Samuel 🏳️🌈
@samugab.bsky.social
Reposted by Samuel 🏳️🌈
H5N1. A pandemic resembles cigarette smoke: it enters as blue and exits as gray.
(mega-thread🧵)
To my friends on X and BlueSky who believe, the initial warning signs of H5N1 indicate a looming pandemic, I’d like to share the latest 13 studies posted in the past two months.
(mega-thread🧵)
To my friends on X and BlueSky who believe, the initial warning signs of H5N1 indicate a looming pandemic, I’d like to share the latest 13 studies posted in the past two months.
November 17, 2024 at 5:39 PM
H5N1. A pandemic resembles cigarette smoke: it enters as blue and exits as gray.
(mega-thread🧵)
To my friends on X and BlueSky who believe, the initial warning signs of H5N1 indicate a looming pandemic, I’d like to share the latest 13 studies posted in the past two months.
(mega-thread🧵)
To my friends on X and BlueSky who believe, the initial warning signs of H5N1 indicate a looming pandemic, I’d like to share the latest 13 studies posted in the past two months.
Reposted by Samuel 🏳️🌈
The preliminary sequence from the H5N1 human case in British Columbia has been posted and it is not good news. The virus potentially has a quasispecies at HA residue 226 (H3 numbering). This is bad news because we know that mutations at residue 226 can increase binding to human receptors. 1/
November 16, 2024 at 3:19 PM
The preliminary sequence from the H5N1 human case in British Columbia has been posted and it is not good news. The virus potentially has a quasispecies at HA residue 226 (H3 numbering). This is bad news because we know that mutations at residue 226 can increase binding to human receptors. 1/
Reposted by Samuel 🏳️🌈
Sequence from H5N1 case in BC uploaded recently to GISAID.
PB2 E627K (indicated by mixed E627X) mutation likely developed during infection, linked with mammalian adaptation, virulence in human Flu A.
NA N329 mutation: mild drug resistance.
HA sites E202, Q238 (host spec. shift) poorly resolved.
PB2 E627K (indicated by mixed E627X) mutation likely developed during infection, linked with mammalian adaptation, virulence in human Flu A.
NA N329 mutation: mild drug resistance.
HA sites E202, Q238 (host spec. shift) poorly resolved.
November 16, 2024 at 4:29 AM
Sequence from H5N1 case in BC uploaded recently to GISAID.
PB2 E627K (indicated by mixed E627X) mutation likely developed during infection, linked with mammalian adaptation, virulence in human Flu A.
NA N329 mutation: mild drug resistance.
HA sites E202, Q238 (host spec. shift) poorly resolved.
PB2 E627K (indicated by mixed E627X) mutation likely developed during infection, linked with mammalian adaptation, virulence in human Flu A.
NA N329 mutation: mild drug resistance.
HA sites E202, Q238 (host spec. shift) poorly resolved.