Sandhya Manohar
banner
sandhya-manohar.bsky.social
Sandhya Manohar
@sandhya-manohar.bsky.social
SNSF Ambizione group leader studying why big cells break bad | here for cell cycle regulation, DNA damage signaling, and distance running | she/her
Reposted by Sandhya Manohar
🚨 Paper alert! 🚨 After >1 year in review and six (6!) reviewers, I'm thrilled that this paper is finally out! Here, we provide the first data-based record of marine dissolved organic carbon in the geologic past.
www.nature.com/articles/s41...
The geologic history of marine dissolved organic carbon from iron oxides - Nature
A direct proxy for past dissolved organic carbon signatures using co-precipitated organic carbon in iron ooids enables reconstruction of marine dissolved organic carbon signals dating back to the Pala...
www.nature.com
August 13, 2025 at 4:11 PM
Hello 7 followers! Ever wonder why cells of the same type tend to have a pretty uniform size? Check out our new paper out in @MolecularCell today to find out why too big can be a bad thing in terms of genome homeostasis and proliferative potential.

www.cell.com/molecular-ce...
Genome homeostasis defects drive enlarged cells into senescence
Manohar et al. studied how increased cell size—a hallmark of senescence—impairs long-term proliferation. Excess cell size activates p53-p21 signaling and impairs 53BP1 recruitment to DNA double-s...
www.cell.com
November 16, 2023 at 5:17 PM