Antifibrotic therapy does not alter the natural history of #pulmonaryhypertension in #pulmonaryfibrosis and other #progressivePF #fibroticILD

bmcpulmmed.biomedcentral.com/articles/10....

Our dog is inspired in her sleep, dreaming and runnig while I listen to an old lecture from the late Prof. Brian Whipp
#ExercisePhysiology #ExerciseTesting
#ERSCongress 2007

On the Cover of @annalsats.bsky.social a picture of the pediatric department from which the senior author of this paper comes. The building was savagely attacked by an Iranian missile On June the 19th.

Dupilumab and #lymphoma risk among patients with #asthma: a population-based cohort study #BiologicsAsthma
Increased incidence of T and NK cell lymphoma and CTCL.
Clinical implications, yet to be determined.
publications.ersnet.org/content/erj/...

Rentosertib, A generative AI-discovered TNIK inhibitor for idiopathic #pulmonaryfibrosis: a randomized phase 2a trial
Interesting if consistently confirmed effective, seems to have a relatively small rate of GI side effects.
www.nature.com/articles/s41...

Remarkable: a treatment for progressive pulm. fibrosis #fibroticILD. #Nerandomilast a molecule with #antifibrotic and anti-inflammatory effect, slows down FVC deterioration. Additionally, a weak signal of benefit on secondary end points, seen beyond week 52 of therapy.
www.nejm.org/doi/full/10....

Nerandomilast slows FVC deterioration in IPF patients without/with background #antifibrotic therapy.
- No additional protection from IPF exacerbation
- Pirfenidone decreases plasma levels of Nerandomilast by 50% as opposed to nintedanib.
#pulmonaryfibrosis #ATS2025
www.nejm.org/doi/full/10....

How are the maximal limits of cardiac output determined?
A very interesting review and perspective.
physoc.onlinelibrary.wiley.com/doi/10.1113/...

Using GLI-2021 instead of ECSC for lung volumes (on plethysmography) could change the classification of observed PFT abnormality
www.resmedjournal.com/article/S095...

The prospects of using CT to detect #PulmonaryHypertension in #COPD, estimate it's severity and possible role in prescribing therapy.
#physiology
www.atsjournals.org/doi/full/10....

Efficacy and Safety of Admilparant, an LPA1 Antagonist, in #PulmonaryFibrosis: A Phase 2 Randomized Clinical Trial.

Admilprant 60mg twice daily for 26ww was effective in slowing FVC decline in IPF and PPF. Lower dose, 30mgx2/d was also effective in PPF.

PET-CT in ILD related to #scleroderma.
Quantitative 18F-FDG PET-CT can assess presence and extent of interstitial lung disease in early severe diffuse cutaneous systemic sclerosis.

arthritis-research.biomedcentral.com/articles/10....

Benralizumab remarkbly effective in treating #COPD exacerbations with eosinophilia (300 or more) compared with prednisone alone.

www.thelancet.com/journals/lan...

The oroginal Mr. Blue Sky, here for you 💙

This morning #EinKerem on my way to @HujiMed to teach #physiology
#RespiratoryPhysiology
#HebrewUnivMedSchool