modelling to map the burden, transmission, and evolution of dengue and Zika viruses.

Love seeing this! and couldn’t help but smile spotting my 2 posters quietly photobombing in the back! ☺️

These findings suggest that certain ZIKV-cross-reactive anti-DENV antibodies, especially those capable of activating complement, may help reduce the risk of severe dengue.

Among the different antibody features we analyzed, complement-dependent virolysis using ZIKV virions stood out as the strongest correlate of protection against severe outcomes, including thrombocytopenia and plasma leakage.

We analyzed pre-infection plasma from Nicaraguan children who went on to develop either dengue fever or severe dengue (DHF/DSS) upon secondary DENV infection.