So happy to be part of #ImmunoCambodia 2025! Magnificent setting, great Science. Master classes in the morning, art of grant writing in afternoon. Such a range of nationalities between students and instructors. What energy! Everyone is here to learn and to be inspired. #ImmunoEducation #IUISCourse

This #WorldMosquitoDay, @salehlabparis.bsky.social is proud to be part of the fight against mosquitoes and the viruses they transmit. 🦟🔬 #ResearchForHealth #ScienceInAction
Photo credit: our own Annabelle Henrion-Lacritick 👩‍🔬

Smiling as I attend the @amersocvirology.bsky.social meeting in Montreal - my first as Chair of Virology at @pasteur.fr. The hall is packed with 1,600+ brilliant minds. Great to reconnect with colleagues and to see first hand so much emerging talent.
#LoveVirology

Thrilled to receive @anrs-mie.bsky.social grant with @lambrechtslab.bsky.social & @retrogenomics.bsky.social! Making mosquitoes intolerant to arboviruses. Thanks @pasteur.fr, @inserm.fr & @cnrs.fr for support. Exciting times for #ARBORETRO project! Stay tunned.

For #IWD2025, the men from @salehlabparis.bsky.social share #ForAllWomenAndGirls:
We celebrate women’s strength, resilience, and achievements. Let’s honor those who fight every day, and stand united against discrimination and violence—equality is a right, and together we can build a fairer world.

Kicking off the new year in style! Activities included: finding the best "galette de rois" -yummy seasonal french pastry- of Paris (Mori Yoshida came in top again!), crowning of royalty, and of course a new beautiful group photo. #FoodieLife #TeamBuilding #ProudPI #LoveScience

What a pleasure to have hosted Shaeri Mukherjee for a minisabbatical in our lab! 🌟 Her brilliant science and insights have enriched us in so many ways. We’re already missing her! Thanks to @pasteur.fr and @UCSF for making this possible. 🧬💡#LoveScience #PILife #NewFriends

The best part of being a PI? Moments like this: running into Yasu Suzuki (not yet in BS) and @virotick.bsky.social, former Saleh Lab alumni, at #MBSJ2024 in Fukuoka. They're both PIs now, and I was so proud, I nearly burst out of my clothes! 🥹 #FullCircle #LoveScience #WomenInSTEM #LoveVirology

Hello! I will be presenting today at #MBSJ2024, in Fukuoka, at the symposium organized by -former Saleh lab member- Professor Yasu Suzuki and Prof Yasuko Orba. I will be discussing the work of @cassandrakoh.bsky.social on mosquito viromes. Come if you are around!

Hello Tokyo friends, I will be presenting our work on retrotransposons and antiviral immunity in insects tomorrow at 7 pm at @tokyouniversity.bsky.social. Please stop by to say hi if you are around!

Persistent viral infections are extremely common in laboratory fly stocks and our study demonstrates that they have profound physiological impacts. Check out our preprint to see even more! 10/11

Even more surprising? Ectopic activation of Sting in mock-infected flies recapitulated the homeostatic disruption seen in infected guts and shortened lifespan just as much as viral infection. 8/11

Yes it can! Viral infection did not induce intestinal stem cell proliferation in Relish or Sting mutants and the transcriptomes of mutant flies showed a clear absence of the mitogenic signaling that was seen in wild-type flies. The mutants also had prolonged lifespans! 7/11

How does viral infection induce intestinal stem cell proliferation? To find out we turned to RNA-seq 🧬. Drosophila A virus infection induced a strong NF-kB transcriptional response involving Relish and Sting. Could this response to infection modulate cellular turnover? 6/11

We wondered if increased cellular turnover is an antiviral mechanism or a tolerance strategy that is required to repair damage caused by viral infection. To our surprise, inhibiting intestinal stem cell proliferation actually prolonged the lifespan of infected flies!  5/11

We saw that the organization of the intestinal epithelium was disrupted in Drosophila A virus-infected flies. The guts of these flies also resembled those of aged flies - consistently high levels of intestinal stem cell proliferation and accumulation of Escargot + cells. 4/11

Find @salehlabparis.bsky.social members, Mauro and Eugenia, at the International Conference on Nucleic Acid Immunity, in Dresden. Thanks to the organizers for the talk and the poster slot to present our results. #NucleicAcidsRock #LoveImmunity #LoveScience