Change human physiology so that anyone who lies gets a bright red face for ten minutes - then we would know instead of having to guess what someone believes is true.

@richardakirk.bsky.social
@laurielipton.bsky.social
Am I allowed a little self-promotion??? You could look at the drawings on my profile
:-)

A period of research, (reading, experience, etc) to gather information. A period of synthesis to play with the information. Then working to express new findings. Then finally reporting in a suitable medium. Though it does depend on what type of art or academic research you are involved in.

What happened to the Presenilin Hypothesis? doi: 10.1073/pnas.0608332104. Was there ever follow up of the presenilin antagonist trial that was stopped early due to accelerated cognitive decline?

Thank you so much for posting this, you won't believe how well timed this is. :-)

I must be strange as a scientist. I appreciate that knowledge moves on and what was once thought to be good, in that perfect hindsight that we have, can be seen to be confounded. We must embrace corrections. It's a conversation that never ends, because everything is only ever an approximation.

Academic dementia researcher here: I'm still saying the same things I was saying 20 years ago. I feel like a failure and am weirdly looking forwards to the end of my funding so I can re-build myself.

There's a lovely review by Turner PR et al which is the first that describes APP as a molecular hub - Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol. 2003 May;70(1):1-32. doi: 10.1016/s0301-0082(03)00089-3.

It is almost as though people do not realise that there are an alternatives to the amyloid cascade and have been for over twenty years. The real question isn't about a lack of ideas but how one hypothesis was allowed to dominate. Why is it so hard for people to systematically survey the literature?

I based my whole career destroying approach on Turner et al 2003 see Hunter S, et al The APP Proteolytic System and Its Interactions with Dynamic Networks in Alzheimer's Disease. Methods Mol Biol. 2016;1303:71-99. doi: 10.1007/978-1-4939-2627-5_3. PMID: 26235060.

There's a lovely review by Turner PR et al which is the first that describes APP as a molecular hub - Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol. 2003 May;70(1):1-32. doi: 10.1016/s0301-0082(03)00089-3.

I've been raising my concerns for around 20 years. Issues relating to anti-abeta antibody cross-reactivities and confounding due to the complex proteolytic system of APP should have been addressed decades ago. www.j-alz.com/editors-blog...

I've been raising my concerns for around 20 years. Issues relating to anti-abeta antibody cross-reactivities and confounding due to the complex proteolytic system of APP should have been addressed decades ago. Who else finds it hard to publish critiques of the ACH? www.j-alz.com/editors-blog...

Gorgeous flow and detail! <3